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Published in: Current Infectious Disease Reports 4/2012

01-08-2012 | Cardiovascular Infections (DP Levine, Section Editor)

Q Fever Endocarditis: Does Serology Predict Outcome?

Author: Arístides de Alarcón

Published in: Current Infectious Disease Reports | Issue 4/2012

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Abstract

Q fever is an ubiquitous zoonosis caused by Coxiella burneti, an intracellular bacterium that can produce acute or chronic infections in humans. These forms are characterized by different evolution, serological profile and treatment that must be very long to achieve a cure in chronic forms. However, the serological profile for diagnosis and the real value of serology for predicting outcome are controversial, and management dilemmas for many patients with Q fever infection are continuously emerging. In this article, we describe in a comprehensive manner the different clinical presentations of the disease, making a critical overview of the evidence for serological predictions. We also take a broad view of new available diagnostic techniques and finally, we give recommendations for treatment.
Literature
1.
go back to reference Derrick EH. “Q” fever, a new fever entity: clinical features, diagnosis and laboratory investigations. Med J Aust. 1937;2:821–99. Derrick EH. “Q” fever, a new fever entity: clinical features, diagnosis and laboratory investigations. Med J Aust. 1937;2:821–99.
2.
go back to reference Burnet FM, Freeman M. Experimental studies on the virus of “Q” fever. Med J Aust. 1937;2:299–305. Burnet FM, Freeman M. Experimental studies on the virus of “Q” fever. Med J Aust. 1937;2:299–305.
3.
go back to reference Davis GE, Cox HR. A filter-passing infectious agent isolated from ticks.I. Isolation from Dermacentor andersonii, reactions with animals, and filtration experiments. Publ Health Rep. 1938;53:2259–76.CrossRef Davis GE, Cox HR. A filter-passing infectious agent isolated from ticks.I. Isolation from Dermacentor andersonii, reactions with animals, and filtration experiments. Publ Health Rep. 1938;53:2259–76.CrossRef
4.
go back to reference Dyer RE. Similarity of Australian “Q” fever and a disease caused by an infectious agent isolated from ticks in Montana. Publ Health Rep. 1939;54:1229–37.CrossRef Dyer RE. Similarity of Australian “Q” fever and a disease caused by an infectious agent isolated from ticks in Montana. Publ Health Rep. 1939;54:1229–37.CrossRef
5.
go back to reference Dijkstra F, Hoek W, Wijers N, et al. The 2007–2010 Q fever epidemic in the Netherlands: characteristics of notified acute Q fever patients and the association with dairy goat farming. FEMS Immunol Med Microbiol 2011, in press Dijkstra F, Hoek W, Wijers N, et al. The 2007–2010 Q fever epidemic in the Netherlands: characteristics of notified acute Q fever patients and the association with dairy goat farming. FEMS Immunol Med Microbiol 2011, in press
6.
go back to reference Raoult D, Marrie T, Mege J. Natural history and pathophysiology of Q fever. Lancet Infect Dis. 2005;5:219–26.PubMedCrossRef Raoult D, Marrie T, Mege J. Natural history and pathophysiology of Q fever. Lancet Infect Dis. 2005;5:219–26.PubMedCrossRef
7.
go back to reference McCaul TF, Williams JC. Development cycle of Coxiella burnetii: structure and morphogenesis of vegetative and sporogenic differentiations. J Bacteriol. 1981;147:1063–76.PubMed McCaul TF, Williams JC. Development cycle of Coxiella burnetii: structure and morphogenesis of vegetative and sporogenic differentiations. J Bacteriol. 1981;147:1063–76.PubMed
8.
go back to reference McCaul TF. The developmental cycle of Coxiella burnetii. In: Williams JC, Thompson HA, editors. Q fever: the biology of Coxiella burnetii. Boca Raton: CRC; 1991. p. 224–58. McCaul TF. The developmental cycle of Coxiella burnetii. In: Williams JC, Thompson HA, editors. Q fever: the biology of Coxiella burnetii. Boca Raton: CRC; 1991. p. 224–58.
9.
go back to reference Baca OG, Paretsky D. Q fever and Coxiella burnetii: a model for host-parasite interactions. Microbiol Rev. 1983;47:127–49.PubMed Baca OG, Paretsky D. Q fever and Coxiella burnetii: a model for host-parasite interactions. Microbiol Rev. 1983;47:127–49.PubMed
10.
go back to reference Gonder JC, Kishimoto RA, Kastello MD, et al. Cynomolgus monkey model for experimental Q fever infection. J Infect Dis. 1979;139:191–6.PubMedCrossRef Gonder JC, Kishimoto RA, Kastello MD, et al. Cynomolgus monkey model for experimental Q fever infection. J Infect Dis. 1979;139:191–6.PubMedCrossRef
11.
go back to reference • Angelakis E, Raoult D. Q fever. Vet Microbiol. 2010;140:297–309. These authors provide a good review of many aspects of this entity and its consequences in humans and animals.PubMedCrossRef • Angelakis E, Raoult D. Q fever. Vet Microbiol. 2010;140:297–309. These authors provide a good review of many aspects of this entity and its consequences in humans and animals.PubMedCrossRef
12.
go back to reference Johnson III JE, Kadu PJ. Laboratory acquired Q fever. A report of fifty cases. Am J Med. 1966;41:391–403.PubMedCrossRef Johnson III JE, Kadu PJ. Laboratory acquired Q fever. A report of fifty cases. Am J Med. 1966;41:391–403.PubMedCrossRef
13.
go back to reference Raoult D, Brouqui P, Marchou B, Gastaut JA. Acute and chronic Q fever in patients with cancer. Clin Infect Dis. 1992;14:127–30.PubMedCrossRef Raoult D, Brouqui P, Marchou B, Gastaut JA. Acute and chronic Q fever in patients with cancer. Clin Infect Dis. 1992;14:127–30.PubMedCrossRef
15.
go back to reference Boschini A, Di Perri G, Legnani D, et al. Consecutive epidemics of Q fever in a residential facility for drug abusers: impact on persons with human immunodeficiency virus infection. Clin Infect Dis. 1999;28:866–72.PubMedCrossRef Boschini A, Di Perri G, Legnani D, et al. Consecutive epidemics of Q fever in a residential facility for drug abusers: impact on persons with human immunodeficiency virus infection. Clin Infect Dis. 1999;28:866–72.PubMedCrossRef
16.
go back to reference Montes M, Cilla G, Marimon JM, et al. Coxiella burnetii infection in subjects with HIV infection and HIV infection in patients with Q fever. Scand J Infect Dis. 1995;27:344–6.PubMedCrossRef Montes M, Cilla G, Marimon JM, et al. Coxiella burnetii infection in subjects with HIV infection and HIV infection in patients with Q fever. Scand J Infect Dis. 1995;27:344–6.PubMedCrossRef
17.
go back to reference Sidwell RW, Thorpe BD, Gebhardt LP. Studies of latent Q fever infections. I. Efects of whole boy X-irradiation on latently infected guinea pigs, white mice and deer mice. Am J Hyg. 1964;79:113–24.PubMed Sidwell RW, Thorpe BD, Gebhardt LP. Studies of latent Q fever infections. I. Efects of whole boy X-irradiation on latently infected guinea pigs, white mice and deer mice. Am J Hyg. 1964;79:113–24.PubMed
18.
go back to reference Sidwell RW, Thorpe BD, Gebhardt LP. Studies of latent Q fever infections. II. Efects of multiple cortisone injection. Am J Hyg. 1964;79:320–7.PubMed Sidwell RW, Thorpe BD, Gebhardt LP. Studies of latent Q fever infections. II. Efects of multiple cortisone injection. Am J Hyg. 1964;79:320–7.PubMed
19.
go back to reference Samuel JE, Frazier ME, Mallavia LP. Correlation of plasmid type and disease caused by Coxiella burnetii. Infect Immun. 1985;49:775–9.PubMed Samuel JE, Frazier ME, Mallavia LP. Correlation of plasmid type and disease caused by Coxiella burnetii. Infect Immun. 1985;49:775–9.PubMed
20.
go back to reference Stein A, Raoult D. Lack of pathotype specific gene in human Coxiella burnetii isolates. Microb Pathog. 1993;15:177–85.PubMedCrossRef Stein A, Raoult D. Lack of pathotype specific gene in human Coxiella burnetii isolates. Microb Pathog. 1993;15:177–85.PubMedCrossRef
21.
go back to reference de Alarcón A, Villanueva JL, Viciana P, et al. Q fever: epidemiology, clinical features and prognosis. A study from 1983 to 1999 in the South of Spain. J Infect. 2003;47:110–6.PubMedCrossRef de Alarcón A, Villanueva JL, Viciana P, et al. Q fever: epidemiology, clinical features and prognosis. A study from 1983 to 1999 in the South of Spain. J Infect. 2003;47:110–6.PubMedCrossRef
22.
go back to reference Raoult D, Tissot-Dupont H, Foucault C, et al. Q fever 1985–1998. Clinical an epidemiologic features of 1,383 infections. Medicine. 2000;79:109–23.PubMedCrossRef Raoult D, Tissot-Dupont H, Foucault C, et al. Q fever 1985–1998. Clinical an epidemiologic features of 1,383 infections. Medicine. 2000;79:109–23.PubMedCrossRef
23.
go back to reference Spelman DW. Q fever: a stuy of 111 consecutive cases. Med J Austral. 1982;1:547–53.PubMed Spelman DW. Q fever: a stuy of 111 consecutive cases. Med J Austral. 1982;1:547–53.PubMed
24.
go back to reference Pebody RG, Wall PG, Ryan ML, Fairley C. Epidemiological features of Coxiella burnetii infection in England and Wales: 1984 to 1994. Commun Dis Rep. 1996;6:128–32. Pebody RG, Wall PG, Ryan ML, Fairley C. Epidemiological features of Coxiella burnetii infection in England and Wales: 1984 to 1994. Commun Dis Rep. 1996;6:128–32.
25.
26.
go back to reference Tselentis Y, Gikas A, Kofteridis D, et al. Q fever in the Greek Island of Crete: epidemiologic, clinical, and therapeutic data from 98 cases. Clin Infect Dis. 1995;20:1311–6.PubMedCrossRef Tselentis Y, Gikas A, Kofteridis D, et al. Q fever in the Greek Island of Crete: epidemiologic, clinical, and therapeutic data from 98 cases. Clin Infect Dis. 1995;20:1311–6.PubMedCrossRef
27.
go back to reference Ergas D, Keysari A, Edelstein V, Sthoeger ZM. Acute Q fever in Israel: Clinical and laboratory study of 100 hospitalized patients. Isr Med Assoc J. 2008;8(5):337–41. Ergas D, Keysari A, Edelstein V, Sthoeger ZM. Acute Q fever in Israel: Clinical and laboratory study of 100 hospitalized patients. Isr Med Assoc J. 2008;8(5):337–41.
28.
go back to reference Clark WH, Lennete EH, Railsback OC, Romer MS. Q fever in California. Arch Intern Med. 1951;58:155–61.CrossRef Clark WH, Lennete EH, Railsback OC, Romer MS. Q fever in California. Arch Intern Med. 1951;58:155–61.CrossRef
29.
go back to reference Vellend H, Salit IE, Spence L. Q fever-Ontario. Can Dis Wkly Rep. 1982;8:171. Vellend H, Salit IE, Spence L. Q fever-Ontario. Can Dis Wkly Rep. 1982;8:171.
30.
go back to reference Marrie TJ. Q fever, 1979–1987-Nova Scotia. Can Dis Wkly Rep. 1988;14:69–70.PubMed Marrie TJ. Q fever, 1979–1987-Nova Scotia. Can Dis Wkly Rep. 1988;14:69–70.PubMed
31.
go back to reference Montejo-Baranda M, Corral-Carranceja J, Aguirre-Errasti C. Q fever in the Basque country: 1981–1984. Rev Infect Dis. 1985;7:700–1.PubMedCrossRef Montejo-Baranda M, Corral-Carranceja J, Aguirre-Errasti C. Q fever in the Basque country: 1981–1984. Rev Infect Dis. 1985;7:700–1.PubMedCrossRef
32.
go back to reference Sobradillo V, Ansola P, Baranda F, Corral C. Q fever pneumonia: a review of 164 community acquired cases in the Basque country. Eur Respir J. 1989;2:263–6.PubMed Sobradillo V, Ansola P, Baranda F, Corral C. Q fever pneumonia: a review of 164 community acquired cases in the Basque country. Eur Respir J. 1989;2:263–6.PubMed
33.
go back to reference Javier Alvarez Gutiérrez F, del Castillo Otero D, García Fernández A, et al. Prospective study of 221 community acquired pneumonias followed up in an outpatient clinic. Etiology and clinical-radiological progression. Med Clin (Barc). 2001;116(5):161–6. Javier Alvarez Gutiérrez F, del Castillo Otero D, García Fernández A, et al. Prospective study of 221 community acquired pneumonias followed up in an outpatient clinic. Etiology and clinical-radiological progression. Med Clin (Barc). 2001;116(5):161–6.
34.
go back to reference Fournier PE, Etienne J, Harle JR, et al. Myocarditis, a rare but severe manifestation of Q fever: report of 8 cases and review of the literature. Clin Infect Dis. 2001;32:1440–7.PubMedCrossRef Fournier PE, Etienne J, Harle JR, et al. Myocarditis, a rare but severe manifestation of Q fever: report of 8 cases and review of the literature. Clin Infect Dis. 2001;32:1440–7.PubMedCrossRef
35.
go back to reference Bernit E, Puget J, Janbon F, et al. Neurological involvement in acute Q fever. A report of 29 cases and review of the literature. Arch Intern Med. 2002;162:693–700.PubMedCrossRef Bernit E, Puget J, Janbon F, et al. Neurological involvement in acute Q fever. A report of 29 cases and review of the literature. Arch Intern Med. 2002;162:693–700.PubMedCrossRef
36.
go back to reference • Fournier PE, Thuny F, Richet H, et al. Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases. Clin Infect Dis. 2010;51(2):131–40. The authors describe a diagnostic strategy that lead to a high percentage of aetiologic identification in blood culture-negative endocarditis. Coxiella burnetii was in this study one of the main causes.PubMedCrossRef • Fournier PE, Thuny F, Richet H, et al. Comprehensive diagnostic strategy for blood culture-negative endocarditis: a prospective study of 819 new cases. Clin Infect Dis. 2010;51(2):131–40. The authors describe a diagnostic strategy that lead to a high percentage of aetiologic identification in blood culture-negative endocarditis. Coxiella burnetii was in this study one of the main causes.PubMedCrossRef
37.
go back to reference Turk WP, Howitt G, Turnberg LA, et al. Chronic Q fever. Q J Med. 1976;45:193–217. Turk WP, Howitt G, Turnberg LA, et al. Chronic Q fever. Q J Med. 1976;45:193–217.
38.
go back to reference Brouqui P, Dupont HT, Drancourt M, et al. Chronic Q fever. Ninety-two cases from France, including 27 cases without endocarditis. Arch Intern Med. 1993;153:642–8.PubMedCrossRef Brouqui P, Dupont HT, Drancourt M, et al. Chronic Q fever. Ninety-two cases from France, including 27 cases without endocarditis. Arch Intern Med. 1993;153:642–8.PubMedCrossRef
39.
go back to reference Haldane EV, Marrie TJ, Faulkner RS, et al. Endocarditis due to Q fever in Nova Scottia: experience with five patients in 1981–1982. J Infect Dis. 1983;148:978–85.PubMedCrossRef Haldane EV, Marrie TJ, Faulkner RS, et al. Endocarditis due to Q fever in Nova Scottia: experience with five patients in 1981–1982. J Infect Dis. 1983;148:978–85.PubMedCrossRef
40.
go back to reference Wilson HG, Neilson GH, Galea EG, et al. Q fever endocarditis in Queensland. Circulation. 1976;53:680–4.PubMedCrossRef Wilson HG, Neilson GH, Galea EG, et al. Q fever endocarditis in Queensland. Circulation. 1976;53:680–4.PubMedCrossRef
41.
go back to reference Karakousis PC, Trucksis M, Dumler S. Chronic Q fever in the United States. J Clin Microbiol. 2006;44:2283–7.PubMedCrossRef Karakousis PC, Trucksis M, Dumler S. Chronic Q fever in the United States. J Clin Microbiol. 2006;44:2283–7.PubMedCrossRef
42.
43.
go back to reference Siegman-Igra Y, Kaufman O, Keysary A, et al. Q fever endocarditis in Israel and a worldwide review. Scand J Infect Dis. 1997;29:41–9.PubMedCrossRef Siegman-Igra Y, Kaufman O, Keysary A, et al. Q fever endocarditis in Israel and a worldwide review. Scand J Infect Dis. 1997;29:41–9.PubMedCrossRef
44.
go back to reference •• Mogollón MV, Anguita MP, Aguado JM, et al. Q fever endocarditis in Spain. Clinical characteristics and outcome. Enferm Infecc Microbiol Clin. 2011;29(2):109–16. This article reports a large cohort of patient with endocarditis. The utility of serology for predicting the outcome is largely questioned.PubMedCrossRef •• Mogollón MV, Anguita MP, Aguado JM, et al. Q fever endocarditis in Spain. Clinical characteristics and outcome. Enferm Infecc Microbiol Clin. 2011;29(2):109–16. This article reports a large cohort of patient with endocarditis. The utility of serology for predicting the outcome is largely questioned.PubMedCrossRef
45.
go back to reference Perez-Fontan M, Huarte E, Tellez A, et al. Glomerular nephropathy associated with chronic Q fever. Am J Kidney Dis. 1988;11(4):298–306.PubMed Perez-Fontan M, Huarte E, Tellez A, et al. Glomerular nephropathy associated with chronic Q fever. Am J Kidney Dis. 1988;11(4):298–306.PubMed
46.
go back to reference Leipidi H, Houpikian P, Liang Z, Raoult D. Cardiac valves in patients with Q fever endocarditis:microbiological, molecular and histologic studies. J Infect Dis. 2003;187:1097–106.CrossRef Leipidi H, Houpikian P, Liang Z, Raoult D. Cardiac valves in patients with Q fever endocarditis:microbiological, molecular and histologic studies. J Infect Dis. 2003;187:1097–106.CrossRef
47.
go back to reference •• Million M, Thuny F, Richet H, Raoult D. Long-term outcome of Q fever endocarditis: a 26-year personal survey. Lancet Infect Dis. 2010;10(8):527–35. The authors from the French National Reference Center for Rickettsial Diseases describe their experience with the largest serie of the world. Considerations about the optimun duration of treatment are provided with special consideration to serology.PubMedCrossRef •• Million M, Thuny F, Richet H, Raoult D. Long-term outcome of Q fever endocarditis: a 26-year personal survey. Lancet Infect Dis. 2010;10(8):527–35. The authors from the French National Reference Center for Rickettsial Diseases describe their experience with the largest serie of the world. Considerations about the optimun duration of treatment are provided with special consideration to serology.PubMedCrossRef
48.
go back to reference Botelho-Nevers E, Fournier PE, Richet H, et al. Coxiella burnetii infection of aortic aneurysms or vascular grafts: report 30new cases and evaluation of outcome. Eur Clin Microbiol Infect Dis. 2007;26(9):635–40.CrossRef Botelho-Nevers E, Fournier PE, Richet H, et al. Coxiella burnetii infection of aortic aneurysms or vascular grafts: report 30new cases and evaluation of outcome. Eur Clin Microbiol Infect Dis. 2007;26(9):635–40.CrossRef
49.
go back to reference Wegdam-Blans MCA, Vainas T, van Sambeek MR, et al. Vascular complications of Q-fever infections. Eur J Vasc Endovasc Surg. 2011;42:384–92.PubMedCrossRef Wegdam-Blans MCA, Vainas T, van Sambeek MR, et al. Vascular complications of Q-fever infections. Eur J Vasc Endovasc Surg. 2011;42:384–92.PubMedCrossRef
50.
go back to reference Nourse C, Allworth A, Jones A, et al. Three cases of Q fever osteomyelitis in children and a review of the literature. Clin Infect Dis. 2004;39:e61–6.PubMedCrossRef Nourse C, Allworth A, Jones A, et al. Three cases of Q fever osteomyelitis in children and a review of the literature. Clin Infect Dis. 2004;39:e61–6.PubMedCrossRef
51.
go back to reference Landais C, Fenollar F, Constantin A, et al. Q fever osteoarticular infection: four new cases and a review of the literature. Eur J Clin Microbiol Infect. 2007;26:341–7.CrossRef Landais C, Fenollar F, Constantin A, et al. Q fever osteoarticular infection: four new cases and a review of the literature. Eur J Clin Microbiol Infect. 2007;26:341–7.CrossRef
52.
go back to reference Delsol G, Pellegrini M, Familiades J, Auvergnat C. Bone marrow lesions in Q fever. Blood. 1978;52:637–8.PubMed Delsol G, Pellegrini M, Familiades J, Auvergnat C. Bone marrow lesions in Q fever. Blood. 1978;52:637–8.PubMed
53.
go back to reference Zoutman DE, Ralph ED, Frei JV. Hepatic fibrin-ring granulomas in granulomatous hepatitis: report of four cases and review of the literature. Acta Clin Belg. 2001;56(6):341–8. Zoutman DE, Ralph ED, Frei JV. Hepatic fibrin-ring granulomas in granulomatous hepatitis: report of four cases and review of the literature. Acta Clin Belg. 2001;56(6):341–8.
54.
go back to reference Stein A, Raoult D. Q fever during pregnancy: a public health problem in southern France. Clin Infect Dis. 1998;27(3):592–6.PubMedCrossRef Stein A, Raoult D. Q fever during pregnancy: a public health problem in southern France. Clin Infect Dis. 1998;27(3):592–6.PubMedCrossRef
55.
go back to reference • Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A. Q fever during pregnancy:a cause of poor fetal and maternal outcome. Ann N Y Acad Sci. 2009;116:79–8956. In this article the authors recommend to treat pregnant women with Q fever to avoid obstetric complications and maternal chronic Q fever.CrossRef • Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A. Q fever during pregnancy:a cause of poor fetal and maternal outcome. Ann N Y Acad Sci. 2009;116:79–8956. In this article the authors recommend to treat pregnant women with Q fever to avoid obstetric complications and maternal chronic Q fever.CrossRef
56.
go back to reference Rey D, Obadia Y, Tissot-Dupont H, Raoult D. Seroprevalence of antibodies to Coxiella burnetii among pregnant women in South Eastern France. Eur J Obstet Gynecol Reproduc Biol. 2009;93(2):57–61. Rey D, Obadia Y, Tissot-Dupont H, Raoult D. Seroprevalence of antibodies to Coxiella burnetii among pregnant women in South Eastern France. Eur J Obstet Gynecol Reproduc Biol. 2009;93(2):57–61.
57.
go back to reference Baud D, Peter O, Langel C, Regan L, Greub G. Seroprevalence of Coxiella burnetii and Brucella abortus among pregnant women. Clin Microbiol Infect. 2009;15(5):499–501.PubMedCrossRef Baud D, Peter O, Langel C, Regan L, Greub G. Seroprevalence of Coxiella burnetii and Brucella abortus among pregnant women. Clin Microbiol Infect. 2009;15(5):499–501.PubMedCrossRef
58.
go back to reference • van der Hoek W, Meekelenkamp JC, Leenders AC, et al. Antibodies against Coxiella burnetii and pregnancy outcome during the 2007–2008 Q fever outbreaks in The Netherlands. BMC Infect Dis. 2011;11:44. In this article, the authors conclude that there is no evidence of adverse pregnancy outcome among women who had antibodies to C. burnetii during early pregnancy.PubMedCrossRef • van der Hoek W, Meekelenkamp JC, Leenders AC, et al. Antibodies against Coxiella burnetii and pregnancy outcome during the 2007–2008 Q fever outbreaks in The Netherlands. BMC Infect Dis. 2011;11:44. In this article, the authors conclude that there is no evidence of adverse pregnancy outcome among women who had antibodies to C. burnetii during early pregnancy.PubMedCrossRef
59.
go back to reference Munster JM, Leenders AC, van der Hoek W, et al. Cost-effectiveness of a screening strategy for Q fever among pregnant women in risk areas: a clustered randomized controlled trial. BMC Womens Health. 2010;10:32.PubMedCrossRef Munster JM, Leenders AC, van der Hoek W, et al. Cost-effectiveness of a screening strategy for Q fever among pregnant women in risk areas: a clustered randomized controlled trial. BMC Womens Health. 2010;10:32.PubMedCrossRef
60.
go back to reference Houpikian P, Raoult D. Diagnostic methods, current best practices and guidelines for identification of difficult-to-culture pathogens in infective endocarditis. Infect Dis Clin North Am. 2002;16(2):377–92.PubMedCrossRef Houpikian P, Raoult D. Diagnostic methods, current best practices and guidelines for identification of difficult-to-culture pathogens in infective endocarditis. Infect Dis Clin North Am. 2002;16(2):377–92.PubMedCrossRef
61.
go back to reference •• Omsland A, Heinzen RA. Life on the outside: the rescue of Coxiella burnetii from its host cell. Annu Rev Microbiol. 2011;65:111–28. Excellent article in wich the long way to the isolation of Coxiella burnetii in an axenic medium is thoughtfully described.PubMedCrossRef •• Omsland A, Heinzen RA. Life on the outside: the rescue of Coxiella burnetii from its host cell. Annu Rev Microbiol. 2011;65:111–28. Excellent article in wich the long way to the isolation of Coxiella burnetii in an axenic medium is thoughtfully described.PubMedCrossRef
62.
go back to reference Peacock MG, Phillip RN, Williams JC, Faulkner R. Serological evaluation of Q fever in humans: enhanced phase I titers of Immunoglobulins G and A are diagnostic for Q fever endocarditis. Infect Immun. 1983;41:1089–98.PubMed Peacock MG, Phillip RN, Williams JC, Faulkner R. Serological evaluation of Q fever in humans: enhanced phase I titers of Immunoglobulins G and A are diagnostic for Q fever endocarditis. Infect Immun. 1983;41:1089–98.PubMed
63.
go back to reference Musso D, Raoult D. Serological cross-reactions between Coxiella burnetii and Legionella micdadei. Clin Diagn Lab Immunol. 1997;4(2):208–12.PubMed Musso D, Raoult D. Serological cross-reactions between Coxiella burnetii and Legionella micdadei. Clin Diagn Lab Immunol. 1997;4(2):208–12.PubMed
64.
go back to reference Schramek S, Kazár J, Sádecký E. Serological cross-reactions of lipid A components of lipopolysaccharides isolated from Chlamydia psittaci and Coxiella burnetii. Acta Virol. 1980;24(3):224.PubMed Schramek S, Kazár J, Sádecký E. Serological cross-reactions of lipid A components of lipopolysaccharides isolated from Chlamydia psittaci and Coxiella burnetii. Acta Virol. 1980;24(3):224.PubMed
65.
go back to reference La Scola B, Raoult D. Serological cross-reactions between Bartonella quintana, Bartonella henselae, and Coxiella burnetii. J Clin Microbiol. 1996;34(9):2270–4.PubMed La Scola B, Raoult D. Serological cross-reactions between Bartonella quintana, Bartonella henselae, and Coxiella burnetii. J Clin Microbiol. 1996;34(9):2270–4.PubMed
66.
go back to reference Raoult D, Tissot-Dupont H, Foucault C, et al. Q fever 1985–1998. Clinical and epidemiologic features of 1,383 infections. Medicine (Baltimore). 2000;79(2):109–23.CrossRef Raoult D, Tissot-Dupont H, Foucault C, et al. Q fever 1985–1998. Clinical and epidemiologic features of 1,383 infections. Medicine (Baltimore). 2000;79(2):109–23.CrossRef
67.
go back to reference Fournier PE, Casalta JP, Habib G, et al. Modification of the diagnostic criteria proposed by the Duke Endocarditis Service to permit improved diagnosis of Q fever endocarditis. Am J Med. 1996 Jun;100(6):629–33. Fournier PE, Casalta JP, Habib G, et al. Modification of the diagnostic criteria proposed by the Duke Endocarditis Service to permit improved diagnosis of Q fever endocarditis. Am J Med. 1996 Jun;100(6):629–33.
68.
go back to reference • van der Hoek W, Versteeg B, Meekelenkamp JC, Renders NH, Leenders AC, Weers-Pothoff I, Hermans MH, Zaaijer HL, Wever PC, Schneeberger PM. Follow-up of 686 patients with acute Q fever and detection of chronic infection. Clin Infect Dis. 2011;52(12):1431–6. In this study, a considerable number of patients with acute Q fever exhibited high antibodies titers to phase I antigens, but no evolution to chronic form was observed.PubMedCrossRef • van der Hoek W, Versteeg B, Meekelenkamp JC, Renders NH, Leenders AC, Weers-Pothoff I, Hermans MH, Zaaijer HL, Wever PC, Schneeberger PM. Follow-up of 686 patients with acute Q fever and detection of chronic infection. Clin Infect Dis. 2011;52(12):1431–6. In this study, a considerable number of patients with acute Q fever exhibited high antibodies titers to phase I antigens, but no evolution to chronic form was observed.PubMedCrossRef
69.
go back to reference • Hung MN, Lin LJ, Hou MY, et al. Serologic assessment of the risk of developing chronic Q fever in cohorts of acutely infected individuals. J Infect. 2011;62(1):39–44. High titers of phase I IgG and even progressive elevation of them ater an acute Q fever infection do not indicate or predict the development of chronic Q fever in this report.PubMedCrossRef • Hung MN, Lin LJ, Hou MY, et al. Serologic assessment of the risk of developing chronic Q fever in cohorts of acutely infected individuals. J Infect. 2011;62(1):39–44. High titers of phase I IgG and even progressive elevation of them ater an acute Q fever infection do not indicate or predict the development of chronic Q fever in this report.PubMedCrossRef
70.
go back to reference Frankel D, Richet H, Renvoisé A, Raoult D. Q fever in France, 1985–2009. Emerg Infect Dis. 2011;17(3):350–6.PubMed Frankel D, Richet H, Renvoisé A, Raoult D. Q fever in France, 1985–2009. Emerg Infect Dis. 2011;17(3):350–6.PubMed
71.
go back to reference Fenollar F, Fournier PE, Carrieri MP, et al. Risk factors and prevention of Q fever endocarditis. Clin Infect Dis. 2001;33:312–6.PubMedCrossRef Fenollar F, Fournier PE, Carrieri MP, et al. Risk factors and prevention of Q fever endocarditis. Clin Infect Dis. 2001;33:312–6.PubMedCrossRef
72.
go back to reference Fenollar F, Thuny F, Xeridat B, et al. Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. Clin Infect Dis. 2006;42(6):818–21.PubMedCrossRef Fenollar F, Thuny F, Xeridat B, et al. Endocarditis after acute Q fever in patients with previously undiagnosed valvulopathies. Clin Infect Dis. 2006;42(6):818–21.PubMedCrossRef
73.
go back to reference •• Healy B, van Woerden H, Raoult D, et al. Chronic Q fever: different serological results in three countries--results of a follow-up study 6 years after a point source outbreak. Clin Infect Dis. 2011;52(8):1013–9. In this study, concordance in immnunofluorescence result interpretation from 3 international reference laboratories was only 35 %. The interpretation o chronic serological profiles must be done with caution and always in accordance with the clinical picture.PubMedCrossRef •• Healy B, van Woerden H, Raoult D, et al. Chronic Q fever: different serological results in three countries--results of a follow-up study 6 years after a point source outbreak. Clin Infect Dis. 2011;52(8):1013–9. In this study, concordance in immnunofluorescence result interpretation from 3 international reference laboratories was only 35 %. The interpretation o chronic serological profiles must be done with caution and always in accordance with the clinical picture.PubMedCrossRef
74.
go back to reference Meekelenkamp JC, Schneeberger PM, Wever PC, Leenders AC. Comparison of ELISA and indirect immunofluorescent antibody assay detecting Coxiella burnetii IgM phase II for the diagnosis of acute Q fever. Eur J Clin Microbiol Infect Dis. 2011 Oct 14 (in press) Meekelenkamp JC, Schneeberger PM, Wever PC, Leenders AC. Comparison of ELISA and indirect immunofluorescent antibody assay detecting Coxiella burnetii IgM phase II for the diagnosis of acute Q fever. Eur J Clin Microbiol Infect Dis. 2011 Oct 14 (in press)
75.
go back to reference • Jager MM, Weers-Pothoff G, Hermans MH, et al. Evaluation of a diagnostic algorithm for acute Q fever in an outbreak setting. Clin Vaccine Immunol. 2011;18(6):963–8. In this article the authors reported their experience with serology (ELISA), immunofluorescece and PCR for acute Q fever diagnosis during the large outbreak in the Netherlands.A simple and effective algorithmis proposed.PubMedCrossRef • Jager MM, Weers-Pothoff G, Hermans MH, et al. Evaluation of a diagnostic algorithm for acute Q fever in an outbreak setting. Clin Vaccine Immunol. 2011;18(6):963–8. In this article the authors reported their experience with serology (ELISA), immunofluorescece and PCR for acute Q fever diagnosis during the large outbreak in the Netherlands.A simple and effective algorithmis proposed.PubMedCrossRef
76.
go back to reference Limonard GJ, Thijsen SF, Bossink AW, et al. Developing a new clinical tool for diagnosing chronic Q fever: the Coxiella ELISPOT. FEMS Immunol Med Microbiol. 2012;64(1):57–60.PubMedCrossRef Limonard GJ, Thijsen SF, Bossink AW, et al. Developing a new clinical tool for diagnosing chronic Q fever: the Coxiella ELISPOT. FEMS Immunol Med Microbiol. 2012;64(1):57–60.PubMedCrossRef
77.
go back to reference Schneeberger PM, Hermans MH, van Hannen EJ, et al. Real-time PCR with serum samples is indispensable for early diagnosis of acute Q fever. Clin Vaccine Immunol. 2010;17(2):286–90.PubMedCrossRef Schneeberger PM, Hermans MH, van Hannen EJ, et al. Real-time PCR with serum samples is indispensable for early diagnosis of acute Q fever. Clin Vaccine Immunol. 2010;17(2):286–90.PubMedCrossRef
78.
go back to reference •• Fenollar F, Fournier PE, Raoult D. Molecular detection of Coxiella burnetii in the sera of patients with Q fever endocarditis or vascular infection. J Clin Microbiol. 2004;42(11)):4919–24. In this study, the efficacy of PCR in blood samples for the diagnosis of chronic forms (mainly endocarditis) is analysed.PubMedCrossRef •• Fenollar F, Fournier PE, Raoult D. Molecular detection of Coxiella burnetii in the sera of patients with Q fever endocarditis or vascular infection. J Clin Microbiol. 2004;42(11)):4919–24. In this study, the efficacy of PCR in blood samples for the diagnosis of chronic forms (mainly endocarditis) is analysed.PubMedCrossRef
79.
go back to reference • Landais C, Fenollar F, Thuny F, Raoult D. From acute Q fever to endocarditis: serological follow-up strategy. Clin Infect Dis. 2007;44(10):1337–40. French authors propose in this study an algorithm based in serology and genomic amplification for preventing the development of chronic forms.PubMedCrossRef • Landais C, Fenollar F, Thuny F, Raoult D. From acute Q fever to endocarditis: serological follow-up strategy. Clin Infect Dis. 2007;44(10):1337–40. French authors propose in this study an algorithm based in serology and genomic amplification for preventing the development of chronic forms.PubMedCrossRef
81.
go back to reference Yeaman MR, Mitscher LA, Baca OG. In vitro susceptibility of Coxiella burnetii to antibiotics, including several quinolones. Antimicrob Agents Chemother. 1987;31(7):1079–84.PubMedCrossRef Yeaman MR, Mitscher LA, Baca OG. In vitro susceptibility of Coxiella burnetii to antibiotics, including several quinolones. Antimicrob Agents Chemother. 1987;31(7):1079–84.PubMedCrossRef
82.
go back to reference Ormsbee RA, Parker RA, Picens EG. The comparative effectiveness of aureomycin, terramycin, chloramphenicol erythromycin, and thiocymetin in suppressing experimental rickettsial infections in chick embryos. J Infect Dis. 1955;96(2):162–7.PubMedCrossRef Ormsbee RA, Parker RA, Picens EG. The comparative effectiveness of aureomycin, terramycin, chloramphenicol erythromycin, and thiocymetin in suppressing experimental rickettsial infections in chick embryos. J Infect Dis. 1955;96(2):162–7.PubMedCrossRef
84.
go back to reference Lai CH, Lin JN, Chang LL, Chen YH, Lin HH. Circulating cytokines and procalcitonin in acute Q fever granulomatous hepatitis with poor response to antibiotic and short-course steroid therapy: a case report. BMC Infect Dis. 2010;10:193.PubMedCrossRef Lai CH, Lin JN, Chang LL, Chen YH, Lin HH. Circulating cytokines and procalcitonin in acute Q fever granulomatous hepatitis with poor response to antibiotic and short-course steroid therapy: a case report. BMC Infect Dis. 2010;10:193.PubMedCrossRef
85.
go back to reference Crespo M, Sopeña B, Bordón J, et al. Steroids treatment of granulomatous hepatitis complicating Coxiella burnetii acute infection. Infection. 1999;27(2):132–3.PubMedCrossRef Crespo M, Sopeña B, Bordón J, et al. Steroids treatment of granulomatous hepatitis complicating Coxiella burnetii acute infection. Infection. 1999;27(2):132–3.PubMedCrossRef
86.
go back to reference Garcia-Alfranca F, Clemente-Rodriguez C, Pigrau-Serrallach C, et al. Q fever associated with persistent fever: an immunologic disorder? Clin Infect Dis. 1994;18(1):122–3.PubMedCrossRef Garcia-Alfranca F, Clemente-Rodriguez C, Pigrau-Serrallach C, et al. Q fever associated with persistent fever: an immunologic disorder? Clin Infect Dis. 1994;18(1):122–3.PubMedCrossRef
87.
go back to reference Stein A, Raoult D. Q fever endocarditis. Eur Heart J. 1995;16:19–23.PubMed Stein A, Raoult D. Q fever endocarditis. Eur Heart J. 1995;16:19–23.PubMed
88.
go back to reference Levy PY, Drancourt M, Etienne J. Comparison of different antibiotic regimens for therapy of 32 cases of Q fever endocarditis. Antimicrob Agents Chemother. 1991;35(3):533–7.PubMedCrossRef Levy PY, Drancourt M, Etienne J. Comparison of different antibiotic regimens for therapy of 32 cases of Q fever endocarditis. Antimicrob Agents Chemother. 1991;35(3):533–7.PubMedCrossRef
89.
go back to reference Maurin M, Benoliel AM, Bongrand P, Raoult D. Phagolysosomes of Coxiella burnetii-infected cells lines maintains an acidic pH during persistant infection. Infect Immun. 1992;60:5013–6.PubMed Maurin M, Benoliel AM, Bongrand P, Raoult D. Phagolysosomes of Coxiella burnetii-infected cells lines maintains an acidic pH during persistant infection. Infect Immun. 1992;60:5013–6.PubMed
90.
go back to reference Maurin M, Benoliel AM, Bongrand P, Raoult D. Phagolysosomal alkalinization and the bactericidal effect of antibiotics: the Coxiella burnetii paradigm. J Infect Dis. 1992;33:428–31. Maurin M, Benoliel AM, Bongrand P, Raoult D. Phagolysosomal alkalinization and the bactericidal effect of antibiotics: the Coxiella burnetii paradigm. J Infect Dis. 1992;33:428–31.
91.
go back to reference Raoult D, Houpikian P, Tissot-Dupont H, Riss JM, Arditi-Djiane J, Brouqui P. Treatment of Q fever endocarditis. Comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine. Arch Intern Med. 1999;159:167–73.PubMedCrossRef Raoult D, Houpikian P, Tissot-Dupont H, Riss JM, Arditi-Djiane J, Brouqui P. Treatment of Q fever endocarditis. Comparison of 2 regimens containing doxycycline and ofloxacin or hydroxychloroquine. Arch Intern Med. 1999;159:167–73.PubMedCrossRef
92.
go back to reference Abril V, Ortega E, Segarra P, Fraile T. Late recurrence of endocarditis caused by Coxiella burnetii folowing prosthetic valve substitution and prolonged antibiotic treatment. Enferm Infecc Microbiol Clin. 1999;17:478–9. Abril V, Ortega E, Segarra P, Fraile T. Late recurrence of endocarditis caused by Coxiella burnetii folowing prosthetic valve substitution and prolonged antibiotic treatment. Enferm Infecc Microbiol Clin. 1999;17:478–9.
93.
go back to reference Morguet AJ, Jansen A, Raoult D, Schneider T. Late relapse of Q fever endocarditis. Clin Res Cardiol. 2007;96:519–21.PubMedCrossRef Morguet AJ, Jansen A, Raoult D, Schneider T. Late relapse of Q fever endocarditis. Clin Res Cardiol. 2007;96:519–21.PubMedCrossRef
94.
go back to reference Habib G, Hoen B, Tornos P, et al. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. Eur Heart J. 2009;30(19):2369–413.PubMedCrossRef Habib G, Hoen B, Tornos P, et al. Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): the Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) and the International Society of Chemotherapy (ISC) for Infection and Cancer. Eur Heart J. 2009;30(19):2369–413.PubMedCrossRef
95.
go back to reference Rolain JM, Mallet MN, Raoult D. Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis. J Infect Dis. 2003;188:1322–5.PubMedCrossRef Rolain JM, Mallet MN, Raoult D. Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis. J Infect Dis. 2003;188:1322–5.PubMedCrossRef
96.
go back to reference Lecaillet A, Mallet MN, Raoult D, Rolain JM. Therapeutic impact of the correlation of doxycycline serum concentrations and the decline of phase I antibodies in Q fever endocarditis. J Antimicrob Chemother. 2009;63(4):771–4.PubMedCrossRef Lecaillet A, Mallet MN, Raoult D, Rolain JM. Therapeutic impact of the correlation of doxycycline serum concentrations and the decline of phase I antibodies in Q fever endocarditis. J Antimicrob Chemother. 2009;63(4):771–4.PubMedCrossRef
97.
go back to reference Sánchez-Recalde A, Maté I, López E, et al. Coxiella burnetii endocarditis: long term follow up of 20 patients. Rev Esp Cardiol. 2000;53:940–6.PubMedCrossRef Sánchez-Recalde A, Maté I, López E, et al. Coxiella burnetii endocarditis: long term follow up of 20 patients. Rev Esp Cardiol. 2000;53:940–6.PubMedCrossRef
98.
go back to reference Houpikian P, Habib G, Mesana T, Raoult D. Changing clinical presentation of Q fever endocarditis. Clin Infect Dis. 2002;34:e28–31.PubMedCrossRef Houpikian P, Habib G, Mesana T, Raoult D. Changing clinical presentation of Q fever endocarditis. Clin Infect Dis. 2002;34:e28–31.PubMedCrossRef
Metadata
Title
Q Fever Endocarditis: Does Serology Predict Outcome?
Author
Arístides de Alarcón
Publication date
01-08-2012
Publisher
Current Science Inc.
Published in
Current Infectious Disease Reports / Issue 4/2012
Print ISSN: 1523-3847
Electronic ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-012-0264-6

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