Skip to main content
Top
Published in: Current Infectious Disease Reports 2/2010

01-03-2010

The Role of Adenovirus in Respiratory Tract Infections

Authors: Anjali N. Kunz, Martin Ottolini

Published in: Current Infectious Disease Reports | Issue 2/2010

Login to get access

Abstract

Adenovirus plays a significant role in respiratory tract disease in pediatric and adult patients. It has been linked to outbreaks and epidemics in various patient populations, resulting in considerable morbidity and mortality. In this article, we discuss the epidemiology, pathogenesis, respiratory tract illnesses and complications, and roles of potential treatment options. The role of the past oral adenovirus vaccine and the military implications of its withdrawal from routine use in military recruits is discussed as well.
Literature
2.
go back to reference Mandell GL, Bennett JE, Dolin R: Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, edn 7. Philadelphia: Elsevier; 2009. Mandell GL, Bennett JE, Dolin R: Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, edn 7. Philadelphia: Elsevier; 2009.
3.
go back to reference Rowe WP, Huebner RJ, Gillmore LK, et al.: Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med 1953, 84:570–573.PubMed Rowe WP, Huebner RJ, Gillmore LK, et al.: Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med 1953, 84:570–573.PubMed
4.
go back to reference Brandt CD, Kim HW, Vargosko AJ, et al.: Infections in 18,000 infants and children in a controlled study of respiratory tract disease. I. Adenovirus pathogenicity in relation to serologic type and illness syndrome. Am J Epidemol 1969, 90:484–500. Brandt CD, Kim HW, Vargosko AJ, et al.: Infections in 18,000 infants and children in a controlled study of respiratory tract disease. I. Adenovirus pathogenicity in relation to serologic type and illness syndrome. Am J Epidemol 1969, 90:484–500.
5.
go back to reference Hale, GA, Heslop HE, Krance RA, et al.: Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant 1999, 23:277–282. Hale, GA, Heslop HE, Krance RA, et al.: Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transplant 1999, 23:277–282.
6.
go back to reference Kolavic-Gray SA, Binn LN, Sanchez JL, et al.: Large epidemic of adenovirus type 14 infection among military trainees: epidemiological, clinical and laboratory studies. Clin Infect Dis 2002, 35:808–818.CrossRefPubMed Kolavic-Gray SA, Binn LN, Sanchez JL, et al.: Large epidemic of adenovirus type 14 infection among military trainees: epidemiological, clinical and laboratory studies. Clin Infect Dis 2002, 35:808–818.CrossRefPubMed
7.
go back to reference Van Der Veen J, Dijkman JH: Associations of type 21 Adenovirus with acute respiratory illness in military recruits. Am J Hyg 1962, 76:149–159. Van Der Veen J, Dijkman JH: Associations of type 21 Adenovirus with acute respiratory illness in military recruits. Am J Hyg 1962, 76:149–159.
8.
go back to reference Dudding BA, Wagner SC, Zeller JA, et al.: Fatal pneumonia associated with adenovirus type 7 in three military trainees. N Engl J Med 1972, 286:1289–1292.PubMedCrossRef Dudding BA, Wagner SC, Zeller JA, et al.: Fatal pneumonia associated with adenovirus type 7 in three military trainees. N Engl J Med 1972, 286:1289–1292.PubMedCrossRef
9.
go back to reference Klinger JR, Sanchez MP, Curtin LA, et al.: Multiple cases of life-threatening adenovirus pneumonia in a mental health care center. Am J Respir Crit Care Med 1998, 157:645–549.PubMed Klinger JR, Sanchez MP, Curtin LA, et al.: Multiple cases of life-threatening adenovirus pneumonia in a mental health care center. Am J Respir Crit Care Med 1998, 157:645–549.PubMed
10.
go back to reference • Hakim FA, Tleyjeh IM: Severe adenovirus pneumonia in immunocompetent adults: a case report and review of the literature. Eur J Clin Microbiol Infect Dis 2008, 27:153–158. This article describes severe adenovirus pneumonia with ARDS in immunocompetent adults, which is an unusual clinical presentation.CrossRefPubMed • Hakim FA, Tleyjeh IM: Severe adenovirus pneumonia in immunocompetent adults: a case report and review of the literature. Eur J Clin Microbiol Infect Dis 2008, 27:153–158. This article describes severe adenovirus pneumonia with ARDS in immunocompetent adults, which is an unusual clinical presentation.CrossRefPubMed
11.
go back to reference Osamura T, Mizuta R, Yoshika H, et al.: Isolation of adenovirus type 11 from the brain of a neonate with pneumonia and encephalitis. Eur J Pediatr 1993, 152:496–499.CrossRefPubMed Osamura T, Mizuta R, Yoshika H, et al.: Isolation of adenovirus type 11 from the brain of a neonate with pneumonia and encephalitis. Eur J Pediatr 1993, 152:496–499.CrossRefPubMed
12.
go back to reference Pinto A, Beck R, Jadavji T: Fatal neonatal pneumonia caused by adenovirus type 35. Report of one case and review of the literature. Arch Pathol Lab Med 1992, 116:95–99.PubMed Pinto A, Beck R, Jadavji T: Fatal neonatal pneumonia caused by adenovirus type 35. Report of one case and review of the literature. Arch Pathol Lab Med 1992, 116:95–99.PubMed
13.
go back to reference Wigger HJ, Blanc WA: Fatal hepatic and bronchial necrosis in adenovirus infection with thymic dysplasia. N Engl J Med 1964, 275:870–874.CrossRef Wigger HJ, Blanc WA: Fatal hepatic and bronchial necrosis in adenovirus infection with thymic dysplasia. N Engl J Med 1964, 275:870–874.CrossRef
14.
go back to reference Leen AM, Rooney CM: Adenovirus as an emerging pathogen in immunocompromised patients. Br J Haematol 2005, 128:135–144.CrossRefPubMed Leen AM, Rooney CM: Adenovirus as an emerging pathogen in immunocompromised patients. Br J Haematol 2005, 128:135–144.CrossRefPubMed
15.
go back to reference Kojaoghlanian T, Flomenberg P, Horwitz MS: The impact of adenovirus infection on the immunocompromised host. Rev Med Virol 2003, 13:155–171.CrossRefPubMed Kojaoghlanian T, Flomenberg P, Horwitz MS: The impact of adenovirus infection on the immunocompromised host. Rev Med Virol 2003, 13:155–171.CrossRefPubMed
16.
go back to reference Krilov LR, Rubin LG, Frogel M, et al.: Disseminated adenovirus infection with hepatic necrosis in patients with HIV and other immunodeficiency states. Rev Infect Dis 1990, 12:303–307.PubMed Krilov LR, Rubin LG, Frogel M, et al.: Disseminated adenovirus infection with hepatic necrosis in patients with HIV and other immunodeficiency states. Rev Infect Dis 1990, 12:303–307.PubMed
17.
go back to reference Dingle JH, Langmuir AD: Epidemiology of acute respiratory disease in military recruits. Am Rev Respir Dis 1968, 97(Suppl):1–65. Dingle JH, Langmuir AD: Epidemiology of acute respiratory disease in military recruits. Am Rev Respir Dis 1968, 97(Suppl):1–65.
18.
go back to reference Top FH, Dudding BA, Russell PK, et al.: Control of respiratory disease in recruits with types 4 and 7 adenovirus vaccines. Am J Epidemiol 1971, 94:142–146.PubMed Top FH, Dudding BA, Russell PK, et al.: Control of respiratory disease in recruits with types 4 and 7 adenovirus vaccines. Am J Epidemiol 1971, 94:142–146.PubMed
19.
go back to reference • Metzgar D, Osuna M, Kajon AE, et al.: Abrupt emergence of diverse species B adenoviruses at US military recruit training centers. J Infect Dis 2007, 196:1465–1473. This important article details the alarming rise in respiratory tract infections with adenovirus serotypes 4, 7, 14, and 21 in military recruits across the United States.CrossRefPubMed • Metzgar D, Osuna M, Kajon AE, et al.: Abrupt emergence of diverse species B adenoviruses at US military recruit training centers. J Infect Dis 2007, 196:1465–1473. This important article details the alarming rise in respiratory tract infections with adenovirus serotypes 4, 7, 14, and 21 in military recruits across the United States.CrossRefPubMed
20.
go back to reference • Tate JE, Bunning ML, Lott L, et al.: Outbreak of severe respiratory disease associated with emergent human adenovirus serotype 14 at a US air force training facility in 2007. J Infect Dis May 2009, 199:1419–1426. This article focuses on the severity of adenovirus 14 in healthy military recruits, and its importance as an emerging pathogen in this population.CrossRef • Tate JE, Bunning ML, Lott L, et al.: Outbreak of severe respiratory disease associated with emergent human adenovirus serotype 14 at a US air force training facility in 2007. J Infect Dis May 2009, 199:1419–1426. This article focuses on the severity of adenovirus 14 in healthy military recruits, and its importance as an emerging pathogen in this population.CrossRef
21.
go back to reference Laham FR, Jewell AM, Schoonover AL, et al.: The search for adenovirus 14 in children in Houston, Texas. Pediatr Infect Dis J 2008, 27:653–654.CrossRefPubMed Laham FR, Jewell AM, Schoonover AL, et al.: The search for adenovirus 14 in children in Houston, Texas. Pediatr Infect Dis J 2008, 27:653–654.CrossRefPubMed
22.
go back to reference •• Lewis, PF, Schmidt MA, Lu X, et al.: A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14. J Infect Dis May 2009, 199:1427–1434. This article describes the clinical presentation and impact of a community outbreak of adenovirus 14.CrossRef •• Lewis, PF, Schmidt MA, Lu X, et al.: A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14. J Infect Dis May 2009, 199:1427–1434. This article describes the clinical presentation and impact of a community outbreak of adenovirus 14.CrossRef
23.
go back to reference Shields A, Hackman R, Fife K, et al.: Adenovirus infection in patients undergoing bone-marrow transplantation. N Engl J Med 1985, 312:529–533.PubMed Shields A, Hackman R, Fife K, et al.: Adenovirus infection in patients undergoing bone-marrow transplantation. N Engl J Med 1985, 312:529–533.PubMed
24.
go back to reference Flomenberg P, Babbit J, Drobyski W, et al.: Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis 1994, 169:775–781.PubMed Flomenberg P, Babbit J, Drobyski W, et al.: Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis 1994, 169:775–781.PubMed
25.
go back to reference Aronson B, Aronson S, Sobel G, et al.: Pharyngoconjunctival fevers; report of an epidemic outbreak. AMA J Dis Child 1956, 92:596–612.PubMed Aronson B, Aronson S, Sobel G, et al.: Pharyngoconjunctival fevers; report of an epidemic outbreak. AMA J Dis Child 1956, 92:596–612.PubMed
26.
go back to reference Bell JA: Clinical manifestation of pharyngoconjunctival fever. Am J Opthalmol 1957, 43:11–14. Bell JA: Clinical manifestation of pharyngoconjunctival fever. Am J Opthalmol 1957, 43:11–14.
27.
go back to reference Chaberny IE, Schnitzler P, Geiss HK, Wendt C: An outbreak of epidemic keratoconjunctivitis in a pediatric unit due to adenovirus type 8. Infect Control Hosp Epidemiol 2003, 24:514–519.CrossRefPubMed Chaberny IE, Schnitzler P, Geiss HK, Wendt C: An outbreak of epidemic keratoconjunctivitis in a pediatric unit due to adenovirus type 8. Infect Control Hosp Epidemiol 2003, 24:514–519.CrossRefPubMed
28.
go back to reference Buffington J, Chapman LE, Stobierski MG, et al.: Epidemic keratoconjunctivitis in a chronic care facility: risk factors and measures for control. J Am Geriatr Soc 1993, 41:1177–1181.PubMed Buffington J, Chapman LE, Stobierski MG, et al.: Epidemic keratoconjunctivitis in a chronic care facility: risk factors and measures for control. J Am Geriatr Soc 1993, 41:1177–1181.PubMed
29.
go back to reference Usui N, Ookoshi H, Mori H, et al.: Clinical features of epidemic keratoconjunctivitis in 41 patients. Nippon Ganka Gakkai Zasshi 2001, 105:183–188.PubMed Usui N, Ookoshi H, Mori H, et al.: Clinical features of epidemic keratoconjunctivitis in 41 patients. Nippon Ganka Gakkai Zasshi 2001, 105:183–188.PubMed
30.
go back to reference Engelmann I, Madisch I, Pommer H, Heim A: An outbreak of epidemic keratoconjuctivitis caused by a new intermediate adenovirus 22/H8 identified by molecular typing. Clin Infect Dis 2006, 43:e64–e66.CrossRefPubMed Engelmann I, Madisch I, Pommer H, Heim A: An outbreak of epidemic keratoconjuctivitis caused by a new intermediate adenovirus 22/H8 identified by molecular typing. Clin Infect Dis 2006, 43:e64–e66.CrossRefPubMed
31.
go back to reference Murrah WF: Epidemic keratoconjunctivitis. Ann Ophthalmol 1988, 20:36–38.PubMed Murrah WF: Epidemic keratoconjunctivitis. Ann Ophthalmol 1988, 20:36–38.PubMed
32.
go back to reference Damen M, Minnaar R, Glasius P, et al.: Real-time PCR with an internal control for detection of all known human adenovirus serotypes. J Clin Microbiol 2008, 46:3997–4003.CrossRefPubMed Damen M, Minnaar R, Glasius P, et al.: Real-time PCR with an internal control for detection of all known human adenovirus serotypes. J Clin Microbiol 2008, 46:3997–4003.CrossRefPubMed
33.
go back to reference • Wong S, Pabbaraju K, Pang XL, et al.: Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real-time PCR assay. J Med Virol 2008, 80:856–865. This article shows the utility and sensitivity of real-time PCR in detecting most clinically relevant adenovirus serotypes.CrossRefPubMed • Wong S, Pabbaraju K, Pang XL, et al.: Detection of a broad range of human adenoviruses in respiratory tract samples using a sensitive multiplex real-time PCR assay. J Med Virol 2008, 80:856–865. This article shows the utility and sensitivity of real-time PCR in detecting most clinically relevant adenovirus serotypes.CrossRefPubMed
34.
go back to reference Metzgar D, Skochko G, Gibbins C, et al.: Evaluation and validation of a real-time PCR assay for detection and quantitation of human adenovirus 14 from clinical samples. PLoS One 2009, 4:e7081.CrossRefPubMed Metzgar D, Skochko G, Gibbins C, et al.: Evaluation and validation of a real-time PCR assay for detection and quantitation of human adenovirus 14 from clinical samples. PLoS One 2009, 4:e7081.CrossRefPubMed
35.
go back to reference Bruno B, Gooley T, Hackman RC, et al.: Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biol Blood Marrow Transplant 2003, 9:341–352.CrossRefPubMed Bruno B, Gooley T, Hackman RC, et al.: Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biol Blood Marrow Transplant 2003, 9:341–352.CrossRefPubMed
36.
go back to reference Legrand F, Berrebi D, Houhou N, et al: Early diagnosis of adenovirus infection and treatment with cidofovir after bone marrow transplantation in children. Bone Marrow Transplant 2001, 27:621–626.CrossRefPubMed Legrand F, Berrebi D, Houhou N, et al: Early diagnosis of adenovirus infection and treatment with cidofovir after bone marrow transplantation in children. Bone Marrow Transplant 2001, 27:621–626.CrossRefPubMed
37.
go back to reference Saquib R, Melton LB, Chandrakantan A, et al.: Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin. Transpl Infect Dis 2009 (Epub ahead of print). Saquib R, Melton LB, Chandrakantan A, et al.: Disseminated adenovirus infection in renal transplant recipients: the role of cidofovir and intravenous immunoglobulin. Transpl Infect Dis 2009 (Epub ahead of print).
38.
go back to reference Lessler J, Reich NG, Brookmeyer R, et al.: Incubation periods of acute respiratory viral infections: a systemic review. Lancet Infect Dis 2009, 9:291–300.CrossRefPubMed Lessler J, Reich NG, Brookmeyer R, et al.: Incubation periods of acute respiratory viral infections: a systemic review. Lancet Infect Dis 2009, 9:291–300.CrossRefPubMed
39.
go back to reference Russell KL, Hawksworth AW, Ryan MAK, et al.: Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004. Vaccine 2006, 24:2835–2842.CrossRefPubMed Russell KL, Hawksworth AW, Ryan MAK, et al.: Vaccine-preventable adenoviral respiratory illness in US military recruits, 1999–2004. Vaccine 2006, 24:2835–2842.CrossRefPubMed
40.
go back to reference Hilleman MR: Efficacy of and indications for use of adenovirus vaccine. Am J Public Health Nations Health 1958, 48:153–158.PubMed Hilleman MR: Efficacy of and indications for use of adenovirus vaccine. Am J Public Health Nations Health 1958, 48:153–158.PubMed
41.
go back to reference Kolavic-Gray SA, Binn LN, Sanchez JL, et al: Large epidemic of adenovirus type 4 infection among military trainees: epidemiological, clinical and laboratory studies. Clin Infect Dis 2002, 35:808–818.CrossRefPubMed Kolavic-Gray SA, Binn LN, Sanchez JL, et al: Large epidemic of adenovirus type 4 infection among military trainees: epidemiological, clinical and laboratory studies. Clin Infect Dis 2002, 35:808–818.CrossRefPubMed
42.
go back to reference • Lyons A, Longfield J, Kuschner R, et al.: A double-blinded, placebo-controlled study of the safety and immunogenicity of live, oral type 4 and type 7 adenovirus vaccines in adults. Vaccine 2008, 26:2890–2898. This article discusses the results of the new live, oral adenovirus vaccines during their phase 1 clinical trials.CrossRefPubMed • Lyons A, Longfield J, Kuschner R, et al.: A double-blinded, placebo-controlled study of the safety and immunogenicity of live, oral type 4 and type 7 adenovirus vaccines in adults. Vaccine 2008, 26:2890–2898. This article discusses the results of the new live, oral adenovirus vaccines during their phase 1 clinical trials.CrossRefPubMed
Metadata
Title
The Role of Adenovirus in Respiratory Tract Infections
Authors
Anjali N. Kunz
Martin Ottolini
Publication date
01-03-2010
Publisher
Current Science Inc.
Published in
Current Infectious Disease Reports / Issue 2/2010
Print ISSN: 1523-3847
Electronic ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-010-0084-5

Other articles of this Issue 2/2010

Current Infectious Disease Reports 2/2010 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine