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01-02-2011

Genetics of Hypertension and Cardiovascular Disease and Their Interconnected Pathways: Lessons from Large Studies

Authors: Aldi T. Kraja, Steven C. Hunt, D. C. Rao, Victor G. Dávila-Román, Donna K. Arnett, Michael A. Province

Published in: Current Hypertension Reports | Issue 1/2011

Abstract

Blood pressure (BP), hypertension (HT) and cardiovascular disease (CVD) are common complex phenotypes, which are affected by multiple genetic and environmental factors. This article describes recent genome-wide association studies (GWAS) that have reported causative variants for BP/HT and CVD/heart traits and analyzes the overlapping associated gene polymorphisms. It also examines potential replication of findings from the HyperGEN data on African Americans and whites. Several genes involved in BP/HT regulation also appear to be involved in CVD. A better picture is emerging, with overlapping hot-spot regions and with interconnected pathways between BP/HT and CVD. A systemic approach to full understanding of BP/HT and CVD development and their progression to disease may lead to the identification of gene targets and pathways for the development of novel therapeutic interventions.

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Title: Genetics of Hypertension and Cardiovascular Disease and Their Interconnected Pathways: Lessons from Large Studies
Authors: Aldi T. Kraja
Steven C. Hunt
D. C. Rao
Victor G. Dávila-Román
Donna K. Arnett
Michael A. Province
Publication date: 01-02-2011
Publisher: Current Science Inc.
Published in: Current Hypertension Reports / Issue 1/2011
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-010-0174-7

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