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Current Hematologic Malignancy Reports
Published in: Current Hematologic Malignancy Reports 3/2017

01-06-2017 | B-cell NHL, T-cell NHL, and Hodgkin Lymphoma (D Persky, Section Editor)

A Review of Autologous Stem Cell Transplantation in Lymphoma

Authors: Umar Zahid, Faisal Akbar, Akshay Amaraneni, Muhammad Husnain, Onyee Chan, Irbaz Bin Riaz, Ali McBride, Ahmad Iftikhar, Faiz Anwer

Published in: Current Hematologic Malignancy Reports | Issue 3/2017

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Abstract

Purpose of Review

Chemotherapy remains the first-line therapy for aggressive lymphomas. However, 20–30% of patients with non-Hodgkin lymphoma (NHL) and 15% with Hodgkin lymphoma (HL) recur after initial therapy. We want to explore the role of high-dose chemotherapy (HDT) and autologous stem cell transplant (ASCT) for these patients.

Recent Findings

There is some utility of upfront consolidation for-high risk/high-grade B-cell lymphoma, mantle cell lymphoma, and T-cell lymphoma, but there is no role of similar intervention for HL. New conditioning regimens are being investigated which have demonstrated an improved safety profile without compromising the myeloablative efficiency for relapsed or refractory HL.

Summary

Salvage chemotherapy followed by HDT and rescue autologous stem cell transplant remains the standard of care for relapsed/refractory lymphoma. The role of novel agents to improve disease-related parameters remains to be elucidated in frontline induction, disease salvage, and high-dose consolidation or in the maintenance setting.
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Metadata
Title
A Review of Autologous Stem Cell Transplantation in Lymphoma
Authors
Umar Zahid
Faisal Akbar
Akshay Amaraneni
Muhammad Husnain
Onyee Chan
Irbaz Bin Riaz
Ali McBride
Ahmad Iftikhar
Faiz Anwer
Publication date
01-06-2017
Publisher
Springer US
Published in
Current Hematologic Malignancy Reports / Issue 3/2017
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-017-0382-1

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