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Current Gastroenterology Reports
Published in: Current Gastroenterology Reports 11/2019

Open Access 01-11-2019 | Motility Disorder | Esophagus (J Clarke and N Ahuja, Section Editors)

Neuronal Control of Esophageal Peristalsis and Its Role in Esophageal Disease

Authors: K. Nikaki, A. Sawada, A. Ustaoglu, D. Sifrim

Published in: Current Gastroenterology Reports | Issue 11/2019

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Abstract

Purpose of Review

Esophageal peristalsis is a highly sophisticated function that involves the coordinated contraction and relaxation of striated and smooth muscles in a cephalocaudal fashion, under the control of central and peripheral neuronal mechanisms and a number of neurotransmitters. Esophageal peristalsis is determined by the balance of the intrinsic excitatory cholinergic, inhibitory nitrergic and post-inhibitory rebound excitatory output to the esophageal musculature.

Recent Findings

Dissociation of the longitudinal and circular muscle contractions characterizes different major esophageal disorders and leads to esophageal symptoms. Provocative testing during esophageal high-resolution manometry is commonly employed to assess esophageal body peristaltic reserve and underpin clinical diagnosis.

Summary

Herein, we summarize the main factors that determine esophageal peristalsis and examine their role in major and minor esophageal motility disorders and eosinophilic esophagitis.
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Metadata
Title
Neuronal Control of Esophageal Peristalsis and Its Role in Esophageal Disease
Authors
K. Nikaki
A. Sawada
A. Ustaoglu
D. Sifrim
Publication date
01-11-2019
Publisher
Springer US
Published in
Current Gastroenterology Reports / Issue 11/2019
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-019-0728-z

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
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