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Current Gastroenterology Reports

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01-12-2018 | Liver (S Cotler and E Kallwitz, Section Editors)

Update on the Diagnosis and Management of Wilson Disease

Author: Eve A. Roberts

Published in: Current Gastroenterology Reports | Issue 12/2018

Abstract

Purpose of Review

Exciting developments relating to Wilson disease (WD) have taken place with respect to both basic biological and clinical research. This review critically examines some of these findings and considers their implications for current thinking about WD. It is not a comprehensive review of WD as a clinical disorder.

Recent Findings

The structure of the gene product of ATP7B, abnormal in WD, is being worked out in detail, along with a broader description of how the protein ATP7B (Wilson ATPase) functions in cells including enterocytes, not only in relation to copper disposition but also to lipid synthesis. Recent population studies raise the possibility that WD displays incomplete penetrance. Innovative screening techniques may increase ascertainment. New strategies for diagnosing and treating WD are being developed. Several disorders have been identified which might qualify as WD-mimics.

Summary

WD can be difficult to diagnose and treat. Insights from its pathobiology are providing new options for managing WD.

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Title: Update on the Diagnosis and Management of Wilson Disease
Author: Eve A. Roberts
Publication date: 01-12-2018
Publisher: Springer US
Published in: Current Gastroenterology Reports / Issue 12/2018
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI: https://doi.org/10.1007/s11894-018-0660-7

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