Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Current Gastroenterology Reports
Published in: Current Gastroenterology Reports 1/2015

01-01-2015 | Neurogastroenterology and Motility Disorders of the Gastrointestinal Tract (S Rao, Section Editor)

Gastric Electrical Stimulation for Obesity

Authors: Jenny D. Chiu, Edy Soffer

Published in: Current Gastroenterology Reports | Issue 1/2015

Login to get access

Abstract

Obesity is a growing health problem worldwide with a major impact on health and healthcare expenditures. Medical therapy in the form of diet and pharmacotherapy has limited effect on weight. Standard bariatric surgery is effective but is associated with morbidity and mortality, creating an unmet need for alternative therapies. One such therapy, the application of electrical stimulation to the stomach, has been studied extensively for the last two decades. Though pulse parameters differ between the various techniques used, the rationale behind this assumes that application of electrical current can interfere with gastric motor function or modulate afferent signaling to the brain or both. Initial studies led by industry failed to show an effect on body weight. However, more recently, there has been a renewed interest in this therapeutic modality with a number of concepts being evaluated in large human trials. If successful, this minimally invasive and low-risk intervention would be an important addition to the existing menu of therapies for obesity.
Literature
1.
2.
3.
Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States. J Am Med Assoc. 2014;311(8):806–14.CrossRef
4.
Dee A, Kearns K, O’Neill C, Sharp L, Staines A, O’Dwyer V, et al. The direct and indirect costs of both overweight and obesity: a systematic review. BMC Res Notes. 2014;7:242.PubMedCentralPubMedCrossRef
5.
Finkelstein EA, Trogdon JG, Cohen JW, Dietz W. Annual medical spending attributable to obesity payer-and-service-specific estimates. Health Aff (Millwood). 2009;28:w822–31.CrossRef
6.
Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes. 2008;32(9):1431–7.CrossRef
7.•
Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation. 2014;129(25 Suppl 2):S102–38. Annotation: A critical assessment of the medical and surgical management of overweight and obesity. The document is endorsed by many national societies and associations.PubMedCrossRef
8.
Guaraldi F, Pagotto U, Pasquali R. Predictors of weight loss and maintenance in patients treated with antiobesity drugs. Diabetes Metab Syndr Obes Tarets Ther. 2011;4:229–43.CrossRef
9.
Sarwer DB, Green AVS, Vetter ML, Wadden TA. Behavior therapy for obesity: where are we now? Current opinion in endocrinology. Diabetes Obes. 2009;16(5):347–52.
10.
Wadden TA, Sternberg JA, Letizia KA, Stunkard AJ, Foster GD. Treatment of obesity by very low calorie diet, behavior therapy, and their combination: a five-year perspective. Int J Obes. 1989;13 Suppl 2:39–46.PubMed
11.
Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity. J Am Med Assoc. 2014;311(1):74–86.CrossRef
12.
Weintraub M, Sundaresan PR, Cox C. Long-term weight control study. Individual participant response patterns. Clin Pharmacol Ther. 1992;51(5):619–33.PubMedCrossRef
13.•
Chang SH, Stoll CRT, Song J, Varela JE, Eagon CJ, Colditz GA. The effectiveness and risks of bariatric surgery an updated systematic review and meta-analysis. 2003-2012. JAMA Surg. 2014;149(3):275–87. Annotation: Most recent assessment of mortality, complications, reoperations, weight loss, and remission following bariatric surgery, using up-to-date, comprehensive data and meta-analytic techniques.PubMedCrossRef
14.
Birkmeyer JD, Finks JF, O’Reilly A, Oerline M, Carlin A, Nunn A, et al. Surgical skill and complication rates after bariatric surgery. N Engl J Med. 2013;369:1434–42.PubMedCrossRef
15.
16.
Kumar N, Thompson CC. Endoscopic solutions for weight loss. Curr Opin Gastroenterol. 2011;27:407–11.PubMedCrossRef
17.
Coté GA, Edmundowicz SA. Emerging technology: endoluminal treatment of obesity. Gastrointest Endosc. 2009;70(5):991–9.PubMedCrossRef
18.
Pullan A, Cheng I, Yassi R, Buist M. Modelling gastrointestinal bioelectric activity. Prog Biophys Mol Biol. 2004;85(2–3):523–50.PubMedCrossRef
19.
Camilleri M. Integrated upper gastrointestinal response to food intake. Gastroenterology. 2006;131:640–58.PubMedCrossRef
20.•
Morton GJ, Meek TH, Schwartz MW. Neurobiology of food intake in health and disease. Nat Rev Neurosci. 2014;15:367–78. Annotation: Up to date review describing the control of food intake by energy homeostasis mechanisms in health and in times of stress, and impairment of such mechanisms in disorders of body weight.PubMedCrossRef
21.
Phillips RJ, Powly TL. Tension and stretch receptors in gastrointestinal smooth muscle: re-evaluating vagal mechanoreceptors electrophysiology. Brain Res Rev. 2000;34:1–26.PubMedCrossRef
22.
Gonzalez MF, Deutsch JA. Vagotomy abolishes cues of satiety produced by gastric distension. Science. 1981;212:1283–4.PubMedCrossRef
23.
Eagon JC, Kelly KA. Effects of gastric pacing on canine gastric motility and emptying. Am J Physiol. 1993;265:G767–74.PubMed
24.
McCallum RW, Chen JDZ, Lin Z, Schirmer BD, Williams RD, Ross RA. Gastric pacing improves emptying and symptoms in patients with gastroparesis. Gastroenterology. 1998;114:456–61.PubMedCrossRef
25.
Yao S, Ke M, Wang Z, Xu D, Zhang Y, Chen JDZ. Retrograde gastric pacing reduces food intake and delays gastric emptying in humans: a potential therapy for obesity? Dig Dis Sci. 2005;50:1569–75.PubMedCrossRef
26.
Xing JH, Brody F, Brodsky J, Ponsky Soffer EE. The effect of gastric electrical stimulation on canine gastric emptying, food intake, and body weight. Obes Res. 2003;11:41–7.PubMedCrossRef
27.
Onen D, Jalilian D, Neshev E, Mintchev MP. Parametric study of neural gastric electrical stimulation in acute canine models. Trans Biomed Eng. 2007;54(3):429–35.CrossRef
28.
Peles S, Petersen J, Aviv R, Policker S, Abu-Hatoum O, Ben-Haimm SA, et al. Enhancement of antral contractions and vagal afferent signaling with synchronized electrical stimulation. Am J Physiol Gastrointest Liver Physiol. 2003;285:G577–85.PubMed
29.
Bohdjalian A, Prager G, Ricardo A, Policker S, Schindler K, Kretschmer S, et al. One-year experience with Tantalus™: a new surgical approach to treat morbid obesity. Obes Surg. 2006;16:627–34.PubMedCrossRef
30.
Burneo JG, Faught E, Knowlton R, Morawetz R, Kuzniecky R. Weight loss associated with vagus nerve stimulation. Neurology. 2002;59:463–4.PubMedCrossRef
31.
Sarr MG, Billington CJ, Brancatisano R, Brancatisano A, Toouli J, Kow L, et al. The EMPOWER study: randomized, prospective, double-blind, multicenter trial of vagal blockade to induce weight loss in morbid obesity. Obes Surg. 2012;22:1771–82.PubMedCrossRef
32.
Cigaina V, Hirschberg AL. Plasma ghrelin and gastric pacing in morbidly obese patients. Metab Clin Exp. 2007;56:1017–21.PubMedCrossRef
33.
Sanmiguel CP, Haddad W, Aviv R, Cunneen S, Phillips EH, Kapella W, et al. The TANTALUS™ system for obesity: effect on gastric emptying of solids and Ghrelin plasma levels. Obes Surg. 2007;17:1503–9.PubMedCrossRef
34.
Xing J, Felsher J, Brody F, Soffer EE. The effect of gastric electrical stimulation on lower esophageal sphincter pressure and release of regulatory peptides in a canine model. Dig Dis Sci. 2005;50:1481–7.PubMedCrossRef
35.
Liu S, Hou X, Chen JDZ. Therapeutic potential of duodenal electrical stimulation for obesity: acute effects on gastric emptying and water intake. Am J Gastroenterol. 2005;100(4):792–6.PubMedCrossRef
36.
Shikora SA, Bergenstal R, Bessler M, Brody F, Foster G, Frank A, et al. Implantable gastric stimulation for the treatment of clinically severe obesity: results of the SHAPE trial. Surg Obes Relat Dis. 2009;5(1):31–7.PubMedCrossRef
37.
38.
Tweden KS, Anvari M, Bierk MD, Billington CJ, Camilleri M, Honda CN, et al. Vagal blocking for obesity control (VBLOC): concordance of effects of very high frequency blocking current at the neural and organ levels using two preclinical models. Gastroenterology. 2006;130:A-148.
39.
Camilleri M, Toouli J, Herrera MF, Kulseng B, Kow L, Pantoja JP, et al. Intra-abdominal vagal blocking (VBLOC therapy): clinical results with a new implantable medical device. Surgery. 2008;143(6):723–31.PubMedCrossRef
40.
Camilleri M, Toouli J, Herrera MF, Kow L, Pantoja JP, Bilington CJ, et al. Selection of electrical algorithms to treat obesity with intermittent vagal block using an implantable medical device. Surg Obes Relat Dis. 2009;5(2):224–9.PubMedCrossRef
Metadata
Title
Gastric Electrical Stimulation for Obesity
Authors
Jenny D. Chiu
Edy Soffer
Publication date
01-01-2015
Publisher
Springer US
Published in
Current Gastroenterology Reports / Issue 1/2015
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-014-0424-y

Other articles of this Issue 1/2015

Current Gastroenterology Reports 1/2015 Go to the issue

Nutrition and Obesity (S McClave, Section Editor)

The Paradox of Artificial Sweeteners in Managing Obesity

Small Intestine (J Sellin, Section Editor)

Intestine and Multivisceral Transplantation: Current Status and Future Directions

Pancreas/Biliary Tract (O Haluzska, Section Editor)

Endoscopic Management of Benign Biliary Strictures

Pancreas and Biliary Tract (O Haluszka, Section Editor)

Endoscopic Treatment of Malignant Biliary Strictures
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits