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Current Gastroenterology Reports
Published in: Current Gastroenterology Reports 3/2014

01-03-2014 | GI Oncology (R Bresalier, Section Editor)

Interval Colorectal Cancers: What and Why

Authors: Chantal M. C. le Clercq, Silvia Sanduleanu

Published in: Current Gastroenterology Reports | Issue 3/2014

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Abstract

An increasing number of studies now indicate that colonoscopic examination is not perfect in preventing colorectal cancer (CRC), especially of the proximal colon. Several factors can be implicated in the occurrence of interval CRCs—further referred to as postcolonoscopy CRCs-, such as missed, incompletely resected lesions and newly developed cancers. Missed lesions represent by far the dominant cause of postcolonoscopy CRCs, with nonpolypoid (flat or depressed) neoplasms and sessile serrated polyps playing a significant role. Molecular events underlying progression of such lesions may further augment the cancer risk. In this article, we review the literature about postcolonoscopy CRC risk and the most common explanations. We discuss potential implications, paying special attention to improvements required in education and training.
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Metadata
Title
Interval Colorectal Cancers: What and Why
Authors
Chantal M. C. le Clercq
Silvia Sanduleanu
Publication date
01-03-2014
Publisher
Springer US
Published in
Current Gastroenterology Reports / Issue 3/2014
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-014-0375-3
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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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