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01-06-2013 | PEDIATRIC GASTROENTEROLOGY (S ORENSTEIN, SECTION EDITOR)

The Role of the Environment in the Development of Pediatric Inflammatory Bowel Disease

Authors: Amiirah Aujnarain, David R. Mack, Eric I. Benchimol

Published in: Current Gastroenterology Reports | Issue 6/2013

Abstract

The incidence of inflammatory bowel disease (IBD) is rising worldwide, with a particularly sharp increase in children. Rates are highest in North America and Europe, with rapid increases noted in developing nations adopting the Westernized environment. While many genetic risk loci have been identified that predispose people to IBD, incomplete penetrance and overlapping genotypes among patients with different phenotypes inadequately explain the etiology of these chronic diseases. Therefore, environmental risk factors have been the subject of much recent research. This article reviews the role of the environment in IBD, with particular focus on early-life exposures and pediatric-onset disease. The literature surrounding environmental risk factors is reviewed, including prenatal and perinatal exposures, the hygiene hypothesis, the urban environment, infection and antibiotic use, and secondhand tobacco smoke exposure. In addition, the possible role of the environment in altering the intestinal microbiome is addressed.

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Title: The Role of the Environment in the Development of Pediatric Inflammatory Bowel Disease
Authors: Amiirah Aujnarain
David R. Mack
Eric I. Benchimol
Publication date: 01-06-2013
Publisher: Current Science Inc.
Published in: Current Gastroenterology Reports / Issue 6/2013
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI: https://doi.org/10.1007/s11894-013-0326-4

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