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Current Gastroenterology Reports
Published in: Current Gastroenterology Reports 3/2013

01-03-2013 | Inflammatory Bowel Disease (S Hanauer, Section Editor)

What Can We Learn From Inflammatory Bowel Disease in Developing Countries?

Authors: Sunny H. Wong, Siew C. Ng

Published in: Current Gastroenterology Reports | Issue 3/2013

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Abstract

Inflammatory bowel diseases occur due to an aberrant immune response to luminal antigens in genetically predisposed individuals. Although specific genetic loci have been identified underlying the predisposition, they have not fully explained the disease etiology. Striking epidemiological observations implicate the critical role of environmental influences on disease penetrance. The emergence of disease consistently observed as a society becomes modernized or developed may be attributed to westernization of diet, changing antibiotic use, or improved hygiene status. These factors are linked with changes in the gastrointestinal microbiota which, in turn, may affect development of the immune system and influence the risk of disease occurrence. Geographic variations within developing countries suggest that the strength of influence by risk factors in a society varies greatly. Studies of IBD in populations of developing countries where there are opportunities to prospectively collect changing exposure data over time may provide clues to the disease etiology.
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Metadata
Title
What Can We Learn From Inflammatory Bowel Disease in Developing Countries?
Authors
Sunny H. Wong
Siew C. Ng
Publication date
01-03-2013
Publisher
Current Science Inc.
Published in
Current Gastroenterology Reports / Issue 3/2013
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-013-0313-9
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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