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Published in: Current Gastroenterology Reports 5/2011

01-10-2011

Review of the Microscopic Colitides

Authors: Eugene F. Yen, Darrell S. Pardi

Published in: Current Gastroenterology Reports | Issue 5/2011

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Abstract

Microscopic colitis is a common cause of chronic diarrhea in predominantly older adults. Incidence rates of microscopic colitis (including lymphocytic and collagenous colitis) have increased over time to levels comparable to other forms of inflammatory bowel disease. The possibility of drug-induced microscopic colitis is an important consideration when evaluating these patients, although this concept requires further investigation. There are few controlled treatment trials in microscopic colitis, with much of the data on treatment coming from retrospective studies. In patients with microscopic colitis, a systematic approach to therapy often leads to satisfactory control of symptoms. In this review, we will provide an updated assessment of the epidemiology, diagnosis, and treatment of microscopic colitis.
Literature
1.
go back to reference Pardi DS, Loftus Jr EV, Smyrk TC, et al. The epidemiology of microscopic colitis: a population based study in Olmsted County, Minnesota. Gut. 2007;56:504–8.PubMedCrossRef Pardi DS, Loftus Jr EV, Smyrk TC, et al. The epidemiology of microscopic colitis: a population based study in Olmsted County, Minnesota. Gut. 2007;56:504–8.PubMedCrossRef
2.
go back to reference Fernandez-Banares F, Salas A, Forne M, et al. Incidence of collagenous and lymphocytic colitis: a 5-year population-based study. Am J Gastroenterol. 1999;94:418–23.PubMed Fernandez-Banares F, Salas A, Forne M, et al. Incidence of collagenous and lymphocytic colitis: a 5-year population-based study. Am J Gastroenterol. 1999;94:418–23.PubMed
3.
go back to reference Williams JJ, Kaplan GG, Makhija S, et al. Microscopic colitis-defining incidence rates and risk factors: a population-based study. Clin Gastroenterol Hepatol. 2008;6:35–40.PubMedCrossRef Williams JJ, Kaplan GG, Makhija S, et al. Microscopic colitis-defining incidence rates and risk factors: a population-based study. Clin Gastroenterol Hepatol. 2008;6:35–40.PubMedCrossRef
4.
go back to reference Loftus Jr EV. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 2004;126:1504–17.PubMedCrossRef Loftus Jr EV. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 2004;126:1504–17.PubMedCrossRef
5.
go back to reference Limsui D, Pardi DS, Camilleri M, et al. Symptomatic overlap between irritable bowel syndrome and microscopic colitis. Inflamm Bowel Dis. 2007;13:175–81.PubMedCrossRef Limsui D, Pardi DS, Camilleri M, et al. Symptomatic overlap between irritable bowel syndrome and microscopic colitis. Inflamm Bowel Dis. 2007;13:175–81.PubMedCrossRef
6.
go back to reference • Chey WD, Nojkov B, Rubenstein JH, et al. The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trial. Am J Gastroenterol. 105:859–65. The first study to prospectively evaluate the yield of colonoscopy in patients with irritable bowel syndrome symptoms, with 2.3% of patients over age 45 being diagnosed with microscopic colitis. • Chey WD, Nojkov B, Rubenstein JH, et al. The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trial. Am J Gastroenterol. 105:859–65. The first study to prospectively evaluate the yield of colonoscopy in patients with irritable bowel syndrome symptoms, with 2.3% of patients over age 45 being diagnosed with microscopic colitis.
7.
go back to reference Yen EF, Pokhrel B, Bianchi LK, et al. Concomitant adenoma rates in patients with microscopic colitis. Gastroenterology. 2009;136:A-20.CrossRef Yen EF, Pokhrel B, Bianchi LK, et al. Concomitant adenoma rates in patients with microscopic colitis. Gastroenterology. 2009;136:A-20.CrossRef
8.
go back to reference Olesen M, Eriksson S, Bohr J, et al. Lymphocytic colitis: a retrospective clinical study of 199 Swedish patients. Gut. 2004;53:536–41.PubMedCrossRef Olesen M, Eriksson S, Bohr J, et al. Lymphocytic colitis: a retrospective clinical study of 199 Swedish patients. Gut. 2004;53:536–41.PubMedCrossRef
9.
go back to reference Agnarsdottir M, Gunnlaugsson O, Orvar KB, et al. Collagenous and lymphocytic colitis in Iceland. Dig Dis Sci. 2002;47:1122–8.PubMedCrossRef Agnarsdottir M, Gunnlaugsson O, Orvar KB, et al. Collagenous and lymphocytic colitis in Iceland. Dig Dis Sci. 2002;47:1122–8.PubMedCrossRef
10.
go back to reference Bohr J, Tysk C, Eriksson S, et al. Collagenous colitis in Orebro, Sweden, an epidemiological study 1984–1993. Gut. 1995;37:394–7.PubMedCrossRef Bohr J, Tysk C, Eriksson S, et al. Collagenous colitis in Orebro, Sweden, an epidemiological study 1984–1993. Gut. 1995;37:394–7.PubMedCrossRef
11.
go back to reference Bohr J, Tysk C, Eriksson S, et al. Collagenous colitis: a retrospective study of clinical presentation and treatment in 163 patients. Gut. 1996;39:846–51.PubMedCrossRef Bohr J, Tysk C, Eriksson S, et al. Collagenous colitis: a retrospective study of clinical presentation and treatment in 163 patients. Gut. 1996;39:846–51.PubMedCrossRef
12.
go back to reference Gremse DA, Boudreaux CW, Manci EA. Collagenous colitis in children. Gastroenterology. 1993;104:906–9.PubMed Gremse DA, Boudreaux CW, Manci EA. Collagenous colitis in children. Gastroenterology. 1993;104:906–9.PubMed
13.
go back to reference Madisch A, Heymer P, Voss C, et al. Oral budesonide therapy improves quality of life in patients with collagenous colitis. Int J Colorectal Dis. 2005;20:312–6.PubMedCrossRef Madisch A, Heymer P, Voss C, et al. Oral budesonide therapy improves quality of life in patients with collagenous colitis. Int J Colorectal Dis. 2005;20:312–6.PubMedCrossRef
14.
go back to reference • Hjortswang H, Tysk C, Bohr J, et al. Health-related quality of life is impaired in active collagenous colitis. Dig Liver Dis. 2010;43:102–9. A cross sectional study with 116 patients with collagenous colitis, the first major paper to illustrate the extent of quality of life impairment in patients with microscopic colitis. PubMedCrossRef • Hjortswang H, Tysk C, Bohr J, et al. Health-related quality of life is impaired in active collagenous colitis. Dig Liver Dis. 2010;43:102–9. A cross sectional study with 116 patients with collagenous colitis, the first major paper to illustrate the extent of quality of life impairment in patients with microscopic colitis. PubMedCrossRef
15.
go back to reference Baert F, Wouters K, D’Haens G, et al. Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis. Gut. 1999;45:375–81.PubMedCrossRef Baert F, Wouters K, D’Haens G, et al. Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis. Gut. 1999;45:375–81.PubMedCrossRef
16.
go back to reference • Miehlke S, Heymer P, Bethke B, et al. Budesonide treatment for collagenous colitis: a randomized, double-blind, placebo-controlled, multicenter trial. Gastroenterology. 2002;123:978–84.PubMedCrossRef • Miehlke S, Heymer P, Bethke B, et al. Budesonide treatment for collagenous colitis: a randomized, double-blind, placebo-controlled, multicenter trial. Gastroenterology. 2002;123:978–84.PubMedCrossRef
17.
go back to reference • Bonderup OK, Hansen JB, Birket-Smith L, et al. Budesonide treatment of collagenous colitis: a randomised, double blind, placebo controlled trial with morphometric analysis. Gut. 2003;52:248–51.PubMedCrossRef • Bonderup OK, Hansen JB, Birket-Smith L, et al. Budesonide treatment of collagenous colitis: a randomised, double blind, placebo controlled trial with morphometric analysis. Gut. 2003;52:248–51.PubMedCrossRef
18.
go back to reference • Baert F, Schmit A, D’Haens G, et al. Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up. Gastroenterology. 2002;122:20–5.PubMedCrossRef • Baert F, Schmit A, D’Haens G, et al. Budesonide in collagenous colitis: a double-blind placebo-controlled trial with histologic follow-up. Gastroenterology. 2002;122:20–5.PubMedCrossRef
19.
go back to reference • Miehlke S, Madisch A, Karimi D, et al. Budesonide is effective in treating lymphocytic colitis: a randomized double-blind placebo-controlled study. Gastroenterology. 2009;136:2092–100. The preceding four studies (16–19) represent the largest randomized placebo-controlled studies to date on the treatment of microscopic colitis, all using budesonide. PubMedCrossRef • Miehlke S, Madisch A, Karimi D, et al. Budesonide is effective in treating lymphocytic colitis: a randomized double-blind placebo-controlled study. Gastroenterology. 2009;136:2092–100. The preceding four studies (16–19) represent the largest randomized placebo-controlled studies to date on the treatment of microscopic colitis, all using budesonide. PubMedCrossRef
20.
go back to reference • Miehlke S, Madisch A, Bethke B, et al. Oral budesonide for maintenance treatment of collagenous colitis: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2008;135:1510–6.PubMedCrossRef • Miehlke S, Madisch A, Bethke B, et al. Oral budesonide for maintenance treatment of collagenous colitis: a randomized, double-blind, placebo-controlled trial. Gastroenterology. 2008;135:1510–6.PubMedCrossRef
21.
go back to reference • Bonderup OK, Hansen JB, Teglbjaerg PS, et al. Long-term budesonide treatment of collagenous colitis: a randomised, double-blind, placebo-controlled trial. Gut. 2009;58:68–72. The preceding 2 studies are placebo-controlled studies involving budesonide for maintenance of remission in microscopic colitis. PubMedCrossRef • Bonderup OK, Hansen JB, Teglbjaerg PS, et al. Long-term budesonide treatment of collagenous colitis: a randomised, double-blind, placebo-controlled trial. Gut. 2009;58:68–72. The preceding 2 studies are placebo-controlled studies involving budesonide for maintenance of remission in microscopic colitis. PubMedCrossRef
22.
go back to reference Chan JL, Tersmette AC, Offerhaus GJ, et al. Cancer risk in collagenous colitis. Inflamm Bowel Dis. 1999;5:40–3.PubMedCrossRef Chan JL, Tersmette AC, Offerhaus GJ, et al. Cancer risk in collagenous colitis. Inflamm Bowel Dis. 1999;5:40–3.PubMedCrossRef
23.
go back to reference Kao KT, Pedraza BA, McClune AC, et al. Microscopic colitis: a large retrospective analysis from a health maintenance organization experience. World J Gastroenterol. 2009;15:3122–7.PubMedCrossRef Kao KT, Pedraza BA, McClune AC, et al. Microscopic colitis: a large retrospective analysis from a health maintenance organization experience. World J Gastroenterol. 2009;15:3122–7.PubMedCrossRef
24.
go back to reference Pardi DS, Ramnath VR, Loftus Jr EV, et al. Lymphocytic colitis: clinical features, treatment, and outcomes. Am J Gastroenterol. 2002;97:2829–33.PubMedCrossRef Pardi DS, Ramnath VR, Loftus Jr EV, et al. Lymphocytic colitis: clinical features, treatment, and outcomes. Am J Gastroenterol. 2002;97:2829–33.PubMedCrossRef
25.
go back to reference Wolber R, Owen D, Freeman H. Colonic lymphocytosis in patients with celiac sprue. Hum Pathol. 1990;21:1092–6.PubMedCrossRef Wolber R, Owen D, Freeman H. Colonic lymphocytosis in patients with celiac sprue. Hum Pathol. 1990;21:1092–6.PubMedCrossRef
26.
go back to reference Green PH, Yang J, Cheng J, et al. An association between microscopic colitis and celiac disease. Clin Gastroenterol Hepatol. 2009;7:1210–6.PubMedCrossRef Green PH, Yang J, Cheng J, et al. An association between microscopic colitis and celiac disease. Clin Gastroenterol Hepatol. 2009;7:1210–6.PubMedCrossRef
27.
go back to reference Bohr J, Tysk C, Yang P, et al. Autoantibodies and immunoglobulins in collagenous colitis. Gut. 1996;39:73–6.PubMedCrossRef Bohr J, Tysk C, Yang P, et al. Autoantibodies and immunoglobulins in collagenous colitis. Gut. 1996;39:73–6.PubMedCrossRef
28.
go back to reference Fine KD, Do K, Schulte K, et al. High prevalence of celiac sprue-like HLA-DQ genes and enteropathy in patients with the microscopic colitis syndrome. Am J Gastroenterol. 2000;95:1974–82.PubMedCrossRef Fine KD, Do K, Schulte K, et al. High prevalence of celiac sprue-like HLA-DQ genes and enteropathy in patients with the microscopic colitis syndrome. Am J Gastroenterol. 2000;95:1974–82.PubMedCrossRef
29.
go back to reference Pardi DS, Loftus Jr EV, Kammer PP, et al. Collagenous colitis, but not lymphocytic colitis, is associated with cigarette smoking [abstract]. Am J Gastroenterol. 2004;99:S116.CrossRef Pardi DS, Loftus Jr EV, Kammer PP, et al. Collagenous colitis, but not lymphocytic colitis, is associated with cigarette smoking [abstract]. Am J Gastroenterol. 2004;99:S116.CrossRef
30.
go back to reference Pokhrel B, Witt B, Bianchi LK, et al. Microscopic colitis and association with cigarette smoking and alcohol intake [abstract]. Am J Gastroenterol. 2009;104:S453–4. Pokhrel B, Witt B, Bianchi LK, et al. Microscopic colitis and association with cigarette smoking and alcohol intake [abstract]. Am J Gastroenterol. 2009;104:S453–4.
31.
go back to reference Jarnerot G, Tysk C, Bohr J, et al. Collagenous colitis and fecal stream diversion. Gastroenterology. 1995;109:449–55.PubMedCrossRef Jarnerot G, Tysk C, Bohr J, et al. Collagenous colitis and fecal stream diversion. Gastroenterology. 1995;109:449–55.PubMedCrossRef
32.
go back to reference Mosnier JF, Larvol L, Barge J, et al. Lymphocytic and collagenous colitis: an immunohistochemical study. Am J Gastroenterol. 1996;91:709–13.PubMed Mosnier JF, Larvol L, Barge J, et al. Lymphocytic and collagenous colitis: an immunohistochemical study. Am J Gastroenterol. 1996;91:709–13.PubMed
33.
go back to reference Beaugerie L, Pardi DS. Review article: drug-induced microscopic colitis—proposal for a scoring system and review of the literature. Aliment Pharmacol Ther. 2005;22:277–84.PubMedCrossRef Beaugerie L, Pardi DS. Review article: drug-induced microscopic colitis—proposal for a scoring system and review of the literature. Aliment Pharmacol Ther. 2005;22:277–84.PubMedCrossRef
34.
go back to reference Fernandez-Banares F, Esteve M, Espinos JC, et al. Drug consumption and the risk of microscopic colitis. Am J Gastroenterol. 2007;102:324–30.PubMedCrossRef Fernandez-Banares F, Esteve M, Espinos JC, et al. Drug consumption and the risk of microscopic colitis. Am J Gastroenterol. 2007;102:324–30.PubMedCrossRef
35.
go back to reference Riddell RH, Tanaka M, Mazzoleni G. Non-steroidal anti-inflammatory drugs as a possible cause of collagenous colitis: a case-control study. Gut. 1992;33:683–6.PubMedCrossRef Riddell RH, Tanaka M, Mazzoleni G. Non-steroidal anti-inflammatory drugs as a possible cause of collagenous colitis: a case-control study. Gut. 1992;33:683–6.PubMedCrossRef
36.
go back to reference Bjarnason I, Hayllar J, MacPherson AJ, et al. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology. 1993;104:1832–47.PubMed Bjarnason I, Hayllar J, MacPherson AJ, et al. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology. 1993;104:1832–47.PubMed
37.
go back to reference Yagi K, Nakamura A, Sekine A, et al. Nonsteroidal anti-inflammatory drug-associated colitis with a histology of collagenous colitis. Endoscopy. 2001;33:629–32.PubMedCrossRef Yagi K, Nakamura A, Sekine A, et al. Nonsteroidal anti-inflammatory drug-associated colitis with a histology of collagenous colitis. Endoscopy. 2001;33:629–32.PubMedCrossRef
38.
go back to reference Al-Ghamdi MY, Malatjalian DA, Veldhuyzen van Zanten S. Causation: recurrent collagenous colitis following repeated use of NSAIDs. Can J Gastroenterol. 2002;16:861–2.PubMed Al-Ghamdi MY, Malatjalian DA, Veldhuyzen van Zanten S. Causation: recurrent collagenous colitis following repeated use of NSAIDs. Can J Gastroenterol. 2002;16:861–2.PubMed
39.
go back to reference Pascua MF, Kedia P, Weiner M, et al. Microscopic colitis and medication use. Gastroenterology. 2009;136:A-366.CrossRef Pascua MF, Kedia P, Weiner M, et al. Microscopic colitis and medication use. Gastroenterology. 2009;136:A-366.CrossRef
40.
go back to reference Pignone M, Anderson GK, Binns K, et al. Aspirin use among adults aged 40 and older in the United States: results of a national survey. Am J Prev Med. 2007;32:403–7.PubMedCrossRef Pignone M, Anderson GK, Binns K, et al. Aspirin use among adults aged 40 and older in the United States: results of a national survey. Am J Prev Med. 2007;32:403–7.PubMedCrossRef
41.
go back to reference Lundberg JO, Herulf M, Olesen M, et al. Increased nitric oxide production in collagenous and lymphocytic colitis. Eur J Clin Invest. 1997;27:869–71.PubMedCrossRef Lundberg JO, Herulf M, Olesen M, et al. Increased nitric oxide production in collagenous and lymphocytic colitis. Eur J Clin Invest. 1997;27:869–71.PubMedCrossRef
42.
go back to reference Olesen M, Middelveld R, Bohr J, et al. Luminal nitric oxide and epithelial expression of inducible and endothelial nitric oxide synthase in collagenous and lymphocytic colitis. Scand J Gastroenterol. 2003;38:66–72.PubMedCrossRef Olesen M, Middelveld R, Bohr J, et al. Luminal nitric oxide and epithelial expression of inducible and endothelial nitric oxide synthase in collagenous and lymphocytic colitis. Scand J Gastroenterol. 2003;38:66–72.PubMedCrossRef
43.
go back to reference Perner A, Andresen L, Normark M, et al. Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. Gut. 2001;49:387–94.PubMedCrossRef Perner A, Andresen L, Normark M, et al. Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis. Gut. 2001;49:387–94.PubMedCrossRef
44.
go back to reference Burgel N, Bojarski C, Mankertz J, et al. Mechanisms of diarrhea in collagenous colitis. Gastroenterology. 2002;123:433–43.PubMedCrossRef Burgel N, Bojarski C, Mankertz J, et al. Mechanisms of diarrhea in collagenous colitis. Gastroenterology. 2002;123:433–43.PubMedCrossRef
45.
go back to reference Marteau P, Lavergne-Slove A, Lemann M, et al. Primary ileal villous atrophy is often associated with microscopic colitis. Gut. 1997;41:561–4.PubMedCrossRef Marteau P, Lavergne-Slove A, Lemann M, et al. Primary ileal villous atrophy is often associated with microscopic colitis. Gut. 1997;41:561–4.PubMedCrossRef
46.
go back to reference Ung KA, Gillberg R, Kilander A, et al. Role of bile acids and bile acid binding agents in patients with collagenous colitis. Gut. 2000;46:170–5.PubMedCrossRef Ung KA, Gillberg R, Kilander A, et al. Role of bile acids and bile acid binding agents in patients with collagenous colitis. Gut. 2000;46:170–5.PubMedCrossRef
47.
go back to reference Gwee KA, Collins SM, Read NW, et al. Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome. Gut. 2003;52:523–6.PubMedCrossRef Gwee KA, Collins SM, Read NW, et al. Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome. Gut. 2003;52:523–6.PubMedCrossRef
48.
go back to reference Spiller RC, Jenkins D, Thornley JP, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 2000;47:804–11.PubMedCrossRef Spiller RC, Jenkins D, Thornley JP, et al. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 2000;47:804–11.PubMedCrossRef
49.
go back to reference Aigner T, Neureiter D, Muller S, et al. Extracellular matrix composition and gene expression in collagenous colitis. Gastroenterology. 1997;113:136–43.PubMedCrossRef Aigner T, Neureiter D, Muller S, et al. Extracellular matrix composition and gene expression in collagenous colitis. Gastroenterology. 1997;113:136–43.PubMedCrossRef
50.
go back to reference Salas A, Fernandez-Banares F, Casalots J, et al. Subepithelial myofibroblasts and tenascin expression in microscopic colitis. Histopathology. 2003;43:48–54.PubMedCrossRef Salas A, Fernandez-Banares F, Casalots J, et al. Subepithelial myofibroblasts and tenascin expression in microscopic colitis. Histopathology. 2003;43:48–54.PubMedCrossRef
51.
go back to reference Lee E, Schiller LR, Vendrell D, et al. Subepithelial collagen table thickness in colon specimens from patients with microscopic colitis and collagenous colitis. Gastroenterology. 1992;103:1790–6.PubMed Lee E, Schiller LR, Vendrell D, et al. Subepithelial collagen table thickness in colon specimens from patients with microscopic colitis and collagenous colitis. Gastroenterology. 1992;103:1790–6.PubMed
52.
go back to reference Couto G, Bispo M, Barreiro P, et al. Unique endoscopy findings in collagenous colitis. Gastrointest Endosc. 2009;69:1186–8.PubMedCrossRef Couto G, Bispo M, Barreiro P, et al. Unique endoscopy findings in collagenous colitis. Gastrointest Endosc. 2009;69:1186–8.PubMedCrossRef
53.
go back to reference • Carmack SW, Lash RH, Gulizia JM, et al. Lymphocytic disorders of the gastrointestinal tract: a review for the practicing pathologist. Adv Anat Pathol. 2009;16:290–306. A thorough update of the etiologies of lymphocytic infiltration in the GI tract, reviewing that intra-epithelial lymphocytes can be associated with conditions other than microscopic colitis. PubMedCrossRef • Carmack SW, Lash RH, Gulizia JM, et al. Lymphocytic disorders of the gastrointestinal tract: a review for the practicing pathologist. Adv Anat Pathol. 2009;16:290–306. A thorough update of the etiologies of lymphocytic infiltration in the GI tract, reviewing that intra-epithelial lymphocytes can be associated with conditions other than microscopic colitis. PubMedCrossRef
54.
go back to reference Fine KD, Lee EL, Meyer RL. Colonic histopathology in untreated celiac sprue or refractory sprue: is it lymphocytic colitis or colonic lymphocytosis? Hum Pathol. 1998;29:1433–40.PubMedCrossRef Fine KD, Lee EL, Meyer RL. Colonic histopathology in untreated celiac sprue or refractory sprue: is it lymphocytic colitis or colonic lymphocytosis? Hum Pathol. 1998;29:1433–40.PubMedCrossRef
55.
go back to reference Matteoni CA, Wang N, Goldblum JR, et al. Flexible sigmoidoscopy for the detection of microscopic colitis. Am J Med. 2000;108:416–8.PubMedCrossRef Matteoni CA, Wang N, Goldblum JR, et al. Flexible sigmoidoscopy for the detection of microscopic colitis. Am J Med. 2000;108:416–8.PubMedCrossRef
56.
go back to reference Tanaka M, Mazzoleni G, Riddell RH. Distribution of collagenous colitis: utility of flexible sigmoidoscopy. Gut. 1992;33:65–70.PubMedCrossRef Tanaka M, Mazzoleni G, Riddell RH. Distribution of collagenous colitis: utility of flexible sigmoidoscopy. Gut. 1992;33:65–70.PubMedCrossRef
57.
go back to reference Thijs WJ, van Baarlen J, Kleibeuker JH, et al. Microscopic colitis: prevalence and distribution throughout the colon in patients with chronic diarrhoea. Neth J Med. 2005;63:137–40.PubMed Thijs WJ, van Baarlen J, Kleibeuker JH, et al. Microscopic colitis: prevalence and distribution throughout the colon in patients with chronic diarrhoea. Neth J Med. 2005;63:137–40.PubMed
58.
go back to reference Yen EF, Hall CR, Witt B. Yield of sigmoid and rectal biopsies in the detection of microscopic colitis. Gastroenterology. 2010;138:S638. Yen EF, Hall CR, Witt B. Yield of sigmoid and rectal biopsies in the detection of microscopic colitis. Gastroenterology. 2010;138:S638.
59.
go back to reference Fine KD, Lee EL. Efficacy of open-label bismuth subsalicylate for the treatment of microscopic colitis. Gastroenterology. 1998;114:29–36.PubMedCrossRef Fine KD, Lee EL. Efficacy of open-label bismuth subsalicylate for the treatment of microscopic colitis. Gastroenterology. 1998;114:29–36.PubMedCrossRef
60.
go back to reference Fernandez-Banares F, Esteve M, Salas A, et al. Bile acid malabsorption in microscopic colitis and in previously unexplained functional chronic diarrhea. Dig Dis Sci. 2001;46:2231–8.PubMedCrossRef Fernandez-Banares F, Esteve M, Salas A, et al. Bile acid malabsorption in microscopic colitis and in previously unexplained functional chronic diarrhea. Dig Dis Sci. 2001;46:2231–8.PubMedCrossRef
61.
go back to reference Calabrese C, Fabbri A, Areni A, et al. Mesalazine with or without cholestyramine in the treatment of microscopic colitis: randomized controlled trial. J Gastroenterol Hepatol. 2007;22:809–14.PubMedCrossRef Calabrese C, Fabbri A, Areni A, et al. Mesalazine with or without cholestyramine in the treatment of microscopic colitis: randomized controlled trial. J Gastroenterol Hepatol. 2007;22:809–14.PubMedCrossRef
62.
go back to reference Abdalla AA, Faubion WA, Loftus Jr EV, et al. The natural history of microscopic colitis treated with corticosteroids [abstract]. Gastroenterology. 2008;134:A121.CrossRef Abdalla AA, Faubion WA, Loftus Jr EV, et al. The natural history of microscopic colitis treated with corticosteroids [abstract]. Gastroenterology. 2008;134:A121.CrossRef
63.
go back to reference Munck LK, Kjeldsen J, Philipsen E, et al. Incomplete remission with short-term prednisolone treatment in collagenous colitis: a randomized study. Scand J Gastroenterol. 2003;38:606–10.PubMedCrossRef Munck LK, Kjeldsen J, Philipsen E, et al. Incomplete remission with short-term prednisolone treatment in collagenous colitis: a randomized study. Scand J Gastroenterol. 2003;38:606–10.PubMedCrossRef
64.
go back to reference Pardi DS, Loftus Jr EV, Tremaine WJ, et al. Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine. Gastroenterology. 2001;120:1483–4.PubMedCrossRef Pardi DS, Loftus Jr EV, Tremaine WJ, et al. Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine. Gastroenterology. 2001;120:1483–4.PubMedCrossRef
65.
go back to reference Rodriguez E, Mahadevan U. Anti-TNF therapy for refractory microscopic colitis. Gastroenterology. 2009;136:A663.CrossRef Rodriguez E, Mahadevan U. Anti-TNF therapy for refractory microscopic colitis. Gastroenterology. 2009;136:A663.CrossRef
66.
go back to reference Jarnerot G, Bohr J, Tysk C, et al. Faecal stream diversion in patients with collagenous colitis. Gut. 1996;38:154–5.PubMedCrossRef Jarnerot G, Bohr J, Tysk C, et al. Faecal stream diversion in patients with collagenous colitis. Gut. 1996;38:154–5.PubMedCrossRef
67.
go back to reference Williams RA, Gelfand DV. Total proctocolectomy and ileal pouch anal anastomosis to successfully treat a patient with collagenous colitis. Am J Gastroenterol. 2000;95:2147.PubMedCrossRef Williams RA, Gelfand DV. Total proctocolectomy and ileal pouch anal anastomosis to successfully treat a patient with collagenous colitis. Am J Gastroenterol. 2000;95:2147.PubMedCrossRef
Metadata
Title
Review of the Microscopic Colitides
Authors
Eugene F. Yen
Darrell S. Pardi
Publication date
01-10-2011
Publisher
Current Science Inc.
Published in
Current Gastroenterology Reports / Issue 5/2011
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-011-0207-7

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Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine