Skip to main content
Top
Published in: Current Gastroenterology Reports 6/2010

01-12-2010

The Status of Diagnostic Markers for Inflammatory Bowel Disease

Authors: Poonam Beniwal, Laura Harrell

Published in: Current Gastroenterology Reports | Issue 6/2010

Login to get access

Abstract

Inflammatory bowel disease (IBD), which includes ulcerative colitis, Crohn’s disease, and indeterminate colitis, is characterized by chronic inflammation of the digestive tract and has a significant impact on quality of life. Coupled with clinical history, physicians rely on invasive tests (e.g. endoscopy and radiologic examinations) to diagnose IBD. Patients with other gastrointestinal illnesses (e.g. irritable bowel syndrome and celiac disease) may present with symptoms similar to those of an IBD patient. Therefore, a need exists for rapid and noninvasive measures to indicate the presence of IBD. The identification of potential biomarkers associated with IBD has expanded rapidly in the past decade. This article reviews the role of recently studied serologic and fecal markers in the diagnosis of IBD, and differentiation between subtypes of IBD.
Literature
1.
go back to reference Papp M, Norman GL, Altorjay I, Lakatos PL: Utility of serological markers in inflammatory bowel diseases: gadget or magic? World J Gastroenterol 2007, 13:2028–2036.PubMed Papp M, Norman GL, Altorjay I, Lakatos PL: Utility of serological markers in inflammatory bowel diseases: gadget or magic? World J Gastroenterol 2007, 13:2028–2036.PubMed
2.
go back to reference Main J, McKenzie H, Yeaman GR, et al.: Antibody to Saccharomyces cerevisiae (baker’s yeast) in Crohn’s disease. BMJ 1988, 297:1105–1106.CrossRefPubMed Main J, McKenzie H, Yeaman GR, et al.: Antibody to Saccharomyces cerevisiae (baker’s yeast) in Crohn’s disease. BMJ 1988, 297:1105–1106.CrossRefPubMed
3.
go back to reference Saxon A, Shanahan F, Landers C, et al.: A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 1990, 86:202–210.CrossRefPubMed Saxon A, Shanahan F, Landers C, et al.: A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J Allergy Clin Immunol 1990, 86:202–210.CrossRefPubMed
4.
go back to reference Cambridge G, Rampton DS, Stevens TR, et al.: Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1992, 33:668–674.CrossRefPubMed Cambridge G, Rampton DS, Stevens TR, et al.: Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut 1992, 33:668–674.CrossRefPubMed
5.
go back to reference Harrell L: Evolving serological markers for IBD. Inflamm Bowel Dis Monit 2007, 8:42–48. Harrell L: Evolving serological markers for IBD. Inflamm Bowel Dis Monit 2007, 8:42–48.
6.
go back to reference Reese GE, Constantinides VA, Simillis C, et al.: Diagnostic precision of anti-Saccharomyces cerevisiae antibodies and perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease. Am J Gastroenterol 2006, 101:2410–2422.CrossRefPubMed Reese GE, Constantinides VA, Simillis C, et al.: Diagnostic precision of anti-Saccharomyces cerevisiae antibodies and perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease. Am J Gastroenterol 2006, 101:2410–2422.CrossRefPubMed
7.
go back to reference Joossens S, Reinisch W, Vermeire S, et al.: The value of serologic markers in indeterminate colitis: a prospective follow-up study. Gastroenterology 2002, 122:1242–1247.CrossRefPubMed Joossens S, Reinisch W, Vermeire S, et al.: The value of serologic markers in indeterminate colitis: a prospective follow-up study. Gastroenterology 2002, 122:1242–1247.CrossRefPubMed
8.
go back to reference Melmed GY, Fleshner P, Bardakcioglu O, et al.: Family history and serology predict Crohn’s disease after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum 2008, 51:100–108.CrossRefPubMed Melmed GY, Fleshner P, Bardakcioglu O, et al.: Family history and serology predict Crohn’s disease after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum 2008, 51:100–108.CrossRefPubMed
9.
go back to reference Hui T, Landers C, Vasiliauskas E, et al.: Serologic responses in indeterminate colitis patients before ileal pouch-anal anastomosis may determine those at risk for continuous pouch inflammation. Dis Colon Rectum 2005, 48:1254–1262.CrossRefPubMed Hui T, Landers C, Vasiliauskas E, et al.: Serologic responses in indeterminate colitis patients before ileal pouch-anal anastomosis may determine those at risk for continuous pouch inflammation. Dis Colon Rectum 2005, 48:1254–1262.CrossRefPubMed
10.
go back to reference Dotan N, Altstock RT, Schwarz M, Dukler A: Anti-glycan antibodies as biomarkers for diagnosis and prognosis. Lupus 2006, 15:442–450.CrossRefPubMed Dotan N, Altstock RT, Schwarz M, Dukler A: Anti-glycan antibodies as biomarkers for diagnosis and prognosis. Lupus 2006, 15:442–450.CrossRefPubMed
11.
go back to reference Dotan I, Fishman S, Dgani Y, et al.: Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn’s disease. Gastroenterology 2006, 131:366–378.CrossRefPubMed Dotan I, Fishman S, Dgani Y, et al.: Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn’s disease. Gastroenterology 2006, 131:366–378.CrossRefPubMed
12.
go back to reference • Ferrante M, Henckaerts L, Joossens M, et al.: New serological markers in inflammatory bowel disease are associated with complicated disease behaviour. Gut 2007, 56:1394–1403. This large study examined the association of the newer antiglycan markers and IBD, and was also the first to explore their relationship with complicated disease behavior. CrossRefPubMed • Ferrante M, Henckaerts L, Joossens M, et al.: New serological markers in inflammatory bowel disease are associated with complicated disease behaviour. Gut 2007, 56:1394–1403. This large study examined the association of the newer antiglycan markers and IBD, and was also the first to explore their relationship with complicated disease behavior. CrossRefPubMed
13.
go back to reference Seow CH, Stempak JM, Xu W, et al.: Novel anti-glycan antibodies related to inflammatory bowel disease diagnosis and phenotype. Am J Gastroenterol 2009, 104:1426–1434.CrossRefPubMed Seow CH, Stempak JM, Xu W, et al.: Novel anti-glycan antibodies related to inflammatory bowel disease diagnosis and phenotype. Am J Gastroenterol 2009, 104:1426–1434.CrossRefPubMed
14.
go back to reference Lodes MJ, Cong Y, Elson CO, et al.: Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 2004, 113:1296–1306.PubMed Lodes MJ, Cong Y, Elson CO, et al.: Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 2004, 113:1296–1306.PubMed
15.
go back to reference Targan SR, Landers CJ, Yang H, et al.: Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn’s disease. Gastroenterology 2005, 128:2020–2028.CrossRefPubMed Targan SR, Landers CJ, Yang H, et al.: Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn’s disease. Gastroenterology 2005, 128:2020–2028.CrossRefPubMed
16.
go back to reference Sutton CL, Kim J, Yamane A, et al.: Identification of a novel bacterial sequence associated with Crohn’s disease. Gastroenterology 2000, 119:23–31.CrossRefPubMed Sutton CL, Kim J, Yamane A, et al.: Identification of a novel bacterial sequence associated with Crohn’s disease. Gastroenterology 2000, 119:23–31.CrossRefPubMed
17.
go back to reference Iltanen S, Tervo L, Halttunen T, et al.: Elevated serum anti-I2 and anti-OmpW antibody levels in children with IBD. Inflamm Bowel Dis 2006, 12:389–394.CrossRefPubMed Iltanen S, Tervo L, Halttunen T, et al.: Elevated serum anti-I2 and anti-OmpW antibody levels in children with IBD. Inflamm Bowel Dis 2006, 12:389–394.CrossRefPubMed
18.
go back to reference Cohavy O, Bruckner D, Gordon LK, et al.: Colonic bacteria express an ulcerative colitis pANCA-related protein epitope. Infect Immun 2000, 68:1542–1548.CrossRefPubMed Cohavy O, Bruckner D, Gordon LK, et al.: Colonic bacteria express an ulcerative colitis pANCA-related protein epitope. Infect Immun 2000, 68:1542–1548.CrossRefPubMed
19.
go back to reference Zholudev A, Zurakowski D, Young W, et al.: Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn’s disease and ulcerative colitis: diagnostic value and correlation with disease phenotype. Am J Gastroenterol 2004, 99:2235–2241.CrossRefPubMed Zholudev A, Zurakowski D, Young W, et al.: Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn’s disease and ulcerative colitis: diagnostic value and correlation with disease phenotype. Am J Gastroenterol 2004, 99:2235–2241.CrossRefPubMed
20.
go back to reference García Sánchez Mdel V, González R, Iglesias Flores E, et al.: Diagnostic value of fecal calprotectin in predicting an abnormal colonoscopy. Med Clin (Barc) 2006, 127:41–46. García Sánchez Mdel V, González R, Iglesias Flores E, et al.: Diagnostic value of fecal calprotectin in predicting an abnormal colonoscopy. Med Clin (Barc) 2006, 127:41–46.
21.
go back to reference Røseth AG, Kristinsson J, Fagerhol MK, et al.: Faecal calprotectin: a novel test for the diagnosis of colorectal cancer? Scand J Gastroenterol 1993, 28:1073–1076.CrossRefPubMed Røseth AG, Kristinsson J, Fagerhol MK, et al.: Faecal calprotectin: a novel test for the diagnosis of colorectal cancer? Scand J Gastroenterol 1993, 28:1073–1076.CrossRefPubMed
22.
go back to reference • Foell D, Wittkowski H, Roth J: Monitoring disease activity by stool analyses: from occult blood to molecular markers of intestinal inflammation and damage. Gut 2009, 58:859–868. This article is a nice review of fecal markers and their role in monitoring disease activity in patients with IBD. This paper also reviews the biology of biomarkers and discusses newer markers on the horizon.CrossRefPubMed • Foell D, Wittkowski H, Roth J: Monitoring disease activity by stool analyses: from occult blood to molecular markers of intestinal inflammation and damage. Gut 2009, 58:859–868. This article is a nice review of fecal markers and their role in monitoring disease activity in patients with IBD. This paper also reviews the biology of biomarkers and discusses newer markers on the horizon.CrossRefPubMed
23.
go back to reference Erbayrak M, Turkay C, Eraslan E, et al.: The role of fecal calprotectin in investigating inflammatory bowel diseases. Clinics (Sao Paulo) 2009, 64:421–425. Erbayrak M, Turkay C, Eraslan E, et al.: The role of fecal calprotectin in investigating inflammatory bowel diseases. Clinics (Sao Paulo) 2009, 64:421–425.
24.
go back to reference • Diamanti A, Panetta F, Basso MS, et al.: Diagnostic work-up of inflammatory bowel disease in children: the role of calprotectin assay. Inflamm Bowel Dis 2010 (Epub ahead of print). This prospective study examines the diagnostic accuracy of calprotectin in children with gastrointestinal symptoms suggestive of IBD. • Diamanti A, Panetta F, Basso MS, et al.: Diagnostic work-up of inflammatory bowel disease in children: the role of calprotectin assay. Inflamm Bowel Dis 2010 (Epub ahead of print). This prospective study examines the diagnostic accuracy of calprotectin in children with gastrointestinal symptoms suggestive of IBD.
25.
go back to reference Schoepfer AM, Beglinger C, Straumann A, et al.: Fecal calprotectin correlates more closely with the Simple Endoscopic Score for Crohn’s disease (SES-CD) than CRP, blood leukocytes, and the CDAI. Am J Gastroenterol 2010, 105:162–169.CrossRefPubMed Schoepfer AM, Beglinger C, Straumann A, et al.: Fecal calprotectin correlates more closely with the Simple Endoscopic Score for Crohn’s disease (SES-CD) than CRP, blood leukocytes, and the CDAI. Am J Gastroenterol 2010, 105:162–169.CrossRefPubMed
26.
go back to reference Kane SV, Sandborn WJ, Rufo PA, et al.: Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation. Am J Gastroenterol 2003, 98:1309–1314.CrossRefPubMed Kane SV, Sandborn WJ, Rufo PA, et al.: Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation. Am J Gastroenterol 2003, 98:1309–1314.CrossRefPubMed
Metadata
Title
The Status of Diagnostic Markers for Inflammatory Bowel Disease
Authors
Poonam Beniwal
Laura Harrell
Publication date
01-12-2010
Publisher
Current Science Inc.
Published in
Current Gastroenterology Reports / Issue 6/2010
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-010-0145-9

Other articles of this Issue 6/2010

Current Gastroenterology Reports 6/2010 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine