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Current Diabetes Reports
Published in: Current Diabetes Reports 10/2018

Open Access 01-10-2018 | Genetics (AP Morris, Section Editor)

Genetics of Severe Obesity

Authors: Una Fairbrother, Elliot Kidd, Tanya Malagamuwa, Andrew Walley

Published in: Current Diabetes Reports | Issue 10/2018

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Abstract

Purpose of Review

This review aims to present current information on genes underlying severe obesity, with the main emphasis on the three genes LEP, LEPR and MC4R.

Recent Findings

There is a substantial amount of evidence that variants in at least ten different genes are the cause of severe monogenic obesity. The majority of these are involved in the leptin-melanocortin signalling pathway. Due to the frequency of some of the identified variants, it is clear that monogenic variants also make a significant contribution to common obesity.

Summary

The artificial distinction between rare monogenic obesity and common polygenic obesity is now obsolete with the identification of MC4R variants of strong effect in the general population.
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Metadata
Title
Genetics of Severe Obesity
Authors
Una Fairbrother
Elliot Kidd
Tanya Malagamuwa
Andrew Walley
Publication date
01-10-2018
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 10/2018
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-018-1053-x

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