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Current Diabetes Reports
Published in: Current Diabetes Reports 6/2017

01-06-2017 | Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors)

Simultaneous Pancreas and Kidney Transplantation—Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry

Authors: Angelika C. Gruessner, Mark R. Laftavi, Oleh Pankewycz, Rainer W. G. Gruessner

Published in: Current Diabetes Reports | Issue 6/2017

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Abstract

Purpose of Review

Pancreas transplantation remains the best long-term treatment option to achieve euglycemia and freedom from insulin in patients with labile diabetes mellitus. It is an approved procedure for type 1 (T1DM), but it is still considered controversial for type 2 diabetes mellitus (T2DM).

Recent Findings

This study analyzed all primary deceased donor pancreas transplants in patients with T2DM reported to IPTR/UNOS between 1995 and 2015. Characteristics, outcomes, and risk factors over time were determined using univariate and multivariate methods. The focus was on simultaneous pancreas/kidney (SPK) transplants, the most common pancreas transplant category. Patient, pancreas, and kidney graft survival rates increased significantly over time and reached 95.8, 83.3, and 91.1%, respectively, at 3 years posttransplant for transplants performed between 2009 and 2015.

Summary

SPK is a safe procedure with excellent pancreas and kidney graft outcome in patients with T2DM. The procedure restores euglycemia and freedom from insulin and dialysis. Based on our results, SPK should be offered to more uremic patients with labile T2DM.
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Metadata
Title
Simultaneous Pancreas and Kidney Transplantation—Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry
Authors
Angelika C. Gruessner
Mark R. Laftavi
Oleh Pankewycz
Rainer W. G. Gruessner
Publication date
01-06-2017
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 6/2017
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-017-0864-5

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Current Diabetes Reports 6/2017 Go to the issue

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Cell Therapy for Type 1 Diabetes: Current and Future Strategies

Economics and Policy in Diabetes (ES Huang and AA Baig, Section Editors)

The Role of the FDA and Regulatory Approval of New Devices for Diabetes Care

Lifestyle Management to Reduce Diabetes/Cardiovascular Risk (B Conway and H Keenan, Section Editors)

Interaction Between the Haptoglobin Genotype and Vitamin E on Cardiovascular Disease in Diabetes

Pathogenesis of Type 2 Diabetes and Insulin Resistance (RM Watanabe, Section Editor)

The Janus Head of Oxidative Stress in Metabolic Diseases and During Physical Exercise

Psychosocial Aspects (S Jaser, Section Editor)

Peer Coaching Interventions for Parents of Children with Type 1 Diabetes

Pediatric Type 2 and Monogenic Diabetes (PS Zeitler, Section Editor)

Vascular and Endothelial Function in Youth with Type 2 Diabetes Mellitus
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