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Published in: Current Bladder Dysfunction Reports 1/2015

01-03-2015 | Pelvic Pain (C Payne and J Potts, Section Editors)

Classic Interstitial Cystitis: Unrelated to BPS

Authors: Magnus Fall, Ralph Peeker

Published in: Current Bladder Dysfunction Reports | Issue 1/2015

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Abstract

When first recognized, more than one hundred years ago, the term interstitial cystitis (IC) was reserved for subjects with a special type of deep inflammation of the bladder wall. Later, the scope of IC widened, including all kinds of bladder pain syndromes (BPS), giving rise to a lot of confusion and difficulties in research as well as in clinical practice. Herein, recent progress in the understanding of the BPS/IC complex will be discussed, emphasizing the fact that the classic Hunner disease (BPS type 3C according to the European Society for the Study of Interstitial Cystitis (ESSIC) classification) is a well-defined condition that fulfills the requirements of the denomination interstitial cystitis. The paper will also discuss recent research on diagnostics, markers, genetics, and various types of remedies for classic IC. For the benefit of our patients, in BPS/IC, it is time for a final separation of the concepts BPS and IC. Classic IC is a well-defined entity with multiple unique characteristics, those characteristics having a potential for development of a specific rational, pharmacological, and surgical treatment algorithm if further investigated. BPS, on the other hand, seems to include a heterogenic composition of conditions calling for broad attempts to be more closely explored.
Literature
1.
go back to reference Skene AJC. Diseases of bladder and urethra in women. New York: Wm Wood; 1887. 167 p. Skene AJC. Diseases of bladder and urethra in women. New York: Wm Wood; 1887. 167 p.
2.
go back to reference Hunner GL. Elusive ulcer of the bladder: further notes on a rare type of bladder ulcer with report of 25 cases. Am J Obstet. 1918;78:374–95. Hunner GL. Elusive ulcer of the bladder: further notes on a rare type of bladder ulcer with report of 25 cases. Am J Obstet. 1918;78:374–95.
3.
go back to reference Hand JR. Interstitial cystitis: report of 223 cases (204 women and 19 men). J Urol. 1949;61:291–310.PubMed Hand JR. Interstitial cystitis: report of 223 cases (204 women and 19 men). J Urol. 1949;61:291–310.PubMed
4.
go back to reference Messing EM, Stamey TA. Interstitial cystitis: early diagnosis, pathology and treatment. Urology. 1978;12:381–92.PubMedCrossRef Messing EM, Stamey TA. Interstitial cystitis: early diagnosis, pathology and treatment. Urology. 1978;12:381–92.PubMedCrossRef
5.
go back to reference Fall M, Johansson SL, Aldenborg F. Chronic interstitial cystitis: a heterogeneous syndrome. J Urol. 1987;137:35–8.PubMed Fall M, Johansson SL, Aldenborg F. Chronic interstitial cystitis: a heterogeneous syndrome. J Urol. 1987;137:35–8.PubMed
6.
go back to reference Peeker R, Fall M. Towards a precise definition of interstitial cystitis: further evidence of differences in classic and nonulcer disease. J Urol. 2002;167:2470–2.PubMedCrossRef Peeker R, Fall M. Towards a precise definition of interstitial cystitis: further evidence of differences in classic and nonulcer disease. J Urol. 2002;167:2470–2.PubMedCrossRef
7.
go back to reference Wein A, Hanno P, Gillenwater J. In: Staskin, Hanno, Wein, Krane, editors. Interstitial cystitis. London: Springer; 1990. p. 3–15.CrossRef Wein A, Hanno P, Gillenwater J. In: Staskin, Hanno, Wein, Krane, editors. Interstitial cystitis. London: Springer; 1990. p. 3–15.CrossRef
8.
go back to reference Gillenwater JY, Wein AJ. Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases workshop on interstitial cystitis, National Institutes of Health, Bethesda, Maryland, August 28–29, 1987. J Urol. 1988;140(1):203–6 Gillenwater JY, Wein AJ. Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases workshop on interstitial cystitis, National Institutes of Health, Bethesda, Maryland, August 28–29, 1987. J Urol. 1988;140(1):203–6
9.
go back to reference Nordling J, Anjum F, Bade J, Bouchelouche K, Bouchelouche P, Cervigni M, et al. Primary evaluation of patients suspected of having interstitial cystitis (IC). Eur Urol. 2004;45(5):662–9.PubMedCrossRef Nordling J, Anjum F, Bade J, Bouchelouche K, Bouchelouche P, Cervigni M, et al. Primary evaluation of patients suspected of having interstitial cystitis (IC). Eur Urol. 2004;45(5):662–9.PubMedCrossRef
10.••
go back to reference van de Merwe JP, Nordling J, Bouchelouche P, Bouchelouche K, Cervigni M, Daha LK, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53(1):60–7. A fundamental step taken by the ESSIC to correctly describe and classify investigations of BPS/IC patients.PubMedCrossRef van de Merwe JP, Nordling J, Bouchelouche P, Bouchelouche K, Cervigni M, Daha LK, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53(1):60–7. A fundamental step taken by the ESSIC to correctly describe and classify investigations of BPS/IC patients.PubMedCrossRef
11.
go back to reference Oravisto KJ. Epidemiology of interstitial cystitis. Ann Chir Gynaecol Finn. 1975;64:75–7. Oravisto KJ. Epidemiology of interstitial cystitis. Ann Chir Gynaecol Finn. 1975;64:75–7.
12.
go back to reference Koziol JA. Epidemiology of interstitial cystitis. Urol Clin N Am. 1994;21(1):7–20. Koziol JA. Epidemiology of interstitial cystitis. Urol Clin N Am. 1994;21(1):7–20.
13.
go back to reference Held PJ, Hanno PM, Wein AJ, Pauly MV, Cann MA. Epidemiology of interstitial cystitis 2. In: Staskin, Hanno, Wein, Krane, editors. Interstitial cystitis. New York: Springer; 1990. p. 29–48.CrossRef Held PJ, Hanno PM, Wein AJ, Pauly MV, Cann MA. Epidemiology of interstitial cystitis 2. In: Staskin, Hanno, Wein, Krane, editors. Interstitial cystitis. New York: Springer; 1990. p. 29–48.CrossRef
14.
go back to reference Curhan GC, Speizer FE, Hunter DJ, Curhan SG, Stampfer MJ. Epidemiology of interstitial cystitis: a population based study. J Urol. 1999;161:549–52.PubMedCrossRef Curhan GC, Speizer FE, Hunter DJ, Curhan SG, Stampfer MJ. Epidemiology of interstitial cystitis: a population based study. J Urol. 1999;161:549–52.PubMedCrossRef
15.
go back to reference Berry S, Elliott M, Suttorp M, Bogart L, Stoto M, Eggers P, et al. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol. 2011;186(2):540–4.PubMedCentralPubMedCrossRef Berry S, Elliott M, Suttorp M, Bogart L, Stoto M, Eggers P, et al. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol. 2011;186(2):540–4.PubMedCentralPubMedCrossRef
16.
go back to reference Suskind A, Berry S, Ewing B, Elliott M, Suttorp M, Clemens J. The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome in men: results of the RAND Interstitial Cystitis Epidemiology male study. J Urol. 2013;189(1):141–5.PubMedCentralPubMedCrossRef Suskind A, Berry S, Ewing B, Elliott M, Suttorp M, Clemens J. The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome in men: results of the RAND Interstitial Cystitis Epidemiology male study. J Urol. 2013;189(1):141–5.PubMedCentralPubMedCrossRef
17.
go back to reference Leppilahti M, Sairanen J, Tammela TL, Aaltomaa S, Lehtoranta K, Auvinen A, et al. Prevalence of clinically confirmed interstitial cystitis in women: a population based study in Finland. J Urol. 2005;174(2):581–3.PubMedCrossRef Leppilahti M, Sairanen J, Tammela TL, Aaltomaa S, Lehtoranta K, Auvinen A, et al. Prevalence of clinically confirmed interstitial cystitis in women: a population based study in Finland. J Urol. 2005;174(2):581–3.PubMedCrossRef
18.
go back to reference Erickson D, Tomaszewski J, Kunselman A, Bentley C, Peters K, Rovner E, et al. Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis? J Urol. 2005;173(1):93–7.PubMedCrossRef Erickson D, Tomaszewski J, Kunselman A, Bentley C, Peters K, Rovner E, et al. Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis? J Urol. 2005;173(1):93–7.PubMedCrossRef
19.•
go back to reference Logadottir Y, Fall M, Kåbjörn-Gustafsson C, Peeker R. Clinical characteristics differ considerably between phenotypes of bladder pain syndrome/interstitial cystitis. Scand J Urol Nephrol. 2012;46(5):365–70. A paper demonstrating that a precise subtyping of BPS/IC can be achieved by adopting a rigorous investigation routine.PubMedCrossRef Logadottir Y, Fall M, Kåbjörn-Gustafsson C, Peeker R. Clinical characteristics differ considerably between phenotypes of bladder pain syndrome/interstitial cystitis. Scand J Urol Nephrol. 2012;46(5):365–70. A paper demonstrating that a precise subtyping of BPS/IC can be achieved by adopting a rigorous investigation routine.PubMedCrossRef
20.
go back to reference Meares Jr E. Interstitial cystitis—1987. Urology. 1987;29(4 Suppl):46–8.PubMed Meares Jr E. Interstitial cystitis—1987. Urology. 1987;29(4 Suppl):46–8.PubMed
21.
go back to reference Webster GD, Galloway N. Surgical treatment of interstitial cystitis. Indications, techniques, and results. Urology. 1987;29(4 Suppl):34–9.PubMed Webster GD, Galloway N. Surgical treatment of interstitial cystitis. Indications, techniques, and results. Urology. 1987;29(4 Suppl):34–9.PubMed
22.
go back to reference O’Leary M, Sant G, Fowler FJ, Whitmore K, Spolarich-Kroll J. The interstitial cystitis symptom index and problem index. Urology. 1997;49(5A Suppl):58–63.PubMedCrossRef O’Leary M, Sant G, Fowler FJ, Whitmore K, Spolarich-Kroll J. The interstitial cystitis symptom index and problem index. Urology. 1997;49(5A Suppl):58–63.PubMedCrossRef
23.
go back to reference Rais-Bahrami S, Friedlander J, Herati A, Sadek M, Ruzimovsky M, Moldwin R. Symptom profile variability of interstitial cystitis/painful bladder syndrome by age. BJU Int 2012;109 (9). Rais-Bahrami S, Friedlander J, Herati A, Sadek M, Ruzimovsky M, Moldwin R. Symptom profile variability of interstitial cystitis/painful bladder syndrome by age. BJU Int 2012;109 (9).
24.
go back to reference Lamale L, Lutgendorf S, Hoffman A, Kreder K. Symptoms and cystoscopic findings in patients with untreated interstitial cystitis. Urology. 2006;67(2):242–5.PubMedCrossRef Lamale L, Lutgendorf S, Hoffman A, Kreder K. Symptoms and cystoscopic findings in patients with untreated interstitial cystitis. Urology. 2006;67(2):242–5.PubMedCrossRef
25.
go back to reference Boudry G, Labat J, Normand L, Manunta A, Bensalah K, Rigaud J. Validation of voiding diary for stratification of bladder pain syndrome according to the presence/absence of cystoscopic abnormalities: a two-centre prospective study. BJU Int. 2013;112(2):E164–8.PubMedCrossRef Boudry G, Labat J, Normand L, Manunta A, Bensalah K, Rigaud J. Validation of voiding diary for stratification of bladder pain syndrome according to the presence/absence of cystoscopic abnormalities: a two-centre prospective study. BJU Int. 2013;112(2):E164–8.PubMedCrossRef
26.
go back to reference Stav K, Lang E, Fanus Z, Leibovici D. Autonomic response during bladder hydrodistention in patients with bladder pain syndrome. J Urol. 2012;188(1):117–21.PubMedCrossRef Stav K, Lang E, Fanus Z, Leibovici D. Autonomic response during bladder hydrodistention in patients with bladder pain syndrome. J Urol. 2012;188(1):117–21.PubMedCrossRef
27.
go back to reference Nickel J, Tripp D, Group. IICS. Clinical and psychological parameters associated with pain pattern phenotypes in women with interstitial cystitis/bladder pain syndrome (IC/BPS). J Urol. 2014 Aug 1. pii: S0022-5347(14)04148-2. Nickel J, Tripp D, Group. IICS. Clinical and psychological parameters associated with pain pattern phenotypes in women with interstitial cystitis/bladder pain syndrome (IC/BPS). J Urol. 2014 Aug 1. pii: S0022-5347(14)04148-2.
28.
go back to reference Killinger K, Boura J, Peters K. Pain in interstitial cystitis/bladder pain syndrome: do characteristics differ in ulcerative and non-ulcerative subtypes? Int Urogynecol J. 2013;24(8):1295–301.PubMedCrossRef Killinger K, Boura J, Peters K. Pain in interstitial cystitis/bladder pain syndrome: do characteristics differ in ulcerative and non-ulcerative subtypes? Int Urogynecol J. 2013;24(8):1295–301.PubMedCrossRef
29.•
go back to reference Ueda T, Nakagawa M, Okamura M, Tanoue H, Yoshida H, Yoshimura N. New cystoscopic diagnosis for interstitial cystitis/painful bladder syndrome using narrow-band imaging system. Int J Urol. 2008;15(12):1039–43. A promising technique to improve the diagnostic accuracy of cystoscopy.PubMedCrossRef Ueda T, Nakagawa M, Okamura M, Tanoue H, Yoshida H, Yoshimura N. New cystoscopic diagnosis for interstitial cystitis/painful bladder syndrome using narrow-band imaging system. Int J Urol. 2008;15(12):1039–43. A promising technique to improve the diagnostic accuracy of cystoscopy.PubMedCrossRef
30.
go back to reference Messing EM. The diagnosis of interstitial cystitis. Urology. 1987;29(4 Suppl):4–7.PubMed Messing EM. The diagnosis of interstitial cystitis. Urology. 1987;29(4 Suppl):4–7.PubMed
31.
go back to reference Furuya R, Masumori N, Furuya S, Oda T, Takahashi S, Takeuchi M. Glomerulation observed during transurethral resection of the prostate for patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia is a common finding but no predictor of clinical outcome. Urology. 2007;70(5):922–6.PubMedCrossRef Furuya R, Masumori N, Furuya S, Oda T, Takahashi S, Takeuchi M. Glomerulation observed during transurethral resection of the prostate for patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia is a common finding but no predictor of clinical outcome. Urology. 2007;70(5):922–6.PubMedCrossRef
32.
go back to reference Waxman J, Sulak P, Kuehl T. Cystoscopic findings consistent with interstitial cystitis in normal women undergoing tubal ligation. J Urol. 1998;160(5):1663–7.PubMedCrossRef Waxman J, Sulak P, Kuehl T. Cystoscopic findings consistent with interstitial cystitis in normal women undergoing tubal ligation. J Urol. 1998;160(5):1663–7.PubMedCrossRef
33.
go back to reference Richter B, Hesse U, Hansen A, Horn T, Mortensen S, Nordling J. Bladder pain syndrome/interstitial cystitis in a Danish population: a study using the 2008 criteria of the European Society for the Study of Interstitial Cystitis. BJU Int. 2010;105(5):660–7.PubMedCrossRef Richter B, Hesse U, Hansen A, Horn T, Mortensen S, Nordling J. Bladder pain syndrome/interstitial cystitis in a Danish population: a study using the 2008 criteria of the European Society for the Study of Interstitial Cystitis. BJU Int. 2010;105(5):660–7.PubMedCrossRef
34.••
go back to reference Johansson SL, Fall M. Clinical features and spectrum of light microscopic changes in interstitial cystitis. J Urol. 1990;143(6):1118–24. The first comprehensive outline on histopathological characteristics of classic IC.PubMed Johansson SL, Fall M. Clinical features and spectrum of light microscopic changes in interstitial cystitis. J Urol. 1990;143(6):1118–24. The first comprehensive outline on histopathological characteristics of classic IC.PubMed
35.
go back to reference Tissot W, Diokno A, Peters K. A referral center’s experience with transitional cell carcinoma misdiagnosed as interstitial cystitis. J Urol. 2004;172(2):478–80.PubMedCrossRef Tissot W, Diokno A, Peters K. A referral center’s experience with transitional cell carcinoma misdiagnosed as interstitial cystitis. J Urol. 2004;172(2):478–80.PubMedCrossRef
36.
go back to reference Erickson DR, Simon LJ, Belchis DA. Relationships between bladder inflammation and other clinical features in interstitial cystitis. Urology. 1994;44(5):655–9.PubMedCrossRef Erickson DR, Simon LJ, Belchis DA. Relationships between bladder inflammation and other clinical features in interstitial cystitis. Urology. 1994;44(5):655–9.PubMedCrossRef
37.
go back to reference Fall M, Johansson SL, Vahlne A. A clinicopathological and virological study of interstitial cystitis. J Urol. 1985;133(5):771–3.PubMed Fall M, Johansson SL, Vahlne A. A clinicopathological and virological study of interstitial cystitis. J Urol. 1985;133(5):771–3.PubMed
38.
go back to reference Aldenborg F, Fall M, Enerbäck L. Proliferation and transepithelial migration of mucosal mast cells in interstitial cystitis. Immunology. 1986;58:411–6.PubMedCentralPubMed Aldenborg F, Fall M, Enerbäck L. Proliferation and transepithelial migration of mucosal mast cells in interstitial cystitis. Immunology. 1986;58:411–6.PubMedCentralPubMed
39.
go back to reference Irani A-MA, Bradford TR, Kepley CL, Schechter NM, Schwartz LB. Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. J Histochem Cytochem. 1989;37:1509–15.PubMedCrossRef Irani A-MA, Bradford TR, Kepley CL, Schechter NM, Schwartz LB. Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. J Histochem Cytochem. 1989;37:1509–15.PubMedCrossRef
40.
go back to reference Peeker R, Fall M, Enerbäck L, Aldenborg F. Recruitment, distribution and phenotypes of mast cells in interstitial cystitis. J Urol. 2000;163:1009–15.PubMedCrossRef Peeker R, Fall M, Enerbäck L, Aldenborg F. Recruitment, distribution and phenotypes of mast cells in interstitial cystitis. J Urol. 2000;163:1009–15.PubMedCrossRef
41.
go back to reference Leiby B, Landis J, Propert K, Tomaszewski J, Group. ICDBS. Discovery of morphological subgroups that correlate with severity of symptoms in interstitial cystitis: a proposed biopsy classification system. J Urol. 2007;177(1):142–8.PubMedCrossRef Leiby B, Landis J, Propert K, Tomaszewski J, Group. ICDBS. Discovery of morphological subgroups that correlate with severity of symptoms in interstitial cystitis: a proposed biopsy classification system. J Urol. 2007;177(1):142–8.PubMedCrossRef
42.
go back to reference Kåbjörn-Gustafsson C, Peeker R. Biopsy retrieval, tissue handling, morphology and histopathological characteristics. In: Bladder pain syndrome. A guide for clinicians. Ed:s Nordling, Wyndaele, van de Merwe, Bouchelouche, Cervigni, Fall 2013; Springer Verlag: 231–9. Kåbjörn-Gustafsson C, Peeker R. Biopsy retrieval, tissue handling, morphology and histopathological characteristics. In: Bladder pain syndrome. A guide for clinicians. Ed:s Nordling, Wyndaele, van de Merwe, Bouchelouche, Cervigni, Fall 2013; Springer Verlag: 231–9.
43.
go back to reference Schwalenberg T, Stolzenburg J, Ho T, Mallock T, Hartenstein S, Alexander H, et al. Enhanced urothelial expression of human chorionic gonadotropin beta (hCGβ) in bladder pain syndrome/interstitial cystitis (BPS/IC). World J Urol. 2012;30(3):411–7.PubMedCrossRef Schwalenberg T, Stolzenburg J, Ho T, Mallock T, Hartenstein S, Alexander H, et al. Enhanced urothelial expression of human chorionic gonadotropin beta (hCGβ) in bladder pain syndrome/interstitial cystitis (BPS/IC). World J Urol. 2012;30(3):411–7.PubMedCrossRef
44.
go back to reference Larsen M, Mortensen S, Nordling J, Horn T. Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis. BJU Int. 2008;102:204–7.PubMedCrossRef Larsen M, Mortensen S, Nordling J, Horn T. Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis. BJU Int. 2008;102:204–7.PubMedCrossRef
45.
go back to reference Theoharides T, Kempuraj D, Tagen M, Conti P, Kalogeromitros D. Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev. 2007;217:65–78.PubMedCrossRef Theoharides T, Kempuraj D, Tagen M, Conti P, Kalogeromitros D. Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol Rev. 2007;217:65–78.PubMedCrossRef
46.
go back to reference Erickson D, Tomaszewski J, Kunselman A, Stetter C, Peters K, Rovner E, et al. Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/painful bladder syndrome. J Urol. 2008;179(5):1850–6.PubMedCentralPubMedCrossRef Erickson D, Tomaszewski J, Kunselman A, Stetter C, Peters K, Rovner E, et al. Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/painful bladder syndrome. J Urol. 2008;179(5):1850–6.PubMedCentralPubMedCrossRef
47.••
go back to reference Logadottir Y, Ehren I, Fall M, Wiklund NP, Peeker R. Intravesical nitric oxide production discriminates between classic and nonulcer interstitial cystitis. J Urol. 2004;171:1148–51. The first report presenting a marker (intraluminal evaporation of nitric oxide) that clearly can discriminate classic IC from non-Hunner BPS.PubMedCrossRef Logadottir Y, Ehren I, Fall M, Wiklund NP, Peeker R. Intravesical nitric oxide production discriminates between classic and nonulcer interstitial cystitis. J Urol. 2004;171:1148–51. The first report presenting a marker (intraluminal evaporation of nitric oxide) that clearly can discriminate classic IC from non-Hunner BPS.PubMedCrossRef
48.
go back to reference Koskela L, Thiel T, Ehren I, De Verdier P, Wiklund N. Localization and expression of inducible nitric oxide synthase in biopsies from patients with interstitial cystitis. J Urol. 2008;180:737–41.PubMedCrossRef Koskela L, Thiel T, Ehren I, De Verdier P, Wiklund N. Localization and expression of inducible nitric oxide synthase in biopsies from patients with interstitial cystitis. J Urol. 2008;180:737–41.PubMedCrossRef
49.
go back to reference Logadottir Y, Delbro D, Fall M, Gjertsson I, Jirholt P, Lindholm C, et al. Cytokine expression in patients with bladder pain syndrome/interstitial cystitis ESSIC type 3C. J Urol 2014; pii: S0022-5347(14)03518-6. Logadottir Y, Delbro D, Fall M, Gjertsson I, Jirholt P, Lindholm C, et al. Cytokine expression in patients with bladder pain syndrome/interstitial cystitis ESSIC type 3C. J Urol 2014; pii: S0022-5347(14)03518-6.
50.
go back to reference Logadottir Y, Hallsberg L, Fall M, Peeker R, Delbro D. Bladder pain syndrome/interstitial cystitis ESSIC type 3C: high expression of inducible nitric oxide synthase in inflammatory cells. Scand J Urol Nephrol. 2013;47(1):52–6.CrossRef Logadottir Y, Hallsberg L, Fall M, Peeker R, Delbro D. Bladder pain syndrome/interstitial cystitis ESSIC type 3C: high expression of inducible nitric oxide synthase in inflammatory cells. Scand J Urol Nephrol. 2013;47(1):52–6.CrossRef
52.
go back to reference Warren JW, Keay SK, Meyers D, Xu J. Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs. Urology. 2001;57(6 Suppl 1):22–5.PubMedCrossRef Warren JW, Keay SK, Meyers D, Xu J. Concordance of interstitial cystitis in monozygotic and dizygotic twin pairs. Urology. 2001;57(6 Suppl 1):22–5.PubMedCrossRef
53.
go back to reference Altman D, Lundholm C, Milsom I, Peeker R, Fall M, Iliadou AN, et al. The genetic and environmental contribution to the occurrence of bladder pain syndrome: an empirical approach in a nationwide population sample. Eur Urol. 2011;59(2):280–5.PubMedCrossRef Altman D, Lundholm C, Milsom I, Peeker R, Fall M, Iliadou AN, et al. The genetic and environmental contribution to the occurrence of bladder pain syndrome: an empirical approach in a nationwide population sample. Eur Urol. 2011;59(2):280–5.PubMedCrossRef
54.
go back to reference Tseng L, Chen I, Wang C, Lin Y, Lloyd L, Lee C. Genome-based expression profiling study of Hunner’s ulcer type interstitial cystitis: an array of 40-gene model. Int Urogynecol J. 2010;21(8):911–8.PubMedCrossRef Tseng L, Chen I, Wang C, Lin Y, Lloyd L, Lee C. Genome-based expression profiling study of Hunner’s ulcer type interstitial cystitis: an array of 40-gene model. Int Urogynecol J. 2010;21(8):911–8.PubMedCrossRef
55.
go back to reference Blalock E, Korrect G, Stromberg A, Erickson D. Gene expression analysis of urine sediment: evaluation for potential noninvasive markers of interstitial cystitis/bladder pain syndrome. J Urol. 2012;187(2):725–32.PubMedCrossRef Blalock E, Korrect G, Stromberg A, Erickson D. Gene expression analysis of urine sediment: evaluation for potential noninvasive markers of interstitial cystitis/bladder pain syndrome. J Urol. 2012;187(2):725–32.PubMedCrossRef
56.
go back to reference Fall M. Conservative management of chronic interstitial cystitis: transcutaneous electrical nerve stimulation and transurethral resection. J Urol. 1985;133:774–8.PubMed Fall M. Conservative management of chronic interstitial cystitis: transcutaneous electrical nerve stimulation and transurethral resection. J Urol. 1985;133:774–8.PubMed
57.
go back to reference Peeker R, Aldenborg F, Fall M. Complete transurethral resection of ulcers in classic interstitial cystitis. Int Urogynecol J. 2000;11:290–5.CrossRef Peeker R, Aldenborg F, Fall M. Complete transurethral resection of ulcers in classic interstitial cystitis. Int Urogynecol J. 2000;11:290–5.CrossRef
58.
go back to reference Shanberg AM, Malloy T. Treatment of interstitial cystitis with neodymium:YAG laser. Urology. 1987;29(4 Suppl):31–3.PubMed Shanberg AM, Malloy T. Treatment of interstitial cystitis with neodymium:YAG laser. Urology. 1987;29(4 Suppl):31–3.PubMed
59.
go back to reference Hillelsohn J, Rais-Bahrami S, Friedlander J, Okhunov Z, Kashan M, Rosen L, et al. Fulguration for Hunner ulcers: long-term clinical outcomes. J Urol. 2012;188(6):2238–41.PubMedCrossRef Hillelsohn J, Rais-Bahrami S, Friedlander J, Okhunov Z, Kashan M, Rosen L, et al. Fulguration for Hunner ulcers: long-term clinical outcomes. J Urol. 2012;188(6):2238–41.PubMedCrossRef
60.
go back to reference Cox M, Klutke J, Klutke C. Assessment of patient outcomes following submucosal injection of triamcinolone for treatment of Hunner’s ulcer subtype interstitial cystitis. Can J Urol. 2009;16(2):4536–40.PubMed Cox M, Klutke J, Klutke C. Assessment of patient outcomes following submucosal injection of triamcinolone for treatment of Hunner’s ulcer subtype interstitial cystitis. Can J Urol. 2009;16(2):4536–40.PubMed
61.
go back to reference Sairanen J, Tammela TL, Leppilahti M, Multanen M, Paananen I, Lehtoranta K, et al. Cyclosporine A and pentosan polysulfate sodium for the treatment of interstitial cystitis: a randomized comparative study. J Urol. 2005;174(6):2235–8.PubMedCrossRef Sairanen J, Tammela TL, Leppilahti M, Multanen M, Paananen I, Lehtoranta K, et al. Cyclosporine A and pentosan polysulfate sodium for the treatment of interstitial cystitis: a randomized comparative study. J Urol. 2005;174(6):2235–8.PubMedCrossRef
62.
go back to reference Forrest J, Payne C, Erickson D. Cyclosporine A for refractory interstitial cystitis/bladder pain syndrome: experience of 3 tertiary centers. J Urol. 2012;188(4):1186–91.PubMedCrossRef Forrest J, Payne C, Erickson D. Cyclosporine A for refractory interstitial cystitis/bladder pain syndrome: experience of 3 tertiary centers. J Urol. 2012;188(4):1186–91.PubMedCrossRef
63.
go back to reference Ehrén I, Hallén Grufman K, Vrba M, Sundelin R, Lafolie P. Nitric oxide as a marker for evaluation of treatment effect of cyclosporine A in patients with bladder pain syndrome/interstitial cystitis type 3C. Scand J Urol. 2013;47(6):503–8.PubMedCrossRef Ehrén I, Hallén Grufman K, Vrba M, Sundelin R, Lafolie P. Nitric oxide as a marker for evaluation of treatment effect of cyclosporine A in patients with bladder pain syndrome/interstitial cystitis type 3C. Scand J Urol. 2013;47(6):503–8.PubMedCrossRef
64.
go back to reference Fall M, Lindstrom S. Transcutaneous electrical nerve stimulation in classic and nonulcer interstitial cystitis. Urol Clin N Am. 1994;21(1):131–9. Fall M, Lindstrom S. Transcutaneous electrical nerve stimulation in classic and nonulcer interstitial cystitis. Urol Clin N Am. 1994;21(1):131–9.
65.
go back to reference Fritjofsson A, Fall M, Juhlin R, Persson BE, Ruutu M. Treatment of ulcer and nonulcer interstitial cystitis with sodium pentosanpolysulfate: a multicenter trial. J Urol. 1987;138(3):508–12.PubMed Fritjofsson A, Fall M, Juhlin R, Persson BE, Ruutu M. Treatment of ulcer and nonulcer interstitial cystitis with sodium pentosanpolysulfate: a multicenter trial. J Urol. 1987;138(3):508–12.PubMed
66.
go back to reference Peeker R, Aldenborg F, Fall M. The treatment of interstitial cystitis with supratrigonal cystectomy and ileocystoplasty: difference in outcome between classic and nonulcer disease. J Urol. 1998;159(5):1479–82.PubMedCrossRef Peeker R, Aldenborg F, Fall M. The treatment of interstitial cystitis with supratrigonal cystectomy and ileocystoplasty: difference in outcome between classic and nonulcer disease. J Urol. 1998;159(5):1479–82.PubMedCrossRef
67.
go back to reference Rössberger J, Fall M, Jonsson O, Peeker R. Long-term results of reconstructive surgery in patients with bladder pain syndrome/interstitial cystitis: subtyping is imperative. Urology. 2007;70(4):638–42.PubMedCrossRef Rössberger J, Fall M, Jonsson O, Peeker R. Long-term results of reconstructive surgery in patients with bladder pain syndrome/interstitial cystitis: subtyping is imperative. Urology. 2007;70(4):638–42.PubMedCrossRef
68.
go back to reference Peters K, Jaeger C, Killinger K, Rosenberg B, Boura J. Cystectomy for ulcerative interstitial cystitis: sequelae and patients’ perceptions of improvement. Urology. 2013;82(4):829–33.PubMedCrossRef Peters K, Jaeger C, Killinger K, Rosenberg B, Boura J. Cystectomy for ulcerative interstitial cystitis: sequelae and patients’ perceptions of improvement. Urology. 2013;82(4):829–33.PubMedCrossRef
69.
go back to reference Pinto R, Lopes T, Costa D, Barros S, Silva J, Silva C, et al. Ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis do not differ in symptom intensity or response to onabotulinum toxin A. Urology. 2014;83(5):1030–4.PubMedCrossRef Pinto R, Lopes T, Costa D, Barros S, Silva J, Silva C, et al. Ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis do not differ in symptom intensity or response to onabotulinum toxin A. Urology. 2014;83(5):1030–4.PubMedCrossRef
70.
go back to reference Fall M, Logadottir Y, Peeker R. Interstitial cystitis is bladder pain syndrome with Hunner’s lesion. Int J Urol. 2014;21 Suppl 1:79–82.PubMedCrossRef Fall M, Logadottir Y, Peeker R. Interstitial cystitis is bladder pain syndrome with Hunner’s lesion. Int J Urol. 2014;21 Suppl 1:79–82.PubMedCrossRef
Metadata
Title
Classic Interstitial Cystitis: Unrelated to BPS
Authors
Magnus Fall
Ralph Peeker
Publication date
01-03-2015
Publisher
Springer US
Published in
Current Bladder Dysfunction Reports / Issue 1/2015
Print ISSN: 1931-7212
Electronic ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-014-0273-4

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