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Current Allergy and Asthma Reports

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31-01-2024 | Mastocytosis

Cognitive Impairment and Depression in Mastocytosis: A Synthesis of the Literature

Authors: Jennifer Nicoloro-SantaBarbara, Marzieh Majd, Katherine E. Burdick, Victoria Dixon, Matthew P. Giannetti

Published in: Current Allergy and Asthma Reports | Issue 2/2024

Abstract

Purpose of Review

Symptoms of depression and cognitive dysfunction are commonly reported in mastocytosis. The aims of this review paper are to summarize the current literature on cognitive dysfunction and depressive symptoms, elucidate some of the mechanistic pathways underlying depressive symptoms in mastocytosis, identify gaps in the literature, and offer guidance for future research in this area.

Recent Findings

The study of cognition and depression in mastocytosis is in its infancy and the methodological flaws of the current literature limit interpretability. There is preliminary evidence that some individuals with mastocytosis might experience mild deficits in memory. On average, depression symptom scores fell within the mild to moderate or sub-syndromal range. Regrettably, only one study utilized a standardized diagnostic instrument to assess major depressive disorder. The authors’ tendency to inaccurately equate depressive symptoms with a diagnosis of major depressive disorder presents a notable issue.

Summary

The prevalence of cognitive deficits and depression appears to be similar to other chronic illnesses. Future work needs to better characterize cognition and characterize “depression” in this population.

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Title: Cognitive Impairment and Depression in Mastocytosis: A Synthesis of the Literature
Authors: Jennifer Nicoloro-SantaBarbara
Marzieh Majd
Katherine E. Burdick
Victoria Dixon
Matthew P. Giannetti
Publication date: 31-01-2024
Publisher: Springer US
Keywords: Mastocytosis
Mood Disorders
Affective Disorder
Published in: Current Allergy and Asthma Reports / Issue 2/2024
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-024-01127-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Cognitive Impairment and Depression in Mastocytosis: A Synthesis of the Literature

Abstract

Purpose of Review

Recent Findings

Summary

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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