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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 10/2015

01-10-2015 | Basic and Applied Science (M Frieri and PJ Bryce, Section Editors)

Allergic Inflammation in Aspergillus fumigatus-Induced Fungal Asthma

Authors: Sumit Ghosh, Scott A. Hoselton, Jane M. Schuh

Published in: Current Allergy and Asthma Reports | Issue 10/2015

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Abstract

Although fungi are pervasive in many environments, few cause disease in humans. Of these, Aspergillus fumigatus is particularly well suited to be a pathogen of the human lung. Its physical and biological characteristics combine to provide an organism that can cause tremendous morbidity and high mortality if left unchecked. Luckily, that is rarely the case. However, repeated exposure to inhaled A. fumigatus spores often results in an immune response that carries significant immunopathology, exacerbating asthma and changing the structure of the lung with chronic impacts to pulmonary function. This review focuses on the current understanding of the mechanisms that are associated with fungal exposure, sensitization, and infection in asthmatics, as well as the function of various inflammatory cells associated with severe asthma with fungal sensitization.
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Metadata
Title
Allergic Inflammation in Aspergillus fumigatus-Induced Fungal Asthma
Authors
Sumit Ghosh
Scott A. Hoselton
Jane M. Schuh
Publication date
01-10-2015
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 10/2015
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-015-0561-x