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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 6/2015

01-06-2015 | Anaphylaxis and Drug Allergy (DA Khan and M Castells, Section Editors)

Utility of Component-Resolved Diagnostics in Food Allergy

Authors: Karen S. Tuano, Carla M. Davis

Published in: Current Allergy and Asthma Reports | Issue 6/2015

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Abstract

Allergen component-resolved diagnostic testing (CRD) is a new methodology in clinical food allergy diagnosis, improving the ability to identify specific clinical phenotypes. Instead of relying on the crude allergen extracts used in standard allergy diagnostics, CRD utilizes purified or recombinant allergens for identification of specific molecules causing sensitization or allergy. This method is able to determine risk of the severity of allergic reactions in specific cases, like soy, peanut, and hazelnut allergy. The severity of allergic reaction can be predicted in peanut allergy with Ara h 2, and clinically relevant disease in pollen-allergic patients can be identified. However, age and geographic differences affect CRD results and it should always be utilized in the context of a clinical history. In the future, clinical phenotypes may be differentiated with larger prospective studies utilizing food challenges.
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Metadata
Title
Utility of Component-Resolved Diagnostics in Food Allergy
Authors
Karen S. Tuano
Carla M. Davis
Publication date
01-06-2015
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 6/2015
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-015-0534-0

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