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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 2/2015

01-02-2015 | ALLERGENS (RK BUSH AND JA WOODFOLK, SECTION EDITORS)

Rhinovirus and Asthma: a Storied History of Incompatibility

Authors: Catherine Hammond, Megan Kurten, Joshua L. Kennedy

Published in: Current Allergy and Asthma Reports | Issue 2/2015

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Abstract

The human rhinovirus (HRV) is commonly associated with loss of asthma symptom control requiring escalation of care and emergency room visits in many patients. While the association is clear, the mechanisms behind HRV-induced asthma exacerbations remain uncertain. Immune dysregulation via aberrant immune responses, both deficient and exaggerated, have been proposed as mechanisms for HRV-induced exacerbations of asthma. Epithelium-derived innate immune cytokines that bias Th2 responses, including interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP), have also been implicated as a means to bridge allergic conditions with asthma exacerbations. In this review, we discuss the literature supporting these positions. We also discuss new and emerging biotherapeutics that may target virus-induced exacerbations of asthma.
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Metadata
Title
Rhinovirus and Asthma: a Storied History of Incompatibility
Authors
Catherine Hammond
Megan Kurten
Joshua L. Kennedy
Publication date
01-02-2015
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 2/2015
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-014-0502-0

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