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01-02-2013 | BASIC AND APPLIED SCIENCE (M FRIERI, SECTION EDITOR)

Vascular Endothelial Growth Factor as a Key Inducer of Angiogenesis in the Asthmatic Airways

Authors: Norbert Meyer, Cezmi A. Akdis

Published in: Current Allergy and Asthma Reports | Issue 1/2013

Abstract

Asthma is a chronic inflammatory disease of the airways characterized by structural airway changes, which are known as airway remodeling, including smooth muscle hypertrophy, goblet cell hyperplasia, subepithelial fibrosis, and angiogenesis. Vascular remodeling in asthmatic lungs results from increased angiogenesis, which is mainly mediated by vascular endothelial growth factor (VEGF). VEGF is a key regulator of blood vessel growth in the airways of asthma patients by promoting proliferation and differentiation of endothelial cells and inducing vascular leakage and permeability. In addition, VEGF induces allergic inflammation, enhances allergic sensitization, and has a role in Th2 type inflammatory responses. Specific inhibitors of VEGF and blockers of its receptors might be useful to control chronic airway inflammation and vascular remodeling, and might be a new therapeutic approach for chronic inflammatory airway disease like asthma.

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Title: Vascular Endothelial Growth Factor as a Key Inducer of Angiogenesis in the Asthmatic Airways
Authors: Norbert Meyer
Cezmi A. Akdis
Publication date: 01-02-2013
Publisher: Current Science Inc.
Published in: Current Allergy and Asthma Reports / Issue 1/2013
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-012-0317-9

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Vascular Endothelial Growth Factor as a Key Inducer of Angiogenesis in the Asthmatic Airways

Abstract

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Abstract

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