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Published in: Current Allergy and Asthma Reports 6/2012

01-12-2012 | Pediatric Allergy and Immunology (JM Portnoy and CE Ciaccio, Section Editors)

Current Strategies in Treating Severe Contact Dermatitis in Pediatric Patients

Authors: Luz S. Fonacier, Marcella R. Aquino, Tania Mucci

Published in: Current Allergy and Asthma Reports | Issue 6/2012

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Abstract

Allergic contact dermatitis in children is underdiagnosed and undertreated, and its incidence is increasing. Appropriate history taking and the suspicion for allergic contact dermatitis is essential, and patch testing remains the gold standard in diagnosis. Avoidance of the offending allergen, once identified, is the first goal of treatment. Medical therapies include topical corticosteroid and topical immunomodulators. In severe cases, oral corticosteroids or immunomodulators are utilized, although prospective randomized trials for the treatment of this disease in children are lacking. A PubMed literature search was performed to identify publications on allergic contact dermatitis in the pediatric population with the keywords: dermatitis, children, allergic contact dermatitis, pediatrics, contact hypersensitivity, contact allergy, treatment, and management. This review will address the major principles behind the diagnosis and management of this disease in the pediatric population, and highlight useful strategies that may result in improved treatment of this condition.
Literature
1.
go back to reference Bickers DR, Lim HW, Margolis D, et al. The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol. 2006;55(3):490–500.PubMedCrossRef Bickers DR, Lim HW, Margolis D, et al. The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol. 2006;55(3):490–500.PubMedCrossRef
2.
go back to reference Militello G, Jacob SE, Crawford GH. Allergic contact dermatitis in children. Curr Opin Pediatr. 2006;18(4):385–90.PubMedCrossRef Militello G, Jacob SE, Crawford GH. Allergic contact dermatitis in children. Curr Opin Pediatr. 2006;18(4):385–90.PubMedCrossRef
3.
go back to reference Jacob SE, Brod B, Crawford GH. Clinically relevant patch test reactions in children–a United States based study. Pediatr Dermatol. 2008;25(5):520–7.PubMedCrossRef Jacob SE, Brod B, Crawford GH. Clinically relevant patch test reactions in children–a United States based study. Pediatr Dermatol. 2008;25(5):520–7.PubMedCrossRef
4.
go back to reference Sharma VK, Asati DP. Pediatric contact dermatitis. Indian J Dermatol Venereol Leprol. 2010;76(5):514–20.PubMedCrossRef Sharma VK, Asati DP. Pediatric contact dermatitis. Indian J Dermatol Venereol Leprol. 2010;76(5):514–20.PubMedCrossRef
5.
go back to reference Kutting B, Brehler R, Traupe H. Allergic contact dermatitis in children: strategies of prevention and risk management. Eur J Dermatol. 2004;14(2):80–5.PubMed Kutting B, Brehler R, Traupe H. Allergic contact dermatitis in children: strategies of prevention and risk management. Eur J Dermatol. 2004;14(2):80–5.PubMed
6.
go back to reference Giordano-Labadie F, Rance F, Pellegrin F, Bazex J, Dutau G, Schwarze HP. Frequency of contact allergy in children with atopic dermatitis: results of a prospective study of 137 cases. Contact Dermatitis. 1999;40(4):192–5.PubMedCrossRef Giordano-Labadie F, Rance F, Pellegrin F, Bazex J, Dutau G, Schwarze HP. Frequency of contact allergy in children with atopic dermatitis: results of a prospective study of 137 cases. Contact Dermatitis. 1999;40(4):192–5.PubMedCrossRef
7.
go back to reference • Herro EM, Matiz C, Sullivan K, Hamann C, Jacob SE. Frequency of contact allergens in pediatric patients with atopic dermatitis. J Clin Aesthet Dermatol. 2011;4(11):39-41. Retrospective chart review, suggesting that patch testing is indicated in children with moderate-to severe atopic dermatitis. PubMed • Herro EM, Matiz C, Sullivan K, Hamann C, Jacob SE. Frequency of contact allergens in pediatric patients with atopic dermatitis. J Clin Aesthet Dermatol. 2011;4(11):39-41. Retrospective chart review, suggesting that patch testing is indicated in children with moderate-to severe atopic dermatitis. PubMed
8.
go back to reference Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE. Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis. Br J Dermatol. 2001;144(3):523–32.PubMedCrossRef Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE. Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis. Br J Dermatol. 2001;144(3):523–32.PubMedCrossRef
9.
go back to reference Goebeler M, Trautmann A, Voss A, Brocker EV, Toksoy A, Gillitzer R. Differential and sequential expression of multiple chemokines during elicitation of allergic contact hypersensitivity. Am J Pathol. 2001;158(2):431–40.PubMedCrossRef Goebeler M, Trautmann A, Voss A, Brocker EV, Toksoy A, Gillitzer R. Differential and sequential expression of multiple chemokines during elicitation of allergic contact hypersensitivity. Am J Pathol. 2001;158(2):431–40.PubMedCrossRef
10.
go back to reference Saint-Mezard P, Berard F, Dubois B, Kaiserlian D, Nicolas JF. The role of CD4+ and CD8+ T cells in contact hypersensitivity and allergic contact dermatitis. Eur J Dermatol. 2004;14(3):131–8.PubMed Saint-Mezard P, Berard F, Dubois B, Kaiserlian D, Nicolas JF. The role of CD4+ and CD8+ T cells in contact hypersensitivity and allergic contact dermatitis. Eur J Dermatol. 2004;14(3):131–8.PubMed
11.
go back to reference Belhadjali H, Mohamed M, Youssef M, Mandhouj S, Chakroun M, Zili J. Contact sensitization in atopic dermatitis: results of a prospective study of 89 cases in Tunisia. Contact Dermatitis. 2008;58(3):188–9.PubMedCrossRef Belhadjali H, Mohamed M, Youssef M, Mandhouj S, Chakroun M, Zili J. Contact sensitization in atopic dermatitis: results of a prospective study of 89 cases in Tunisia. Contact Dermatitis. 2008;58(3):188–9.PubMedCrossRef
12.
go back to reference Astner S, Gonzalez E, Cheung AC, et al. Non-invasive evaluation of the kinetics of allergic and irritant contact dermatitis. J Invest Dermatol. 2005;124(2):351–9.PubMedCrossRef Astner S, Gonzalez E, Cheung AC, et al. Non-invasive evaluation of the kinetics of allergic and irritant contact dermatitis. J Invest Dermatol. 2005;124(2):351–9.PubMedCrossRef
13.
go back to reference Brasch J, Burgard J, Sterry W. Common pathogenetic pathways in allergic and irritant contact dermatitis. J Invest Dermatol. 1992;98(2):166–70.PubMedCrossRef Brasch J, Burgard J, Sterry W. Common pathogenetic pathways in allergic and irritant contact dermatitis. J Invest Dermatol. 1992;98(2):166–70.PubMedCrossRef
14.
go back to reference • Belloni Fortina A, Romano I, Peserico A, Eichenfield LF. Contact sensitization in very young children. J Am Acad Dermatol. 2011;65(4):772-779. 321 children aged 3-36 months underwent patch testing for suspected allergic contact dermatitis. A high prevalence of contact sensitization was found in toddlers younger than 3 years of age. Allergic contact dermatitis should be considered in this population. PubMedCrossRef • Belloni Fortina A, Romano I, Peserico A, Eichenfield LF. Contact sensitization in very young children. J Am Acad Dermatol. 2011;65(4):772-779. 321 children aged 3-36 months underwent patch testing for suspected allergic contact dermatitis. A high prevalence of contact sensitization was found in toddlers younger than 3 years of age. Allergic contact dermatitis should be considered in this population. PubMedCrossRef
15.
go back to reference Litvinov IV, Sugathan P, Cohen BA. Recognizing and treating toilet-seat contact dermatitis in children. Pediatrics. 2010;125(2):e419–22.PubMedCrossRef Litvinov IV, Sugathan P, Cohen BA. Recognizing and treating toilet-seat contact dermatitis in children. Pediatrics. 2010;125(2):e419–22.PubMedCrossRef
16.
go back to reference Matiz C, Jacob SE. Systemic contact dermatitis in children: how an avoidance diet can make a difference. Pediatr Dermatol. 2011;28(4):368–74.PubMedCrossRef Matiz C, Jacob SE. Systemic contact dermatitis in children: how an avoidance diet can make a difference. Pediatr Dermatol. 2011;28(4):368–74.PubMedCrossRef
17.
go back to reference Seidenari S, Giusti F, Pepe P, Mantovani L. Contact sensitization in 1094 children undergoing patch testing over a 7-year period. Pediatr Dermatol. 2005;22(1):1–5.PubMedCrossRef Seidenari S, Giusti F, Pepe P, Mantovani L. Contact sensitization in 1094 children undergoing patch testing over a 7-year period. Pediatr Dermatol. 2005;22(1):1–5.PubMedCrossRef
18.
go back to reference Champion RH, Rook A, Wilkinson DS, Ebling FJG. Rook/Wilkinson/Ebling textbook of dermatology. 6th ed. Oxford Malden, MA: Blackwell Science; 1998. Champion RH, Rook A, Wilkinson DS, Ebling FJG. Rook/Wilkinson/Ebling textbook of dermatology. 6th ed. Oxford Malden, MA: Blackwell Science; 1998.
19.
go back to reference Contact dermatitis: a practice parameter. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2006;97(3 Suppl 2):S1-38. Contact dermatitis: a practice parameter. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2006;97(3 Suppl 2):S1-38.
20.
go back to reference • Bonitsis NG, Tatsioni A, Bassioukas K, Ioannidis JP. Allergens responsible for allergic contact dermatitis among children: a systematic review and meta-analysis. Contact Dermatitis. May 2011;64(5):245-257. Meta-analysis to evaluate the proportion of positive reactions for allergens tested in children, offering guidance on relevant contact allergens in the pediatric population. PubMedCrossRef • Bonitsis NG, Tatsioni A, Bassioukas K, Ioannidis JP. Allergens responsible for allergic contact dermatitis among children: a systematic review and meta-analysis. Contact Dermatitis. May 2011;64(5):245-257. Meta-analysis to evaluate the proportion of positive reactions for allergens tested in children, offering guidance on relevant contact allergens in the pediatric population. PubMedCrossRef
21.
go back to reference Heine G, Schnuch A, Uter W, Worm M. Frequency of contact allergy in German children and adolescents patch tested between 1995 and 2002: results from the Information Network of Departments of Dermatology and the German Contact Dermatitis Research Group. Contact Dermatitis. 2004;51(3):111–7.PubMedCrossRef Heine G, Schnuch A, Uter W, Worm M. Frequency of contact allergy in German children and adolescents patch tested between 1995 and 2002: results from the Information Network of Departments of Dermatology and the German Contact Dermatitis Research Group. Contact Dermatitis. 2004;51(3):111–7.PubMedCrossRef
22.
go back to reference Rycroft RJG. Textbook of contact dermatitis. 3rd ed. Berlin New York: Springer; 2001. Rycroft RJG. Textbook of contact dermatitis. 3rd ed. Berlin New York: Springer; 2001.
23.
go back to reference Fernandez Vozmediano JM, Armario Hita JC. Allergic contact dermatitis in children. J Eur Acad Dermatol Venereol. 2005;19(1):42–6.PubMedCrossRef Fernandez Vozmediano JM, Armario Hita JC. Allergic contact dermatitis in children. J Eur Acad Dermatol Venereol. 2005;19(1):42–6.PubMedCrossRef
24.
go back to reference Larsson-Stymne B, Widstrom L. Ear piercing–a cause of nickel allergy in schoolgirls? Contact Dermatitis. 1985;13(5):289–93.PubMedCrossRef Larsson-Stymne B, Widstrom L. Ear piercing–a cause of nickel allergy in schoolgirls? Contact Dermatitis. 1985;13(5):289–93.PubMedCrossRef
25.
go back to reference Rystedt I, Fischer T. Relationship between nickel and cobalt sensitization in hard metal workers. Contact Dermatitis. 1983;9(3):195–200.PubMedCrossRef Rystedt I, Fischer T. Relationship between nickel and cobalt sensitization in hard metal workers. Contact Dermatitis. 1983;9(3):195–200.PubMedCrossRef
26.
go back to reference Dotterud LK, Falk ES. Metal allergy in north Norwegian schoolchildren and its relationship with ear piercing and atopy. Contact Dermatitis. 1994;31(5):308–13.PubMedCrossRef Dotterud LK, Falk ES. Metal allergy in north Norwegian schoolchildren and its relationship with ear piercing and atopy. Contact Dermatitis. 1994;31(5):308–13.PubMedCrossRef
27.
28.
go back to reference Veien NK, Hattel T, Laurberg G. Low nickel diet: an open, prospective trial. J Am Acad Dermatol. 1993;29(6):1002–7.PubMedCrossRef Veien NK, Hattel T, Laurberg G. Low nickel diet: an open, prospective trial. J Am Acad Dermatol. 1993;29(6):1002–7.PubMedCrossRef
29.
go back to reference Antico A, Soana R. Chronic allergic-like dermatopathies in nickel-sensitive patients. Results of dietary restrictions and challenge with nickel salts. Allergy Asthma Proc. 1999;20(4):235–42.PubMedCrossRef Antico A, Soana R. Chronic allergic-like dermatopathies in nickel-sensitive patients. Results of dietary restrictions and challenge with nickel salts. Allergy Asthma Proc. 1999;20(4):235–42.PubMedCrossRef
30.
go back to reference Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007;73(5):307–12.PubMedCrossRef Sharma AD. Relationship between nickel allergy and diet. Indian J Dermatol Venereol Leprol. 2007;73(5):307–12.PubMedCrossRef
31.
32.
go back to reference van’t Veen AJ. Vaccines without thiomersal: why so necessary, why so long coming? Drugs. 2001;61(5):565–72.PubMedCrossRef van’t Veen AJ. Vaccines without thiomersal: why so necessary, why so long coming? Drugs. 2001;61(5):565–72.PubMedCrossRef
33.
go back to reference Roul S, Ducombs G, Taieb A. Usefulness of the European standard series for patch testing in children. A 3-year single-centre study of 337 patients. Contact Dermatitis. 1999;40(5):232–5.PubMedCrossRef Roul S, Ducombs G, Taieb A. Usefulness of the European standard series for patch testing in children. A 3-year single-centre study of 337 patients. Contact Dermatitis. 1999;40(5):232–5.PubMedCrossRef
34.
go back to reference Trattner A, David M. Patch testing with fine fragrances: comparison with fragrance mix, balsam of Peru and a fragrance series. Contact Dermatitis. 2004;49(6):287–9.PubMedCrossRef Trattner A, David M. Patch testing with fine fragrances: comparison with fragrance mix, balsam of Peru and a fragrance series. Contact Dermatitis. 2004;49(6):287–9.PubMedCrossRef
35.
go back to reference Larsen W, Nakayama H, Lindberg M, et al. Fragrance contact dermatitis: a worldwide multicenter investigation (Part I). Am J Contact Dermat. 1996;7(2):77–83.PubMedCrossRef Larsen W, Nakayama H, Lindberg M, et al. Fragrance contact dermatitis: a worldwide multicenter investigation (Part I). Am J Contact Dermat. 1996;7(2):77–83.PubMedCrossRef
36.
go back to reference Zug KA, Warshaw EM, Fowler Jr JF, et al. Patch-test results of the North American Contact Dermatitis Group 2005-2006. Dermatitis. 2009;20(3):149–60.PubMed Zug KA, Warshaw EM, Fowler Jr JF, et al. Patch-test results of the North American Contact Dermatitis Group 2005-2006. Dermatitis. 2009;20(3):149–60.PubMed
37.
go back to reference Hjorth N. Eczematous allergy to balsams, allied perfumes and flavouring agents, with special reference to balsam of Peru. Acta Derm Venereol Suppl (Stockh). 1961;41 Suppl 46:1–216. Hjorth N. Eczematous allergy to balsams, allied perfumes and flavouring agents, with special reference to balsam of Peru. Acta Derm Venereol Suppl (Stockh). 1961;41 Suppl 46:1–216.
38.
go back to reference Bedello PG, Goitre M, Cane D. Contact dermatitis and flare from food flavouring agents. Contact Dermatitis. 1982;8(2):143–4.PubMedCrossRef Bedello PG, Goitre M, Cane D. Contact dermatitis and flare from food flavouring agents. Contact Dermatitis. 1982;8(2):143–4.PubMedCrossRef
39.
go back to reference Salam TN, Fowler Jr JF. Balsam-related systemic contact dermatitis. J Am Acad Dermatol. 2001;45(3):377–81.PubMedCrossRef Salam TN, Fowler Jr JF. Balsam-related systemic contact dermatitis. J Am Acad Dermatol. 2001;45(3):377–81.PubMedCrossRef
40.
go back to reference Veien NK, Hattel T, Justesen O, Norholm A. Reduction of intake of balsams in patients sensitive to balsam of Peru. Contact Dermatitis. 1985;12(5):270–3.PubMedCrossRef Veien NK, Hattel T, Justesen O, Norholm A. Reduction of intake of balsams in patients sensitive to balsam of Peru. Contact Dermatitis. 1985;12(5):270–3.PubMedCrossRef
41.
go back to reference Veien NK, Hattel T, Justesen O, Norholm N. Oral challenge with balsam of Peru. Contact Dermatitis. 1985;12(2):104–7.PubMedCrossRef Veien NK, Hattel T, Justesen O, Norholm N. Oral challenge with balsam of Peru. Contact Dermatitis. 1985;12(2):104–7.PubMedCrossRef
42.
go back to reference Fisher AA, Rietschel RL, Fowler JF. Fisher’s contact dermatitis. 6th ed. Hamilton: BC Decker Inc.; 2008. Fisher AA, Rietschel RL, Fowler JF. Fisher’s contact dermatitis. 6th ed. Hamilton: BC Decker Inc.; 2008.
43.
go back to reference Bjarnason B, Flosadottir E. Patch testing with neomycin sulfate. Contact Dermatitis. 2000;43(5):295–302.PubMedCrossRef Bjarnason B, Flosadottir E. Patch testing with neomycin sulfate. Contact Dermatitis. 2000;43(5):295–302.PubMedCrossRef
44.
go back to reference De U, Pal DK. Seventy cases of non-tubercular psoas abscess at a rural referral centre in South Bengal. Tropical doctor. 2006;36(1):53–4.PubMedCrossRef De U, Pal DK. Seventy cases of non-tubercular psoas abscess at a rural referral centre in South Bengal. Tropical doctor. 2006;36(1):53–4.PubMedCrossRef
45.
go back to reference Kwittken PL, Rosen S, Sweinberg SK. MMR vaccine and neomycin allergy. Am J Dis Child. 1993;147(2):128–9.PubMed Kwittken PL, Rosen S, Sweinberg SK. MMR vaccine and neomycin allergy. Am J Dis Child. 1993;147(2):128–9.PubMed
46.
go back to reference Paulsen E, Otkjaer A, Andersen KE. Sesquiterpene lactone dermatitis in the young: is atopy a risk factor? Contact Dermatitis. 2008;59(1):1–6.PubMedCrossRef Paulsen E, Otkjaer A, Andersen KE. Sesquiterpene lactone dermatitis in the young: is atopy a risk factor? Contact Dermatitis. 2008;59(1):1–6.PubMedCrossRef
47.
go back to reference Belloni Fortina A, Romano I, Peserico A. Contact sensitization to Compositae mix in children. J Am Acad Dermatol. 2005;53(5):877–80.PubMedCrossRef Belloni Fortina A, Romano I, Peserico A. Contact sensitization to Compositae mix in children. J Am Acad Dermatol. 2005;53(5):877–80.PubMedCrossRef
48.
go back to reference Beattie PE, Green C, Lowe G, Lewis-Jones MS. Which children should we patch test? Clin Exp Dermatol. 2007;32(1):6–11.PubMed Beattie PE, Green C, Lowe G, Lewis-Jones MS. Which children should we patch test? Clin Exp Dermatol. 2007;32(1):6–11.PubMed
49.
go back to reference Jacob SE, Herro EM, Sullivan K, Matiz C, Eichenfield L, Hamann C. Safety and efficacy evaluation of TRUE TEST panels 1.1, 2.1, and 3.1 in children and adolescents. Dermatitis. 2011;22(4):204–10.PubMed Jacob SE, Herro EM, Sullivan K, Matiz C, Eichenfield L, Hamann C. Safety and efficacy evaluation of TRUE TEST panels 1.1, 2.1, and 3.1 in children and adolescents. Dermatitis. 2011;22(4):204–10.PubMed
50.
go back to reference Camacho-Halili M, Axelrod S, Michelis MA, et al. A multi-center, retrospective review of patch testing for contact dermatitis in allergy practices. Ann Allergy Asthma Immunol. 2011;107(6):487–92.PubMedCrossRef Camacho-Halili M, Axelrod S, Michelis MA, et al. A multi-center, retrospective review of patch testing for contact dermatitis in allergy practices. Ann Allergy Asthma Immunol. 2011;107(6):487–92.PubMedCrossRef
51.
go back to reference Davis MD, Bhate K, Rohlinger AL, Farmer SA, Richardson DM, Weaver AL. Delayed patch test reading after 5 days: the Mayo Clinic experience. J Am Acad Dermatol. 2008;59(2):225–33.PubMedCrossRef Davis MD, Bhate K, Rohlinger AL, Farmer SA, Richardson DM, Weaver AL. Delayed patch test reading after 5 days: the Mayo Clinic experience. J Am Acad Dermatol. 2008;59(2):225–33.PubMedCrossRef
52.
go back to reference Corazza M, Baldo F, Ricci M, Sarno O, Virgili A. Efficacy of new barrier socks in the treatment of foot allergic contact dermatitis. Acta Derm Venereol. 2011;91(1):68–9.PubMed Corazza M, Baldo F, Ricci M, Sarno O, Virgili A. Efficacy of new barrier socks in the treatment of foot allergic contact dermatitis. Acta Derm Venereol. 2011;91(1):68–9.PubMed
53.
go back to reference •• Fonacier LSMB. Contact Dermatitis: Elsevier Saunders; 2010. In depth reference on ACD in children with extensive discussion on pathogenesis, relevant allergens, diagnosis, and treatment. •• Fonacier LSMB. Contact Dermatitis: Elsevier Saunders; 2010. In depth reference on ACD in children with extensive discussion on pathogenesis, relevant allergens, diagnosis, and treatment.
54.
go back to reference Akdis CA, Akdis M, Bieber T, et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol. 2006;118(1):152–69.PubMedCrossRef Akdis CA, Akdis M, Bieber T, et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol. 2006;118(1):152–69.PubMedCrossRef
55.
go back to reference Luger T, Paul C. Potential new indications of topical calcineurin inhibitors. Dermatology. 2007;215 Suppl 1:45–54.PubMedCrossRef Luger T, Paul C. Potential new indications of topical calcineurin inhibitors. Dermatology. 2007;215 Suppl 1:45–54.PubMedCrossRef
56.
go back to reference Bekersky I, Fitzsimmons W, Tanase A, Maher RM, Hodosh E, Lawrence I. Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis. J Am Acad Dermatol. 2001;44(1 Suppl):S17–27.PubMedCrossRef Bekersky I, Fitzsimmons W, Tanase A, Maher RM, Hodosh E, Lawrence I. Nonclinical and early clinical development of tacrolimus ointment for the treatment of atopic dermatitis. J Am Acad Dermatol. 2001;44(1 Suppl):S17–27.PubMedCrossRef
57.
go back to reference Belsito D, Wilson DC, Warshaw E, et al. A prospective randomized clinical trial of 0.1 % tacrolimus ointment in a model of chronic allergic contact dermatitis. J Am Acad Dermatol. 2006;55(1):40–6.PubMedCrossRef Belsito D, Wilson DC, Warshaw E, et al. A prospective randomized clinical trial of 0.1 % tacrolimus ointment in a model of chronic allergic contact dermatitis. J Am Acad Dermatol. 2006;55(1):40–6.PubMedCrossRef
58.
go back to reference Katsarou A, Makris M, Papagiannaki K, Lagogianni E, Tagka A, Kalogeromitros D. Tacrolimus 0.1 % vs mometasone furoate topical treatment in allergic contact hand eczema: a prospective randomized clinical study. Eur J Dermatol. 2012;22(2):192–6.PubMed Katsarou A, Makris M, Papagiannaki K, Lagogianni E, Tagka A, Kalogeromitros D. Tacrolimus 0.1 % vs mometasone furoate topical treatment in allergic contact hand eczema: a prospective randomized clinical study. Eur J Dermatol. 2012;22(2):192–6.PubMed
59.
go back to reference Mrowietz U, Klein CE, Reich K, et al. Cyclosporine therapy in dermatology. J Dtsch Dermatol Ges. 2009;7(5):474–9.PubMed Mrowietz U, Klein CE, Reich K, et al. Cyclosporine therapy in dermatology. J Dtsch Dermatol Ges. 2009;7(5):474–9.PubMed
60.
go back to reference Heller M, Shin HT, Orlow SJ, Schaffer JV. Mycophenolate mofetil for severe childhood atopic dermatitis: experience in 14 patients. Br J Dermatol. 2007;157(1):127–32.PubMedCrossRef Heller M, Shin HT, Orlow SJ, Schaffer JV. Mycophenolate mofetil for severe childhood atopic dermatitis: experience in 14 patients. Br J Dermatol. 2007;157(1):127–32.PubMedCrossRef
61.
go back to reference Simon D. Systemic therapy of atopic dermatitis in children and adults. Curr Probl Dermatol. 2011;41:156–64.PubMedCrossRef Simon D. Systemic therapy of atopic dermatitis in children and adults. Curr Probl Dermatol. 2011;41:156–64.PubMedCrossRef
62.
go back to reference Granlund H, Erkko P, Reitamo S. Long-term follow-up of eczema patients treated with cyclosporine. Acta Derm Venereol. 1998;78(1):40–3.PubMedCrossRef Granlund H, Erkko P, Reitamo S. Long-term follow-up of eczema patients treated with cyclosporine. Acta Derm Venereol. 1998;78(1):40–3.PubMedCrossRef
63.
go back to reference Verma KK, Bansal A, Sethuraman G. Parthenium dermatitis treated with azathioprine weekly pulse doses. Indian J Dermatol Venereol Leprol. 2006;72(1):24–7.PubMedCrossRef Verma KK, Bansal A, Sethuraman G. Parthenium dermatitis treated with azathioprine weekly pulse doses. Indian J Dermatol Venereol Leprol. 2006;72(1):24–7.PubMedCrossRef
64.
go back to reference Granlund H, Erkko P, Eriksson E, Reitamo S. Comparison of cyclosporine and topical betamethasone-17,21-dipropionate in the treatment of severe chronic hand eczema. Acta Derm Venereol. 1996;76(5):371–6.PubMed Granlund H, Erkko P, Eriksson E, Reitamo S. Comparison of cyclosporine and topical betamethasone-17,21-dipropionate in the treatment of severe chronic hand eczema. Acta Derm Venereol. 1996;76(5):371–6.PubMed
65.
go back to reference Hon KL, Ching GK, Leung TF, Chow CM, Lee KK, Ng PC. Efficacy and tolerability at 3 and 6 months following use of azathioprine for recalcitrant atopic dermatitis in children and young adults. J Dermatolog Treat. 2009;20(3):141–5.PubMedCrossRef Hon KL, Ching GK, Leung TF, Chow CM, Lee KK, Ng PC. Efficacy and tolerability at 3 and 6 months following use of azathioprine for recalcitrant atopic dermatitis in children and young adults. J Dermatolog Treat. 2009;20(3):141–5.PubMedCrossRef
66.
go back to reference Brandao MH, Gontijo B, Girundi MA, de Castro MC. Ear piercing as a risk factor for contact allergy to nickel. J Pediatr (Rio J). 2010;86(2):149–54.CrossRef Brandao MH, Gontijo B, Girundi MA, de Castro MC. Ear piercing as a risk factor for contact allergy to nickel. J Pediatr (Rio J). 2010;86(2):149–54.CrossRef
67.
go back to reference Jensen CS, Lisby S, Baadsgaard O, Volund A, Menne T. Decrease in nickel sensitization in a Danish schoolgirl population with ears pierced after implementation of a nickel-exposure regulation. Br J Dermatol. 2002;146(4):636–42.PubMedCrossRef Jensen CS, Lisby S, Baadsgaard O, Volund A, Menne T. Decrease in nickel sensitization in a Danish schoolgirl population with ears pierced after implementation of a nickel-exposure regulation. Br J Dermatol. 2002;146(4):636–42.PubMedCrossRef
68.
go back to reference Thyssen JP. Nickel and cobalt allergy before and after nickel regulation–evaluation of a public health intervention. Contact Dermatitis. 2011;65 Suppl 1:1–68.CrossRef Thyssen JP. Nickel and cobalt allergy before and after nickel regulation–evaluation of a public health intervention. Contact Dermatitis. 2011;65 Suppl 1:1–68.CrossRef
69.
go back to reference Corrente S, Moschese V, Chianca M, et al. Temporary henna tattoo is unsafe in atopic children. Acta Paediatrica. 2007;96(3):469–71.PubMedCrossRef Corrente S, Moschese V, Chianca M, et al. Temporary henna tattoo is unsafe in atopic children. Acta Paediatrica. 2007;96(3):469–71.PubMedCrossRef
70.
go back to reference Jacob SE, Zapolanski T, Chayavichitsilp P, Connelly EA, Eichenfield LF. p-Phenylenediamine in black henna tattoos: a practice in need of policy in children. Arch Pediatr Adolesc Med. 2008;162(8):790–2.PubMedCrossRef Jacob SE, Zapolanski T, Chayavichitsilp P, Connelly EA, Eichenfield LF. p-Phenylenediamine in black henna tattoos: a practice in need of policy in children. Arch Pediatr Adolesc Med. 2008;162(8):790–2.PubMedCrossRef
71.
Metadata
Title
Current Strategies in Treating Severe Contact Dermatitis in Pediatric Patients
Authors
Luz S. Fonacier
Marcella R. Aquino
Tania Mucci
Publication date
01-12-2012
Publisher
Current Science Inc.
Published in
Current Allergy and Asthma Reports / Issue 6/2012
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-012-0305-0

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