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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 1/2011

Open Access 01-02-2011

Innate Signaling in Otitis Media: Pathogenesis and Recovery

Authors: Anke Leichtle, Yuping Lai, Barbara Wollenberg, Stephen I. Wasserman, Allen F. Ryan

Published in: Current Allergy and Asthma Reports | Issue 1/2011

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Abstract

Otitis media (OM) is the most prevalent childhood disease in developed countries. Involvement of innate immunity mediated by Toll-like receptors (TLRs) in OM has been implicated primarily in cell lines and by association studies of innate immune gene polymorphisms with OM prevalence. However, the precise role of innate immunity in OM is incompletely understood. We review recent research that has advanced our understanding of how innate immunity in the middle ear is mediated by the interaction of pathogen molecules with receptors such as the TLRs, leading to the activation of adaptor molecules and production of proinflammatory cytokines. TLR genes and signaling molecules are upregulated in OM in a murine model. Deletion of several key innate immune genes results in persistent OM in mice, coupled with an inability to clear bacterial infection from the middle ear. It is concluded that an intact innate immune signaling system is critical to recovery from bacterial OM.
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Metadata
Title
Innate Signaling in Otitis Media: Pathogenesis and Recovery
Authors
Anke Leichtle
Yuping Lai
Barbara Wollenberg
Stephen I. Wasserman
Allen F. Ryan
Publication date
01-02-2011
Publisher
Current Science Inc.
Published in
Current Allergy and Asthma Reports / Issue 1/2011
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-010-0158-3

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