Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 1/2011

Open Access 01-02-2011

Perspectives on Anaphylaxis Epidemiology in the United States with New Data and Analyses

Authors: Zuber D. Mulla, Robert Y. Lin, Michael R. Simon

Published in: Current Allergy and Asthma Reports | Issue 1/2011

Login to get access

Abstract

Anaphylaxis incidence rates and time trends in the United States have been reported using different data sources and selection methods. Larger studies using diagnostic coding have inherent limitations in sensitivity and specificity. In contrast, smaller studies using chart reviews, including reports from single institutions, have better case characterization but suffer from reduced external validity due to their restricted nature. Increasing anaphylaxis hospitalization rates since the 1990s have been reported abroad. However, we report no significant overall increase in the United States. There have been several reports of increasing anaphylaxis rates in northern populations in the United States, especially in younger people, lending support to the suggestion that higher anaphylaxis rates occur at higher latitudes. We analyzed anaphylaxis hospitalization rates in comparably sized northern (New York) and southern (Florida) states and found significant time trend differences based on age. This suggests that the relationship of latitude to anaphylaxis incidence is complex.
Literature
1.
An epidemiologic study of severe anaphylactic and anaphylactoid reactions among hospital patients: methods and overall risks. The International Collaborative Study of Severe Anaphylaxis. Epidemiology 1998, 9:141–146.
2.
3.
Laxenaire MC, Mertes PM; Groupe d’Etudes des Réactions Anaphylactoïdes Peranesthésiques: Anaphylaxis during anaesthesia. Results of a two-year survey in France. Br J Anaesth 2001, 87:549–558.CrossRefPubMed
4.
Bock SA, Muñoz-Furlong A, Sampson HA: Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001, 107:191–193.CrossRefPubMed
5.
Moneret-Vautrin DA, Kanny G, Parisot L: First survey from the “Allergy Vigilance Network”: life-threatening food allergies in France. Allerg Immunol (Paris) 2002, 34:194–198.
6.
A Dictionary of Epidemiology, edn 5. Edited by Porta M. New York: Oxford University Press; 2008:187.
7.
Hennekens CH, Buring JE, eds: Epidemiology in Medicine. Boston, MA: Little, Brown and Co.; 1987:81.
8.
Mulla ZD, Simon MR: Hospitalizations for anaphylaxis in Florida: epidemiologic analysis of a population-based dataset. Int Arch Allergy Immunol 2007, 144:128–136.CrossRefPubMed
9.
Bohlke K, Davis RL, DeStefano F, et al.; Vaccine Safety Datalink Team: Epidemiology of anaphylaxis among children and adolescents enrolled in a health maintenance organization. J Allergy Clin Immunol 2004, 113:536–542.CrossRefPubMed
10.
Sampson HA, Muñoz-Furlong A, Campbell RL, et al.: Second symposium on the definition and management of anaphylaxis: summary report—Second National Institute of Allergy and Infectious Diseases/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol 2006, 117:391–397.CrossRefPubMed
11.
Klein JS, Yocum MW: Underreporting of anaphylaxis in a community emergency room. J Allergy Clin Immunol 1995, 95:637–638.CrossRefPubMed
12.
Yocum MW, Butterfield JH, Klein JS, et al.: Epidemiology of anaphylaxis in Olmsted County: a population-based study. J Allergy Clin Immunol 1999, 104:452–456.CrossRefPubMed
13.
Decker WW, Campbell RL, Manivannan V, et al.: The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project. J Allergy Clin Immunol 2008, 122:1161–1165.CrossRefPubMed
14.
Peng MM, Jick H: A population-based study of the incidence, cause, and severity of anaphylaxis in the United Kingdom. Arch Intern Med 2004, 164:317–319.CrossRefPubMed
15.
Sheikh A, Hippisley-Cox J, Newton J, Fenty J: Trends in national incidence, lifetime prevalence and adrenaline prescribing for anaphylaxis in England. J R Soc Med 2008, 101:139–143.CrossRefPubMed
16.
• Iribarren C, Tolstykh IV, Miller MK, Eisner MD: Asthma and the prospective risk of anaphylactic shock and other allergy diagnoses in a large integrated health care delivery system. Ann Allergy Asthma Immunol 2010, 104:371–377. This was a high-quality cohort study of the incidence of anaphylaxis in a regional US population. While its objective was to determine the incidence of anaphylaxis in an asthma cohort, it also provides the incidence of anaphylaxis in the nonasthmatic referent cohort of more than 500,000 people. CrossRefPubMed
17.
• Simon MR, Mulla ZD: A population-based epidemiologic analysis of deaths from anaphylaxis in Florida. Allergy 2008, 63:1077–1083. This is the only US population-based study of anaphylactic deaths in a large population (>15 million people). It is the only study to determine the relative risk of death from anaphylaxis by age and location. It also documents that anaphylactic deaths occur preferentially during certain months. CrossRefPubMed
18.
• Harduar-Morano L, Simon MR, Watkins S, Blackmore C: Algorithm for the diagnosis of anaphylaxis and its validation using population-based data on emergency department visits for anaphylaxis in Florida. J Allergy Clin Immunol 2010, 126:98–104.e4. This study presents and validates an ICD-9-CM–based diagnostic algorithm that allows for a more accurate estimate of anaphylaxis incidence by capturing previously unidentified cases, especially venom-induced cases. The use of the algorithm more than doubles the number of cases identified. CrossRef
19.
20.
Helbling A, Hurni T, Mueller UR, Pichler WJ: Incidence of anaphylaxis with circulatory symptoms: a study over a 3-year period comprising 940,000 inhabitants of the Swiss Canton Bern. Clin Exp Allergy 2004, 34:285–290.CrossRefPubMed
21.
Poulos LM, Waters A-M, Correl PK, et al.: Trends in hospitalizations for anaphylaxis, angiooedema, and urticaria in Australia, 1993–1994 to 2004–2005. J Allergy Clin Immunol 2007, 120:878–884.CrossRefPubMed
22.
Gupta R, Sheikh A, Strachan DP, Anderson HR: Time trends in allergic disorders in the UK. Thorax 2007, 62:91–96.CrossRefPubMed
23.
Lin RY, Shah SN: Increasing hospitalizations due to angioedema in the United States. Ann Allergy Asthma Immunol 2008, 101:185–192.CrossRefPubMed
24.
Lin RY, Anderson AS, Shah SN, Nurruzzaman F: Increasing anaphylaxis hospitalizations in the first 2 decades of life: New York State, 1990–2006. Ann Allergy Asthma Immunol 2008, 101:387–393.CrossRefPubMed
25.
26.
27.
28.
Camargo CA Jr, Clark S, Kaplan MS, et al.: Regional differences in EpiPen prescriptions in the United States: the potential role of vitamin D. J Allergy Clin Immunol 2007, 120:131–136.CrossRefPubMed
29.
Mullins RJ, Clark S, Camargo CA Jr: Regional variation in epinephrine autoinjector prescriptions in Australia: more evidence for the vitamin D-anaphylaxis hypothesis. Ann Allergy Asthma Immunol 2009, 103:488–495.CrossRefPubMed
30.
Rudders SA, Espinola JA, Camargo CA Jr: North-south differences in US emergency department visits for acute allergic reactions. Ann Allergy Asthma Immunol 2010, 104:413–416.CrossRefPubMed
31.
Allison PD: Poisson regression. In Logistic Regression Using the SAS System: Theory and Application. Cary, NC: SAS Institute; 1999:217–231.
32.
Szklo M, Nieto FJ: Epidemiology Beyond the Basics. Gaithersburg: Aspen; 2000:310–311.
33.
Greenland S: Modeling and variable selection in epidemiologic analysis. Am J Public Health 1989, 79:340–349.CrossRefPubMed
34.
Fisher ES, Whaley FS, Krushat WM, et al.: The accuracy of Medicare’s hospital claims data: progress has been made, but problems remain. Am J Public Health 1992, 82:243–248.CrossRefPubMed
35.
36.
37.
Lydon-Rochelle MT, Holt VL, Nelson JC, et al.: Accuracy of reporting maternal in-hospital diagnoses and intrapartum procedures in Washington state linked birth records. Paediatr Perinat Epidemiol 2005, 19:460–471.CrossRefPubMed
38.
Yasmeen S, Romano PS, Schembri ME, et al.: Accuracy of obstetric diagnoses and procedures in hospital discharge data. Am J Obstet Gynecol 2006, 194:992–1001.CrossRefPubMed
39.
Kelsey JL, Whittemore AS, Evans AS, Thompson WD: Methods in Observational Epidemiology, edn 2. New York: Oxford University Press; 1996:342–348.
40.
West SL, D’Aloisio AA, Ringel-Kulka T, et al.: Population based drug-related anaphylaxis in children and adolescents captured by South Carolina Emergency Room Hospital Discharge Database (SCERHDD) (2000–2002). Pharmacoepidemiol Drug Saf 2007, 16:1255–1267.CrossRefPubMed
Metadata
Title
Perspectives on Anaphylaxis Epidemiology in the United States with New Data and Analyses
Authors
Zuber D. Mulla
Robert Y. Lin
Michael R. Simon
Publication date
01-02-2011
Publisher
Current Science Inc.
Published in
Current Allergy and Asthma Reports / Issue 1/2011
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-010-0154-7

Other articles of this Issue 1/2011

Current Allergy and Asthma Reports 1/2011 Go to the issue

ReviewPaper

The Impact of Vitamin D on Regulatory T Cells

Clinical Trial Report

The Role of Vitamin D in Asthmatic Children

ReviewPaper

Interleukin-33 in Asthma: How Big of a Role Does It Play?

ReviewPaper

Allergic Reactions to Clopidogrel and Cross-Reactivity to Other Agents

ReviewPaper

The Role of the Histamine H4 Receptor in Atopic Dermatitis

ReviewPaper

Innate Signaling in Otitis Media: Pathogenesis and Recovery