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01-02-2008 | Current Concept Review

Genetic Regulation of Embryological Limb Development with Relation to Congenital Limb Deformity in Humans

Authors: Guy Barham, Nicholas M. P. Clarke

Published in: Journal of Children's Orthopaedics | Issue 1/2008

Abstract

Over the last 15 years, great improvements in genetic engineering and genetic manipulation strategies have led to significant advances in the understanding of the genetics governing embryological limb development. This field of science continues to develop, and the complex genetic interactions and signalling pathways are still not fully understood. In this review we will discuss the roles of the principle genes involved in the three-dimensional patterning of the developing limb and will discuss how errors in these signalling cascades correlate to congenital limb deformity in humans. This review is aimed at orthopaedic surgeons wishing to understand the principles of congenital limb deformity related to genetic signalling errors. It is by no means a comprehensive study of the molecular genetics governing the complex interactions involved in each step of limb development. There are however many syndromes involving limb deformity for which the molecular causes are unknown.

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Title: Genetic Regulation of Embryological Limb Development with Relation to Congenital Limb Deformity in Humans
Authors: Guy Barham
Nicholas M. P. Clarke
Publication date: 01-02-2008
Publisher: Springer Berlin Heidelberg
Published in: Journal of Children's Orthopaedics / Issue 1/2008
Print ISSN: 1863-2521
Electronic ISSN: 1863-2548
DOI: https://doi.org/10.1007/s11832-008-0076-2

2024 ASCO Annual Meeting

Springer Medicine

Genetic Regulation of Embryological Limb Development with Relation to Congenital Limb Deformity in Humans

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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