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01-06-2016

The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial

Authors: James L. Devin, Andrew T. Sax, Gareth I. Hughes, David G. Jenkins, Joanne F. Aitken, Suzanne K. Chambers, Jeffrey C. Dunn, Kate A. Bolam, Tina L. Skinner

Published in: Journal of Cancer Survivorship | Issue 3/2016

Abstract

Purpose

Following colorectal cancer diagnosis and anti-cancer therapy, declines in cardiorespiratory fitness and body composition lead to significant increases in morbidity and mortality. There is increasing interest within the field of exercise oncology surrounding potential strategies to remediate these adverse outcomes. This study compared 4 weeks of moderate-intensity exercise (MIE) and high-intensity exercise (HIE) training on peak oxygen consumption (V̇O₂peak) and body composition in colorectal cancer survivors.

Methods

Forty seven post-treatment colorectal cancer survivors (HIE = 27 months post-treatment; MIE = 38 months post-treatment) were randomised to either HIE [85–95 % peak heart rate (HR_peak)] or MIE (70 % HR_peak) in equivalence with current physical activity guidelines and completed 12 training sessions over 4 weeks.

Results

HIE was superior to MIE in improving absolute (p = 0.016) and relative (p = 0.021) V̇O₂peak. Absolute (+0.28 L.min⁻¹, p < 0.001) and relative (+3.5 ml.kg⁻¹.min⁻¹, p < 0.001) V̇O₂ peak were increased in the HIE group but not the MIE group following training. HIE led to significant increases in lean mass (+0.72 kg, p = 0.002) and decreases in fat mass (−0.74 kg, p < 0.001) and fat percentage (−1.0 %, p < 0.001), whereas no changes were observed for the MIE group. There were no severe adverse events.

Conclusions

In response to short-term training, HIE is a safe, feasible and efficacious intervention that offers clinically meaningful improvements in cardiorespiratory fitness and body composition for colorectal cancer survivors.

Implications for Cancer Survivors

HIE appears to offer superior improvements in cardiorespiratory fitness and body composition in comparison to current physical activity recommendations for colorectal cancer survivors and therefore may be an effective clinical utility following treatment.

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Title: The influence of high-intensity compared with moderate-intensity exercise training on cardiorespiratory fitness and body composition in colorectal cancer survivors: a randomised controlled trial
Authors: James L. Devin
Andrew T. Sax
Gareth I. Hughes
David G. Jenkins
Joanne F. Aitken
Suzanne K. Chambers
Jeffrey C. Dunn
Kate A. Bolam
Tina L. Skinner
Publication date: 01-06-2016
Publisher: Springer US
Published in: Journal of Cancer Survivorship / Issue 3/2016
Print ISSN: 1932-2259
Electronic ISSN: 1932-2267
DOI: https://doi.org/10.1007/s11764-015-0490-7

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