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General Thoracic and Cardiovascular Surgery
Published in: General Thoracic and Cardiovascular Surgery 9/2021

01-09-2021 | NSCLC | Original Article

Differential impacts of postoperative complications on patients’ survival in completely resected non-small-cell lung cancer

Authors: Yuka Kadomatsu, Hideki Tsubouchi, Keita Nakanishi, Tomoshi Sugiyama, Harushi Ueno, Masaki Goto, Naoki Ozeki, Shota Nakamura, Takayuki Fukui, Toyofumi Fengshi Chen-Yoshikawa

Published in: General Thoracic and Cardiovascular Surgery | Issue 9/2021

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Abstract

Objective

The aim of this study was to investigate the effects of inflammatory respiratory complications on long-term survival in patients with resected non-small cell lung cancer. We defined inflammatory respiratory complications to include the following six conditions: pneumonia, empyema, bronchial fistula, respiratory dysfunction, acute interstitial pneumonia, and atelectasis.

Methods

Part of the National Clinical Database was linked to our prospective database from 2014 to 2017. Linkage was achieved for 866 patients. The Kaplan–Meier method was used to evaluate the overall, relapse-free, and cancer-related survival. The Cox proportional hazard model was used to analyze the impact of each complication.

Results

Of the 736 patients included in the study, 149 had complications. The 5-year overall and cancer-specific survival rates were significantly lower in patients with inflammatory respiratory complications. The Cox proportional hazard model showed that the inflammatory respiratory complications had a significant impact on overall survival (hazard ratio 2.48, 95% confidence interval 1.41–4.38) but not air leak (hazard ratio 1.38, 95% confidence interval 0.70–2.70).

Conclusions

Our study shows the differential impact of each complication on the survival of patients with non-small cell lung cancer. The presence of inflammatory respiratory complications was the only predictor of poor overall survival.
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Metadata
Title
Differential impacts of postoperative complications on patients’ survival in completely resected non-small-cell lung cancer
Authors
Yuka Kadomatsu
Hideki Tsubouchi
Keita Nakanishi
Tomoshi Sugiyama
Harushi Ueno
Masaki Goto
Naoki Ozeki
Shota Nakamura
Takayuki Fukui
Toyofumi Fengshi Chen-Yoshikawa
Publication date
01-09-2021
Publisher
Springer Singapore
Published in
General Thoracic and Cardiovascular Surgery / Issue 9/2021
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-021-01619-z

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