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General Thoracic and Cardiovascular Surgery

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01-07-2018 | Original Article

Granulocyte colony stimulating factor-producing lung cancer with severe anemia of inflammation

Authors: Koutaro Murakami, Yujin Kudo, Masatoshi Kakihana, Jun Matsubayashi, Tetsuya Okano, Yoshihisa Shimada, Toshitaka Nagao, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda

Published in: General Thoracic and Cardiovascular Surgery | Issue 7/2018

Abstract

Granulocyte colony stimulating factor (G-CSF)-producing lung cancer occasionally induces severe inflammation with an abnormally high white blood cell count. Herein, we report a 49-year-old man who suffered from resectable G-CSF-producing non-small cell lung cancer with continuous fever and severe anemia. Red blood cell transfusion was necessary for the anemia of inflammation. The patient underwent complete surgical tumor resection. The histopathological diagnosis was a pleomorphic carcinoma at pathological stage IIB. This is apparently the first successful case of surgical resection of G-CSF-producing lung cancer in a patient with severe anemia and uncontrollable fever.

Kasuga I, Makino S, Kiyokawa H, Katoh H, Ebihara Y, Ohyashiki K. Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma. Cancer. 2001;92(9):2399–405.CrossRefPubMed

Asano S, Urabe A, Okabe T, Sato N, Kondo Y. Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. Blood. 1977;49(5):845–52.PubMed

Wada H, Yoshida S, Ishibashi F, Mizobuchi T, Moriya Y, Hoshino H, et al. Pleomorphic carcinoma of the lung producing granulocyte colony-stimulating factor: report of a case. Surg Today. 2011;41(8):1161–5.CrossRefPubMed

Yamamoto M, Manabe S, Moriyama Y, Ishii H, Tanaka S, Takahashi R, et al. Long-term remission achieved via combined chemotherapy and radiotherapy in a non-resectable granulocyte colony-stimulating factor producing pleomorphic carcinoma of the lung. Intern Med. 2013;52(19):2259–63.CrossRefPubMed

Matsumoto M, Nakayama T, Inoue D, Takamatsu K, Itotani R, Ishitoko M, et al. A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity. BMC Cancer. 2014;14:588.CrossRefPubMedPubMedCentral

Title: Granulocyte colony stimulating factor-producing lung cancer with severe anemia of inflammation
Authors: Koutaro Murakami
Yujin Kudo
Masatoshi Kakihana
Jun Matsubayashi
Tetsuya Okano
Yoshihisa Shimada
Toshitaka Nagao
Naohiro Kajiwara
Tatsuo Ohira
Norihiko Ikeda
Publication date: 01-07-2018
Publisher: Springer Japan
Published in: General Thoracic and Cardiovascular Surgery / Issue 7/2018
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI: https://doi.org/10.1007/s11748-018-0914-1

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Springer Medicine

Granulocyte colony stimulating factor-producing lung cancer with severe anemia of inflammation

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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