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Published in: Obesity Surgery 11/2018

01-11-2018 | Original Contributions

Bariatric Surgery in Patients with Cirrhosis and Portal Hypertension

Authors: Zubaidah Nor Hanipah, Suriya Punchai, Arthur McCullough, Srinivasan Dasarathy, Stacy A. Brethauer, Ali Aminian, Philip R. Schauer

Published in: Obesity Surgery | Issue 11/2018

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Abstract

Introduction

Studies on bariatric patients with cirrhosis and portal hypertension are limited. The aim of this study was to review our experience in cirrhotic patients with portal hypertension who had bariatric surgery.

Method

All cirrhotic patients with portal hypertension who underwent laparoscopic bariatric surgery, from 2007 to 2017, were retrospectively reviewed.

Results

Thirteen patients were included; eight (62%) were female. The median age was 54 years (interquartile range, IQR 49–60) and median BMI was 48 kg/m2 (IQR 43–55). Portal hypertension was diagnosed based on endoscopy (n = 5), imaging studies (n = 3), intraoperative increased collateral circulation (n = 2), and endoscopy and imaging studies (n = 3). The bariatric procedures included sleeve gastrectomy (n = 10, 77%) and Roux-en-Y gastric bypass (n = 3, 23%). The median length of hospital stay was 3 days (IQR 2–4). Three 30-day complications occurred including wound infection (n = 1), intra-abdominal hematoma (n = 1), and subcutaneous hematoma (n = 1). No intraoperative or 30-day mortalities. There were 11 patients (85%) at 1-year follow-up and 9 patients (69%) at 2-year follow-up. At 2 years, the median percentage of excess weight loss (EWL) and total weight loss (TWL) were 49 and 25%, respectively. There was significant improvement in diabetes (100%), dyslipidemia (100%), and hypertension (50%) at 2 years after surgery.

Conclusion

Bariatric surgery in selected cirrhotic patients with portal hypertension is relatively safe and effective.
Literature
1.
go back to reference Hanipah ZN, Schauer PR. Surgical treatment of obesity and diabetes. Gastrointest Endosc Clin N Am. 2017;27(2):191–211.CrossRefPubMed Hanipah ZN, Schauer PR. Surgical treatment of obesity and diabetes. Gastrointest Endosc Clin N Am. 2017;27(2):191–211.CrossRefPubMed
2.
go back to reference Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51:679–89.CrossRefPubMed Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51:679–89.CrossRefPubMed
3.
go back to reference Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol. 2006;40:S5–10.PubMed Clark JM. The epidemiology of nonalcoholic fatty liver disease in adults. J Clin Gastroenterol. 2006;40:S5–10.PubMed
4.
go back to reference Wong RJ, Aguilar M, Cheung R, et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology. 2015;148:547–55.CrossRefPubMed Wong RJ, Aguilar M, Cheung R, et al. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology. 2015;148:547–55.CrossRefPubMed
5.
go back to reference Schauer PR, Bhatt DL, Kirwan JP, et al. STAMPEDE investigators. Metabolic surgery vs. intensive medical therapy for diabetes: 5-year outcomes. N Engl J Med. 2017;376:641–51.CrossRefPubMedPubMedCentral Schauer PR, Bhatt DL, Kirwan JP, et al. STAMPEDE investigators. Metabolic surgery vs. intensive medical therapy for diabetes: 5-year outcomes. N Engl J Med. 2017;376:641–51.CrossRefPubMedPubMedCentral
6.
go back to reference Schauer PR, Mingrone G, Ikramuddin S, et al. Clinical outcomes of metabolic surgery: efficacy of glycemic control, weight loss, and remission of diabetes. Diabetes Care. 2016;39:902–11.CrossRefPubMedPubMedCentral Schauer PR, Mingrone G, Ikramuddin S, et al. Clinical outcomes of metabolic surgery: efficacy of glycemic control, weight loss, and remission of diabetes. Diabetes Care. 2016;39:902–11.CrossRefPubMedPubMedCentral
7.
go back to reference Targher G, Arcaro G. Non-alcoholic fatty liver disease and increased risk of cardiovascular disease. Atherosclerosis. 2007;191:235–40.CrossRefPubMed Targher G, Arcaro G. Non-alcoholic fatty liver disease and increased risk of cardiovascular disease. Atherosclerosis. 2007;191:235–40.CrossRefPubMed
8.
go back to reference Targher G, Byrne CD, Lonardo A, et al. Nonalcoholic fatty liver disease and risk of incident cardiovascular disease: a meta-analysis of observational studies. J Hepatol. 2016;65:589–600.CrossRefPubMed Targher G, Byrne CD, Lonardo A, et al. Nonalcoholic fatty liver disease and risk of incident cardiovascular disease: a meta-analysis of observational studies. J Hepatol. 2016;65:589–600.CrossRefPubMed
9.
go back to reference Adams LA, Lymp JF, Sauver JS, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129:113–21.CrossRefPubMed Adams LA, Lymp JF, Sauver JS, et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology. 2005;129:113–21.CrossRefPubMed
10.
go back to reference Rabl C, Campos GM. The impact of bariatric surgery on nonalcoholic steatohepatitis. Semin Liver Dis. 2012;32:80–91.CrossRefPubMed Rabl C, Campos GM. The impact of bariatric surgery on nonalcoholic steatohepatitis. Semin Liver Dis. 2012;32:80–91.CrossRefPubMed
11.
go back to reference Neeff H, Mariaskin D, Spangenberg HC, et al. Perioperative mortality after non-hepatic general surgery in patients with liver cirrhosis: an analysis of 138 operations in the 2000s using child and MELD scores. J Gastrointest Surg. 2011;15:1–11.CrossRefPubMed Neeff H, Mariaskin D, Spangenberg HC, et al. Perioperative mortality after non-hepatic general surgery in patients with liver cirrhosis: an analysis of 138 operations in the 2000s using child and MELD scores. J Gastrointest Surg. 2011;15:1–11.CrossRefPubMed
12.
go back to reference Mosko JD, Nguyen GC. Increased perioperative mortality following bariatric surgery among patients with cirrhosis. Clin Gastroenterol Hepatol. 2011;9:897–901.CrossRefPubMed Mosko JD, Nguyen GC. Increased perioperative mortality following bariatric surgery among patients with cirrhosis. Clin Gastroenterol Hepatol. 2011;9:897–901.CrossRefPubMed
14.
go back to reference Pestana L, Swain J, Dierkhising R, et al. Bariatric surgery in patients with cirrhosis with and without portal hypertension: a single-center experience. Mayo Clin Proc. 2015;90:209–15.CrossRefPubMed Pestana L, Swain J, Dierkhising R, et al. Bariatric surgery in patients with cirrhosis with and without portal hypertension: a single-center experience. Mayo Clin Proc. 2015;90:209–15.CrossRefPubMed
15.
go back to reference Groszmann R, Vorobioff JD, Gao H. Measurement of portal pressure: when, how, and why to do it. Clin Liver Dis. 2006;10:499–512. viiiCrossRefPubMed Groszmann R, Vorobioff JD, Gao H. Measurement of portal pressure: when, how, and why to do it. Clin Liver Dis. 2006;10:499–512. viiiCrossRefPubMed
16.
go back to reference Thalheimer U, Bellis L, Puoti C, et al. Should we routinely measure portal pressure in patients with cirrhosis, using hepatic venous pressure gradient (HVPG) as a guide for prophylaxis and therapy of bleeding and rebleeding? No. Eur J Intern Med. 2011;22:5–7.CrossRefPubMed Thalheimer U, Bellis L, Puoti C, et al. Should we routinely measure portal pressure in patients with cirrhosis, using hepatic venous pressure gradient (HVPG) as a guide for prophylaxis and therapy of bleeding and rebleeding? No. Eur J Intern Med. 2011;22:5–7.CrossRefPubMed
17.
go back to reference Brethauer SA, Kim J, El Chaar M, et al. Standardized outcomes reporting in metabolic and bariatric surgery. Surg Obes Relat Dis. 2015;11:489–506.CrossRefPubMed Brethauer SA, Kim J, El Chaar M, et al. Standardized outcomes reporting in metabolic and bariatric surgery. Surg Obes Relat Dis. 2015;11:489–506.CrossRefPubMed
18.
go back to reference American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care. 2017;40(Supplement 1):S11–24.CrossRef American Diabetes Association. 2. Classification and diagnosis of diabetes. Diabetes Care. 2017;40(Supplement 1):S11–24.CrossRef
19.
go back to reference American Diabetes Association. 9. Cardiovascular disease and risk management. Diabetes Care. 2017;40(Supplement 1):S75–87.CrossRef American Diabetes Association. 9. Cardiovascular disease and risk management. Diabetes Care. 2017;40(Supplement 1):S75–87.CrossRef
20.
go back to reference Dallal RM, Mattar SG, Lord JL, et al. Results of laparoscopic gastric bypass in patients with cirrhosis. Obes Surg. 2004;14:47–53.CrossRefPubMed Dallal RM, Mattar SG, Lord JL, et al. Results of laparoscopic gastric bypass in patients with cirrhosis. Obes Surg. 2004;14:47–53.CrossRefPubMed
21.
go back to reference Shimizu H, Phuong V, Maia M, et al. Bariatric surgery in patients with liver cirrhosis. Surg Obes Relat Dis. 2013;9:1–6.CrossRefPubMed Shimizu H, Phuong V, Maia M, et al. Bariatric surgery in patients with liver cirrhosis. Surg Obes Relat Dis. 2013;9:1–6.CrossRefPubMed
22.
go back to reference Jan A, Narwaria M, Mahawar KK. A systematic review of bariatric surgery in patients with liver cirrhosis. Obes Surg. 2015;25:1518–26.CrossRefPubMed Jan A, Narwaria M, Mahawar KK. A systematic review of bariatric surgery in patients with liver cirrhosis. Obes Surg. 2015;25:1518–26.CrossRefPubMed
23.
go back to reference Kim JJ, Dasika NL, Yu E, et al. Cirrhotic patients with a transjugular intrahepatic portosystemic shunt undergoing major extrahepatic surgery. J Clin Gastroenterol. 2009;43:574–9.CrossRefPubMed Kim JJ, Dasika NL, Yu E, et al. Cirrhotic patients with a transjugular intrahepatic portosystemic shunt undergoing major extrahepatic surgery. J Clin Gastroenterol. 2009;43:574–9.CrossRefPubMed
Metadata
Title
Bariatric Surgery in Patients with Cirrhosis and Portal Hypertension
Authors
Zubaidah Nor Hanipah
Suriya Punchai
Arthur McCullough
Srinivasan Dasarathy
Stacy A. Brethauer
Ali Aminian
Philip R. Schauer
Publication date
01-11-2018
Publisher
Springer US
Published in
Obesity Surgery / Issue 11/2018
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-018-3372-z

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