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Obesity Surgery
Published in: Obesity Surgery 9/2016

Open Access 01-09-2016 | Original Contributions

A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery

Authors: Marcus Bandstein, Sarah Voisin, Emil K. Nilsson, Bernd Schultes, Barbara Ernst, Martin Thurnheer, Christian Benedict, Jessica Mwinyi, Helgi B. Schiöth

Published in: Obesity Surgery | Issue 9/2016

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Abstract

Background

Currently, Roux-en Y gastric bypass (RYGB) is the most efficient therapy for severe obesity. Weight loss after surgery is, however, highly variable and genetically influenced. Genome-wide association studies have identified several single nucleotide polymorphisms (SNP) associated with body mass index (BMI) and waist-hip ratio (WHR). We aimed to identify two genetic risk scores (GRS) composed of weighted BMI and WHR-associated SNPs to estimate their impact on excess BMI loss (EBMIL) after RYGB surgery.

Methods

Two hundred and thirty-eight obese patients (BMI 45.1 ± 6.2 kg/m2, 74 % women), who underwent RYGB, were genotyped for 35 BMI and WHR-associated SNPs and were followed up after 2 years. SNPs with high impact on post-surgical weight loss were filtered out using a random forest model. The filtered SNPs were combined into a GRS and analyzed in a linear regression model.

Results

An up to 11 % lower EBMIL with higher risk score was estimated for two GRS models (P = 0.026 resp. P = 0.021) composed of seven BMI-associated SNPs (closest genes: MC4R, TMEM160, PTBP2, NUDT3, TFAP2B, ZNF608, MAP2K5, GNPDA2, and MTCH2) and of three WHR-associated SNPs (closest genes: HOXC13, LYPLAL1, and DNM3-PIGC). Patients within the lowest GRS quartile had higher EBMIL compared to patients within the other three quartiles in both models.

Conclusions

We identified two GRSs composed of BMI and WHR-associated SNPs with significant impact on weight loss after RYGB surgery using random forest analysis as a SNP selection tool. The GRS may be useful to pre-surgically evaluate the risks for patients undergoing RYGB surgery.
Appendix
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Metadata
Title
A Genetic Risk Score Is Associated with Weight Loss Following Roux-en Y Gastric Bypass Surgery
Authors
Marcus Bandstein
Sarah Voisin
Emil K. Nilsson
Bernd Schultes
Barbara Ernst
Martin Thurnheer
Christian Benedict
Jessica Mwinyi
Helgi B. Schiöth
Publication date
01-09-2016
Publisher
Springer US
Published in
Obesity Surgery / Issue 9/2016
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-016-2072-9

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