Skip to main content
Top
Published in: Obesity Surgery 5/2015

01-05-2015 | Original Contributions

Rates of Reflux Before and After Laparoscopic Sleeve Gastrectomy for Severe Obesity

Authors: Caroline E. Sheppard, Daniel C. Sadowski, Christopher J. de Gara, Shahzeer Karmali, Daniel W. Birch

Published in: Obesity Surgery | Issue 5/2015

Login to get access

Abstract

Background

A current management dilemma in laparoscopic sleeve gastrectomy (LSG) patients is the development of significant gastroesophageal reflux symptoms after surgery. Treatment is typically directed towards reducing acid reflux despite the surgical removal of parietal cell mass. In contrast, laparoscopic Roux-en-Y gastric bypass (LRYGB) has been known to reduce or resolve preoperative reflux symptoms. The objective of this study was to determine the incidence of preoperative and postoperative reflux of LSG and LRYGB patients, and review reflux treatment type and response.

Methods

A retrospective chart review was performed for patients undergoing either LSG or LRYGB between January 2010 and December 2012 as part of the Weight Wise program, Royal Alexandra Hospital, Edmonton, Canada.

Results

A total of 387 cases were included in our review. We observed a significant reduction in BMI postoperatively for both LSG and LRYGB groups (p < 0.001). Between surgical groups, preoperative proton-pump inhibitor (PPI) use was not significantly different; however, at 1 month (p < 0.05) to 1–2 years (p < 0.001), there was significantly increased PPI use in patients after LSG in comparison to LRYGB. Of the LSG patients that continued their PPI treatment after surgery, 58 % increased, 42 % continued the same, and 0 % decreased their dose 1 year after surgery.

Conclusions

Reflux symptoms are significantly increased after LSG in comparison to LRYGB patients. In addition, LSG patients more frequently require initiation of reflux treatment after surgery than that of LRYGB patients. Patients reported postoperative reflux symptom relief with acid-suppressant therapies.
Literature
1.
go back to reference Todkar J, Shah S, Shah P, et al. Long-term effects of laparoscopic sleeve gastrectomy in morbidly obese subjects with type 2 diabetes mellitus. Surg Obes Relat Dis. 2010;6:142–5.CrossRefPubMed Todkar J, Shah S, Shah P, et al. Long-term effects of laparoscopic sleeve gastrectomy in morbidly obese subjects with type 2 diabetes mellitus. Surg Obes Relat Dis. 2010;6:142–5.CrossRefPubMed
2.
go back to reference Snyder-Marlow G, Taylor D, Lenhard J. Nutrition care for patients undergoing laparoscopic sleeve gastrectomy for weight loss. Am Diet Assoc. 2010;110(4):600–7.CrossRef Snyder-Marlow G, Taylor D, Lenhard J. Nutrition care for patients undergoing laparoscopic sleeve gastrectomy for weight loss. Am Diet Assoc. 2010;110(4):600–7.CrossRef
3.
go back to reference Roa P, Kaidar-Person O, Pinto D, et al. Laparoscopic sleeve gastrectomy as treatment for morbid obesity: technique and short-term outcome. Obes Surg. 2006;16:1323–6.CrossRefPubMed Roa P, Kaidar-Person O, Pinto D, et al. Laparoscopic sleeve gastrectomy as treatment for morbid obesity: technique and short-term outcome. Obes Surg. 2006;16:1323–6.CrossRefPubMed
4.
go back to reference Jacobs M, Bisland W, Gomez E, et al. Laparoscopic sleeve gastrectomy: a retrospective review of 1- and 2-year results. Surg Endosc. 2010;24:781–5.CrossRefPubMed Jacobs M, Bisland W, Gomez E, et al. Laparoscopic sleeve gastrectomy: a retrospective review of 1- and 2-year results. Surg Endosc. 2010;24:781–5.CrossRefPubMed
5.
go back to reference Lakdawala M, Bhasker A, Mulchandani D, et al. Comparison between the results of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass in the Indian population: a retrospective 1 year study. Obes Surg. 2010;20:1–6.CrossRefPubMed Lakdawala M, Bhasker A, Mulchandani D, et al. Comparison between the results of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass in the Indian population: a retrospective 1 year study. Obes Surg. 2010;20:1–6.CrossRefPubMed
6.
go back to reference Weiner R, Weiner S, Pomhoff I, et al. Laparoscopic sleeve gastrectomy—influence of sleeve size and resected gastric volume. Obes Surg. 2007;17:1297–305.CrossRefPubMed Weiner R, Weiner S, Pomhoff I, et al. Laparoscopic sleeve gastrectomy—influence of sleeve size and resected gastric volume. Obes Surg. 2007;17:1297–305.CrossRefPubMed
7.
go back to reference Melissas J, Koukouraki S, Askoxylakis J, et al. Sleeve gastrectomy: a restrictive procedure? Obes Surg. 2007;17(1):57–62.CrossRefPubMed Melissas J, Koukouraki S, Askoxylakis J, et al. Sleeve gastrectomy: a restrictive procedure? Obes Surg. 2007;17(1):57–62.CrossRefPubMed
8.
go back to reference Nocca D, Krawczykowsky D, Bomans B, et al. A prospective multicenter study of 163 sleeve gastrectomies: results at 1 and 2 years. Obesity Surgery. 2008;18:560–5.CrossRefPubMed Nocca D, Krawczykowsky D, Bomans B, et al. A prospective multicenter study of 163 sleeve gastrectomies: results at 1 and 2 years. Obesity Surgery. 2008;18:560–5.CrossRefPubMed
9.
go back to reference DuPree C, Blair K, Steele S, et al. Laparoscopic sleeve gastrectomy in patients with preexisting gastroesophageal reflux disease: a national analysis. JAMA Surgery. 2014;February:E1-7. DuPree C, Blair K, Steele S, et al. Laparoscopic sleeve gastrectomy in patients with preexisting gastroesophageal reflux disease: a national analysis. JAMA Surgery. 2014;February:E1-7.
10.
go back to reference Madalosso C, Gurski R, Callegari-Jacques S, et al. The impact of gastric bypass on gastroesophageal reflux disease in patients with morbid obesity. Ann Surg. 2010;251(2):244–8.CrossRefPubMed Madalosso C, Gurski R, Callegari-Jacques S, et al. The impact of gastric bypass on gastroesophageal reflux disease in patients with morbid obesity. Ann Surg. 2010;251(2):244–8.CrossRefPubMed
11.
go back to reference Sarkhosh K, Birch D, Sharma A, et al. Complications associated with laparoscopic sleeve gastrectomy for morbid obesity: a surgeon’s guide. Can J Surg. 2013;56(5):347–52.CrossRefPubMedCentralPubMed Sarkhosh K, Birch D, Sharma A, et al. Complications associated with laparoscopic sleeve gastrectomy for morbid obesity: a surgeon’s guide. Can J Surg. 2013;56(5):347–52.CrossRefPubMedCentralPubMed
12.
go back to reference Carabotti M, Silecchia G, Greco F, et al. Impact of laparoscopic sleeve gastrectomy on upper gastrointestinal symptoms. Obes Surg. 2013;23:1551–7.CrossRefPubMed Carabotti M, Silecchia G, Greco F, et al. Impact of laparoscopic sleeve gastrectomy on upper gastrointestinal symptoms. Obes Surg. 2013;23:1551–7.CrossRefPubMed
13.
go back to reference National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res. 1998;6(6):464.CrossRef National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res. 1998;6(6):464.CrossRef
14.
go back to reference Tuckman B. Selecting a statistical test in: conducting educational research. 5th ed. Wadsworth: Harcourt Brace College Publishers; 1999. p. Table 37.1. Tuckman B. Selecting a statistical test in: conducting educational research. 5th ed. Wadsworth: Harcourt Brace College Publishers; 1999. p. Table 37.1.
15.
go back to reference Braghetto I, Lanzarini E, Korn O, et al. Manometric changes of the lower esophageal sphincter after sleeve gastrectomy in obese patients. Obes Surg. 2010;20:357–62.CrossRefPubMed Braghetto I, Lanzarini E, Korn O, et al. Manometric changes of the lower esophageal sphincter after sleeve gastrectomy in obese patients. Obes Surg. 2010;20:357–62.CrossRefPubMed
16.
go back to reference Friedenberg F, Xanthopoulos M, Foster G, et al. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol. 2008;103(8):2111–22.CrossRefPubMed Friedenberg F, Xanthopoulos M, Foster G, et al. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol. 2008;103(8):2111–22.CrossRefPubMed
17.
go back to reference Carter P, LeBlanc K, Hausmann M, et al. Association between gastroesophageal reflux disease and laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2011;7:569–74.CrossRefPubMed Carter P, LeBlanc K, Hausmann M, et al. Association between gastroesophageal reflux disease and laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2011;7:569–74.CrossRefPubMed
18.
go back to reference Langer F, Hoda M, Bohdjalian A, et al. Sleeve gastrectomy and gastric banding: effects on plasma ghrelin levels. Obes Surg. 2005;15:1024–9.CrossRefPubMed Langer F, Hoda M, Bohdjalian A, et al. Sleeve gastrectomy and gastric banding: effects on plasma ghrelin levels. Obes Surg. 2005;15:1024–9.CrossRefPubMed
19.
go back to reference Katz P, Gerson L, Vela M. Diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–2.CrossRefPubMed Katz P, Gerson L, Vela M. Diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108:308–2.CrossRefPubMed
20.
go back to reference Akkary E, Duffy A, Bell R. Deciphering the sleeve: technique, indications, efficacy, and safety of sleeve gastrectomy. Obes Surg. 2008;18:1323–9.CrossRefPubMed Akkary E, Duffy A, Bell R. Deciphering the sleeve: technique, indications, efficacy, and safety of sleeve gastrectomy. Obes Surg. 2008;18:1323–9.CrossRefPubMed
21.
go back to reference Herbella F, Vicentine F, Del Grande J, et al. Postprandial proximal gastric acid pocket and gastric pressure in patients after gastric surgery. Neurogastroenterol Mot. 2011;23:52–e4.CrossRef Herbella F, Vicentine F, Del Grande J, et al. Postprandial proximal gastric acid pocket and gastric pressure in patients after gastric surgery. Neurogastroenterol Mot. 2011;23:52–e4.CrossRef
22.
go back to reference Roslin M. Comment on: association between gastroesophageal reflux disease and laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2011;7:572–4.CrossRefPubMed Roslin M. Comment on: association between gastroesophageal reflux disease and laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2011;7:572–4.CrossRefPubMed
23.
go back to reference Triantafyllidis G, Lazoura O, Sioka E, et al. Anatomy and complications following laparoscopic sleeve gastrectomy: radiological evaluation and imaging pitfalls. Obes Surg. 2011;21:473–8.CrossRefPubMed Triantafyllidis G, Lazoura O, Sioka E, et al. Anatomy and complications following laparoscopic sleeve gastrectomy: radiological evaluation and imaging pitfalls. Obes Surg. 2011;21:473–8.CrossRefPubMed
24.
go back to reference Jacques Himpens M, Giovanni Dapri M, Guy Bernard C. A prospective randomized study between laparoscopic gastric banding and laparoscopic isolated sleeve gastrectomy: results after 1 and 3 years. Obes Surg. 2006;16:1450–6.CrossRefPubMed Jacques Himpens M, Giovanni Dapri M, Guy Bernard C. A prospective randomized study between laparoscopic gastric banding and laparoscopic isolated sleeve gastrectomy: results after 1 and 3 years. Obes Surg. 2006;16:1450–6.CrossRefPubMed
25.
go back to reference Chiu S, Birch D, Shi X, et al. Effect of sleeve gastrectomy on gastroesophageal reflux disease: a systematic review. Surg Obes Relat Dis. 2011;7:510–5.CrossRefPubMed Chiu S, Birch D, Shi X, et al. Effect of sleeve gastrectomy on gastroesophageal reflux disease: a systematic review. Surg Obes Relat Dis. 2011;7:510–5.CrossRefPubMed
26.
go back to reference Cottam D, Qureshi F, Mattar S, et al. Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity. Surg Endosc. 2006;20:859–63.CrossRefPubMed Cottam D, Qureshi F, Mattar S, et al. Laparoscopic sleeve gastrectomy as an initial weight-loss procedure for high-risk patients with morbid obesity. Surg Endosc. 2006;20:859–63.CrossRefPubMed
27.
go back to reference Han S, Kim W, Oh J. Results of laparoscopic sleeve gastrectomy (LSG) at 1 year in morbidly obese Korean patients. Obes Surg. 2005;15:1469–75.CrossRef Han S, Kim W, Oh J. Results of laparoscopic sleeve gastrectomy (LSG) at 1 year in morbidly obese Korean patients. Obes Surg. 2005;15:1469–75.CrossRef
28.
go back to reference Parikh M, Issa R, McCrillis A, et al. Surgical strategies that may decrease leak after laparoscopic sleeve gastrectomy. Ann Surg. 2013;257(2):231–7.CrossRefPubMed Parikh M, Issa R, McCrillis A, et al. Surgical strategies that may decrease leak after laparoscopic sleeve gastrectomy. Ann Surg. 2013;257(2):231–7.CrossRefPubMed
29.
go back to reference Rosenthal R, International Sleeve Gastrectomy Expert Panel. International sleeve gastrectomy expert panel consensus statement: best practice guidelines based on experience of >12,000 cases. Surg Obes Relat Dis. 2012;8(1):8–19.CrossRefPubMed Rosenthal R, International Sleeve Gastrectomy Expert Panel. International sleeve gastrectomy expert panel consensus statement: best practice guidelines based on experience of >12,000 cases. Surg Obes Relat Dis. 2012;8(1):8–19.CrossRefPubMed
31.
go back to reference Bohdjalian A, Langer F, Shakeri-Leidenmuhler S, et al. Sleeve gastrectomy as sole and definitive bariatric procedure: 5-year results for weight loss and ghrelin. Obes Surg. 2010;20:535–40.CrossRefPubMed Bohdjalian A, Langer F, Shakeri-Leidenmuhler S, et al. Sleeve gastrectomy as sole and definitive bariatric procedure: 5-year results for weight loss and ghrelin. Obes Surg. 2010;20:535–40.CrossRefPubMed
32.
go back to reference Cremonini F, Ziogas D, Chang H, et al. Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease. Alimentary Pharmacol Therapy. 2010;32(1):29–42.CrossRef Cremonini F, Ziogas D, Chang H, et al. Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease. Alimentary Pharmacol Therapy. 2010;32(1):29–42.CrossRef
33.
go back to reference Del Genio G, Tolone S, Limongelli P, et al. Sleeve gastrectomy and development of “de novo” gastroesophageal reflux. Obes Surg. 2014;24(1):71–7.CrossRefPubMed Del Genio G, Tolone S, Limongelli P, et al. Sleeve gastrectomy and development of “de novo” gastroesophageal reflux. Obes Surg. 2014;24(1):71–7.CrossRefPubMed
34.
35.
go back to reference Deitel M, Gagner M, Erickson A, et al. Third international summit: current status of sleeve gastrectomy. Surg Obes Relat Dis. 2011;7:749–5.CrossRefPubMed Deitel M, Gagner M, Erickson A, et al. Third international summit: current status of sleeve gastrectomy. Surg Obes Relat Dis. 2011;7:749–5.CrossRefPubMed
36.
go back to reference Crookes P. Physiology of reflux disease: role of the lower esophageal sphincter. Surg Endosc. 2006;20:S462–6.CrossRefPubMed Crookes P. Physiology of reflux disease: role of the lower esophageal sphincter. Surg Endosc. 2006;20:S462–6.CrossRefPubMed
37.
go back to reference Jacobsen S, Olesen S, Dirksen C, et al. Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects. Obes Surg. 2012;22:1084–96.CrossRefPubMed Jacobsen S, Olesen S, Dirksen C, et al. Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects. Obes Surg. 2012;22:1084–96.CrossRefPubMed
38.
go back to reference Laffin M, Chau J, Gill R, et al. Sleeve gastrectomy and gastroesophageal reflux disease. J Obes. 2013;1–6. Laffin M, Chau J, Gill R, et al. Sleeve gastrectomy and gastroesophageal reflux disease. J Obes. 2013;1–6.
Metadata
Title
Rates of Reflux Before and After Laparoscopic Sleeve Gastrectomy for Severe Obesity
Authors
Caroline E. Sheppard
Daniel C. Sadowski
Christopher J. de Gara
Shahzeer Karmali
Daniel W. Birch
Publication date
01-05-2015
Publisher
Springer US
Published in
Obesity Surgery / Issue 5/2015
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-014-1480-y

Other articles of this Issue 5/2015

Obesity Surgery 5/2015 Go to the issue