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01-04-2012 | Clinical Research

Evolution of Lipid Profiles after Bariatric Surgery

Authors: Ignacio Garcia-Marirrodriga, Cesar Amaya-Romero, Gabriel Patiño Ruiz-Diaz, Sandra Férnandez, Carlos Ballesta-López, Jose Ma. Pou, June H. Romeo, Gemma Vilhur, Lina Badimon, Juan Ybarra

Published in: Obesity Surgery | Issue 4/2012

Abstract

Background

The most commonly encountered dyslipidemia in obese individuals is characterized by a cluster of interrelated plasma lipid and lipoprotein abnormalities including hypertriglyceridemia, low HDL cholesterol values, and increased small, dense LDL cholesterol particles. The aim of this study was to assess the changes in lipid profiles at baseline (pre-operatively) and at follow-up (6, 12, and 18 months) after a laparoscopic Roux-en-Y gastric bypass (LRYGBP). A retrospective observational study was performed involving all patients who consecutively underwent a LRYGBP between January 1, 2007 and December 31, 2009. Fasting lipids sub-fractions (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) were measured and HOMA-IR calculated pre-operatively and at follow-up post-LRYGBP. Pearson’s correlation coefficients were used to assess the relationship between excess weight loss (EWL) and lipid sub-fractions. ANOVA was used to assess the differences between each lipid sub-fraction at various time-points.

Methods

One hundred twenty eight (N = 128) medical charts were reviewed, and those containing data on lipid fractions at the three follow-up time-points were analyzed. One hundred fourteen patients (N = 114), 84 of whom were women (73.7%), were finally included in the study.

Results

Total cholesterol, LDL cholesterol, triglycerides, and HOMA-IR were significantly reduced after LRYGBP (P < 0.0005 for all). Inversely, HDL cholesterol disclosed a significant rise (P < 0.0005). Noteworthy significant associations between lipid subfractions and EWL were detected overall (P < 0.0005 for all). A gender effect was found since female patients displayed a milder association than male patients (P < 0.0005).

Conclusions

LRYGBP-induced weight loss improves the lipid profile while reducing insulin resistance, with male patients showing a better profile than female patients.

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Title: Evolution of Lipid Profiles after Bariatric Surgery
Authors: Ignacio Garcia-Marirrodriga
Cesar Amaya-Romero
Gabriel Patiño Ruiz-Diaz
Sandra Férnandez
Carlos Ballesta-López
Jose Ma. Pou
June H. Romeo
Gemma Vilhur
Lina Badimon
Juan Ybarra
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: Obesity Surgery / Issue 4/2012
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-011-0534-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Evolution of Lipid Profiles after Bariatric Surgery

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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