Skip to main content
Top
Published in: Journal of General Internal Medicine 8/2016

Open Access 01-08-2016 | Original Research

Does Motivation Matter? Analysis of a Randomized Trial of Proactive Outreach to VA Smokers

Authors: Elisheva R. Danan, MD, MPH, Anne M. Joseph, MD, MPH, Scott E. Sherman, MD, MPH, Diana J. Burgess, PhD, Siamak Noorbaloochi, PhD, Barbara Clothier, MS, Sandra J. Japuntich, PhD, Brent C. Taylor, PhD, Steven S. Fu, MD, MSCE

Published in: Journal of General Internal Medicine | Issue 8/2016

Login to get access

ABSTRACT

Background

Current guidelines advise providers to assess smokers’ readiness to quit, then offer cessation therapies to smokers planning to quit and motivational interventions to smokers not planning to quit.

Objectives

We examined the relationship between baseline stage of change (SOC), treatment utilization, and smoking cessation to determine whether the effect of a proactive smoking cessation intervention was dependent on smokers’ level of motivation to quit.

Design

Secondary analysis of a multicenter randomized controlled trial.

Participants

A total of 3006 current smokers, aged 18–80 years, at four Veterans Affairs (VA) medical centers.
Interventions: Proactive care included proactive outreach (mailed invitation followed by telephone outreach), offer of smoking cessation services (telephone or face-to-face), and access to pharmacotherapy. Usual care participants had access to VA smoking cessation services and state telephone quitlines.

Main Measures

Baseline SOC measured with Readiness to Quit Ladder, and 6-month prolonged abstinence self-reported at 1 year.

Key Results

At baseline, 35.8 % of smokers were in preparation, 38.2 % in contemplation, and 26.0 % in precontemplation. The overall interaction between SOC and treatment arm was not statistically significant (p = 0.30). Among smokers in preparation, 21.1 % of proactive care participants achieved 6-month prolonged abstinence, compared to 13.1 % of usual care participants (OR, 1.8 [95 % CI, 1.2–2.6]). Similarly, proactive care increased abstinence among smokers in contemplation (11.0 % vs. 6.5 %; OR, 1.8 [95 % CI, 1.1–2.8]). Smokers in precontemplation quit smoking at similar rates (5.3 % vs. 5.6 %; OR, 0.9 [95 % CI, 0.5–1.9]). Within each stage, uptake of smoking cessation treatments increased with higher SOC and with proactive care as compared with usual care.

Limitations

Mostly male participants limits generalizability. Randomization was not stratified by SOC.

Conclusions

Proactive care increased treatment uptake compared to usual care across all SOC. Proactive care increased smoking cessation among smokers in preparation and contemplation but not in precontemplation. Proactively offering cessation therapies to smokers at all SOC will increase treatment utilization and population-level smoking cessation.
Appendix
Available only for authorised users
Literature
1.
go back to reference Centers for Disease Control and Prevention. Quitting smoking among adults—United States 2001–2010. 2011:1513–1519. Centers for Disease Control and Prevention. Quitting smoking among adults—United States 2001–2010. 2011:1513–1519.
2.
go back to reference Centers for Disease Control and Prevention. Current Cigarette Smoking Among Adults—United States, 2005–2013. 2014:1108–1112. Centers for Disease Control and Prevention. Current Cigarette Smoking Among Adults—United States, 2005–2013. 2014:1108–1112.
3.
go back to reference Stead LF, Lancaster T. Combined pharmacotherapy and behavioural interventions for smoking cessation. Cochrane Database Syst Rev. 2012;10, CD008286.PubMed Stead LF, Lancaster T. Combined pharmacotherapy and behavioural interventions for smoking cessation. Cochrane Database Syst Rev. 2012;10, CD008286.PubMed
4.
go back to reference Kotz D, Brown J, West R. ‘Real-world’ effectiveness of smoking cessation treatments: a population study. Addiction. 2014;109(3):491–499.CrossRefPubMed Kotz D, Brown J, West R. ‘Real-world’ effectiveness of smoking cessation treatments: a population study. Addiction. 2014;109(3):491–499.CrossRefPubMed
5.
go back to reference Shiffman S, Brockwell SE, Pillitteri JL, Gitchell JG. Use of smoking-cessation treatments in the United States. Am J Prev Med. 2008;34(2):102–111.CrossRefPubMed Shiffman S, Brockwell SE, Pillitteri JL, Gitchell JG. Use of smoking-cessation treatments in the United States. Am J Prev Med. 2008;34(2):102–111.CrossRefPubMed
6.
go back to reference Fiore M, Jaen C, Baker T, Bailey W, Benowitz N, Curry S, et al. Treating Tobacco use and Dependence: 2008 Update. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service; 2008. Fiore M, Jaen C, Baker T, Bailey W, Benowitz N, Curry S, et al. Treating Tobacco use and Dependence: 2008 Update. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service; 2008.
7.
go back to reference Prochaska JO, DiClemente CC. Transtheoretical therapy: toward a more integrative model of change. Psychother Theory Res Pract Train. 1982;19:276–288.CrossRef Prochaska JO, DiClemente CC. Transtheoretical therapy: toward a more integrative model of change. Psychother Theory Res Pract Train. 1982;19:276–288.CrossRef
8.
go back to reference Spencer L, Pagell F, Hallion M, Adams T. Applying the transtheoretical model to tobacco cessation and prevention: a review of literature. Am J Health Promot. 2002;17(1):7–71.CrossRefPubMed Spencer L, Pagell F, Hallion M, Adams T. Applying the transtheoretical model to tobacco cessation and prevention: a review of literature. Am J Health Promot. 2002;17(1):7–71.CrossRefPubMed
9.
go back to reference Cahill K, Lancaster T, Green N. Stage-based interventions for smoking cessation. Cochrane Database Syst Rev. 2010;11, CD004492.PubMed Cahill K, Lancaster T, Green N. Stage-based interventions for smoking cessation. Cochrane Database Syst Rev. 2010;11, CD004492.PubMed
10.
go back to reference Prochaska JO, DiClemente CC. Stages and processes of self-change of smoking: toward an integrative model of change. J Consult Clin Psychol. 1983;51(3):390–395.CrossRefPubMed Prochaska JO, DiClemente CC. Stages and processes of self-change of smoking: toward an integrative model of change. J Consult Clin Psychol. 1983;51(3):390–395.CrossRefPubMed
11.
go back to reference DiClemente CC, Prochaska JO, Fairhurst SK, Velicer WF, Velasquez MM, Rossi JS. The process of smoking cessation: an analysis of precontemplation, contemplation, and preparation stages of change. J Consult Clin Psychol. 1991;59(2):295–304.CrossRefPubMed DiClemente CC, Prochaska JO, Fairhurst SK, Velicer WF, Velasquez MM, Rossi JS. The process of smoking cessation: an analysis of precontemplation, contemplation, and preparation stages of change. J Consult Clin Psychol. 1991;59(2):295–304.CrossRefPubMed
12.
go back to reference Prochaska JO. Flaws in the theory or flaws in the study: a commentary on "the effect of transtheoretical model based interventions on smoking cessation". Soc Sci Med. 2009;68(3):404–406.CrossRefPubMed Prochaska JO. Flaws in the theory or flaws in the study: a commentary on "the effect of transtheoretical model based interventions on smoking cessation". Soc Sci Med. 2009;68(3):404–406.CrossRefPubMed
13.
go back to reference Velicer WF, Fava JL, Prochaska JO, Abrams DB, Emmons KM, Pierce JP. Distribution of smokers by stage in three representative samples. Prev Med. 1995;24(4):401–411.CrossRefPubMed Velicer WF, Fava JL, Prochaska JO, Abrams DB, Emmons KM, Pierce JP. Distribution of smokers by stage in three representative samples. Prev Med. 1995;24(4):401–411.CrossRefPubMed
14.
go back to reference Etter JF, Perneger TV, Ronchi A. Distributions of smokers by stage: international comparison and association with smoking prevalence. Prev Med. 1997;26(4):580–585.CrossRefPubMed Etter JF, Perneger TV, Ronchi A. Distributions of smokers by stage: international comparison and association with smoking prevalence. Prev Med. 1997;26(4):580–585.CrossRefPubMed
15.
go back to reference Warner KE, Burns DM. Hardening and the hard-core smoker: concepts, evidence, and implications. Nicotine Tob Res. 2003;5(1):37–48.CrossRefPubMed Warner KE, Burns DM. Hardening and the hard-core smoker: concepts, evidence, and implications. Nicotine Tob Res. 2003;5(1):37–48.CrossRefPubMed
16.
go back to reference Wewers ME, Stillman FA, Hartman AM, Shopland DR. Distribution of daily smokers by stage of change: current population survey results. Prev Med. 2003;36(6):710–720.CrossRefPubMed Wewers ME, Stillman FA, Hartman AM, Shopland DR. Distribution of daily smokers by stage of change: current population survey results. Prev Med. 2003;36(6):710–720.CrossRefPubMed
17.
go back to reference ITC Project. ITC United States National Report. Findings from the Wave 1 to 8 Surveys (2002–2011). Waterloo (ON): University of Waterloo; and Charleston (SC): Medical University of South Carolina: 2014. ITC Project. ITC United States National Report. Findings from the Wave 1 to 8 Surveys (2002–2011). Waterloo (ON): University of Waterloo; and Charleston (SC): Medical University of South Carolina: 2014.
18.
go back to reference Lundahl BW, Kunz C, Brownell C, Tollefson D, Burke BL. A meta-analysis of motivational interviewing: twenty-five years of empirical studies. Res Soc Work Pract. 2010;20(2):137–160.CrossRef Lundahl BW, Kunz C, Brownell C, Tollefson D, Burke BL. A meta-analysis of motivational interviewing: twenty-five years of empirical studies. Res Soc Work Pract. 2010;20(2):137–160.CrossRef
19.
go back to reference Sciamanna C, Hoch J, Duke GC, Fogle M, Ford D. Comparison of five measures of motivation to quit smoking among a sample of hospitalized smokers. J Gen Intern Med. 2000;15(1):16–23.CrossRefPubMedPubMedCentral Sciamanna C, Hoch J, Duke GC, Fogle M, Ford D. Comparison of five measures of motivation to quit smoking among a sample of hospitalized smokers. J Gen Intern Med. 2000;15(1):16–23.CrossRefPubMedPubMedCentral
20.
go back to reference Herzog TA, Abrams DB, Emmons KM, Linnan L. Predicting increases in readiness to quit smoking: a prospective analysis using the contemplation ladder. Psychol Health. 2000;15(3):369–381.CrossRef Herzog TA, Abrams DB, Emmons KM, Linnan L. Predicting increases in readiness to quit smoking: a prospective analysis using the contemplation ladder. Psychol Health. 2000;15(3):369–381.CrossRef
21.
go back to reference Etter JF, Sutton S. Assessing ‘stage of change’ in current and former smokers. Addiction. 2002;97:1171–1182.CrossRefPubMed Etter JF, Sutton S. Assessing ‘stage of change’ in current and former smokers. Addiction. 2002;97:1171–1182.CrossRefPubMed
22.
go back to reference Herzog TA, Blagg CO. Are most precontemplators contemplating smoking cessation? Assessing the validity of the stages of change. Health Psychol. 2007;26(2):222–231.CrossRefPubMed Herzog TA, Blagg CO. Are most precontemplators contemplating smoking cessation? Assessing the validity of the stages of change. Health Psychol. 2007;26(2):222–231.CrossRefPubMed
23.
go back to reference Pisinger C, Vestbo J, Borch-Johnsen K, Jorgensen T. It is possible to help smokers in early motivational stages to quit. The Inter99 study. Prev Med. 2005;40(3):278–284.PubMed Pisinger C, Vestbo J, Borch-Johnsen K, Jorgensen T. It is possible to help smokers in early motivational stages to quit. The Inter99 study. Prev Med. 2005;40(3):278–284.PubMed
24.
go back to reference Tzelepis F, Paul CL, Walsh RA, Wiggers J, Duncan SL, Knight J. Predictors of abstinence among smokers recruited actively to quitline support. Addiction. 2013;108(1):181–185.CrossRefPubMed Tzelepis F, Paul CL, Walsh RA, Wiggers J, Duncan SL, Knight J. Predictors of abstinence among smokers recruited actively to quitline support. Addiction. 2013;108(1):181–185.CrossRefPubMed
25.
go back to reference Curry S, McBride C, Grothaus L, Louie D, Wagner E. A randomized trial of self-help materials, personalized feedback, and telephone counseling with nonvolunteer smokers. J Consult Clin Psychol. 1995;63(6):1005–1014.CrossRefPubMed Curry S, McBride C, Grothaus L, Louie D, Wagner E. A randomized trial of self-help materials, personalized feedback, and telephone counseling with nonvolunteer smokers. J Consult Clin Psychol. 1995;63(6):1005–1014.CrossRefPubMed
26.
go back to reference West R. Time for a change: putting the transtheoretical (stages of change) model to rest. Addiction. 2005;100(8):1036–1039.CrossRefPubMed West R. Time for a change: putting the transtheoretical (stages of change) model to rest. Addiction. 2005;100(8):1036–1039.CrossRefPubMed
27.
go back to reference Kraft P, Sutton S, Reynolds H. The transtheoretical model of behavior change: are the stages qualitatively different? Psychol Health. 1999;14:433–450.CrossRef Kraft P, Sutton S, Reynolds H. The transtheoretical model of behavior change: are the stages qualitatively different? Psychol Health. 1999;14:433–450.CrossRef
28.
go back to reference Herzog TA. Analyzing the transtheoretical model using the framework of Weinstein, Rothman, and Sutton (1998): the example of smoking cessation. Health Psychol. 2008;27(5):548–556.CrossRefPubMed Herzog TA. Analyzing the transtheoretical model using the framework of Weinstein, Rothman, and Sutton (1998): the example of smoking cessation. Health Psychol. 2008;27(5):548–556.CrossRefPubMed
29.
go back to reference Hughes JR, Keely JP, Fagerstrom KO, Callas PW. Intentions to quit smoking change over short periods of time. Addict Behav. 2005;30(4):653–662.CrossRefPubMed Hughes JR, Keely JP, Fagerstrom KO, Callas PW. Intentions to quit smoking change over short periods of time. Addict Behav. 2005;30(4):653–662.CrossRefPubMed
30.
go back to reference Aveyard P, Begh R, Parsons A, West R. Brief opportunistic smoking cessation interventions: a systematic review and meta-analysis to compare advice to quit and offer of assistance. Addiction. 2012;107:1066–1073.CrossRefPubMed Aveyard P, Begh R, Parsons A, West R. Brief opportunistic smoking cessation interventions: a systematic review and meta-analysis to compare advice to quit and offer of assistance. Addiction. 2012;107:1066–1073.CrossRefPubMed
31.
go back to reference Fu SS, van Ryn M, Sherman SE. Proactive tobacco treatment and population-level cessation: a pragmatic randomized clinical trial. JAMA Intern Med. 2014;174(5):671–677.CrossRefPubMed Fu SS, van Ryn M, Sherman SE. Proactive tobacco treatment and population-level cessation: a pragmatic randomized clinical trial. JAMA Intern Med. 2014;174(5):671–677.CrossRefPubMed
32.
go back to reference Fu SS, van Ryn M, Sherman SE, Burgess DJ, Noorbaloochi S, Clothier B, et al. Population-based tobacco treatment: study design of a randomized controlled trial. BMC Public Health. 2012;12:159.CrossRefPubMedPubMedCentral Fu SS, van Ryn M, Sherman SE, Burgess DJ, Noorbaloochi S, Clothier B, et al. Population-based tobacco treatment: study design of a randomized controlled trial. BMC Public Health. 2012;12:159.CrossRefPubMedPubMedCentral
33.
go back to reference Chabrol H, Niezborala M, Chastan E, de Leon J. Comparison of the heavy smoking index and of the fagerstrom test for nicotine dependence in a sample of 749 cigarette smokers. Addict Behav. 2005;30(7):1474–1477.CrossRefPubMed Chabrol H, Niezborala M, Chastan E, de Leon J. Comparison of the heavy smoking index and of the fagerstrom test for nicotine dependence in a sample of 749 cigarette smokers. Addict Behav. 2005;30(7):1474–1477.CrossRefPubMed
34.
go back to reference Abrams DB, Niaura R, Brown RA, Emmons KM, Goldstein MG, Monti PM. The Tobacco Dependence Treatment Handbook: A Guide to Best Practices. New York: The Guilford Press; 2003. Abrams DB, Niaura R, Brown RA, Emmons KM, Goldstein MG, Monti PM. The Tobacco Dependence Treatment Handbook: A Guide to Best Practices. New York: The Guilford Press; 2003.
35.
go back to reference Ibrahim J, Chen M, Lipsitz S. Missing responses in generalised linear mixed models when the missing data mechanism is nonignorable. Biometrika. 2001;88(2):551–564.CrossRef Ibrahim J, Chen M, Lipsitz S. Missing responses in generalised linear mixed models when the missing data mechanism is nonignorable. Biometrika. 2001;88(2):551–564.CrossRef
36.
go back to reference Fleiss JL, Levin B, Paik MC. Statistical Methods for Rates and Proportions. 3rd ed. New Jersey: Wiley; 2003.CrossRef Fleiss JL, Levin B, Paik MC. Statistical Methods for Rates and Proportions. 3rd ed. New Jersey: Wiley; 2003.CrossRef
37.
go back to reference Tzelepis F, Paul CL, Walsh RA, McElduff P, Knight J. Proactive telephone counseling for smoking cessation: meta-analyses by recruitment channel and methodological quality. J Natl Cancer Inst. 2011;103(12):922–941.CrossRefPubMed Tzelepis F, Paul CL, Walsh RA, McElduff P, Knight J. Proactive telephone counseling for smoking cessation: meta-analyses by recruitment channel and methodological quality. J Natl Cancer Inst. 2011;103(12):922–941.CrossRefPubMed
38.
go back to reference Vangeli E, Stapleton J, Smit ES, Borland R, West R. Predictors of attempts to stop smoking and their success in adult general population samples: a systematic review. Addiction. 2011;106(12):2110–2121.CrossRefPubMed Vangeli E, Stapleton J, Smit ES, Borland R, West R. Predictors of attempts to stop smoking and their success in adult general population samples: a systematic review. Addiction. 2011;106(12):2110–2121.CrossRefPubMed
39.
go back to reference Hyland A, Borland R, Li Q, Yong HH, McNeill A, Fong GT, et al. Individual-level predictors of cessation behaviours among participants in the international tobacco control (ITC) four country survey. Tob Control. 2006;15(Suppl 3):iii83–iii94.PubMedPubMedCentral Hyland A, Borland R, Li Q, Yong HH, McNeill A, Fong GT, et al. Individual-level predictors of cessation behaviours among participants in the international tobacco control (ITC) four country survey. Tob Control. 2006;15(Suppl 3):iii83–iii94.PubMedPubMedCentral
40.
go back to reference Dijkstra A, De VH. Subtypes of precontemplating smokers defined by different long-term plans to change their smoking behavior. Health Educ Res. 2000;15(4):423–434.CrossRefPubMed Dijkstra A, De VH. Subtypes of precontemplating smokers defined by different long-term plans to change their smoking behavior. Health Educ Res. 2000;15(4):423–434.CrossRefPubMed
41.
go back to reference Tzelepis F, Paul CL, Wiggers J, Walsh RA, Knight J, Duncan SL, et al. A randomised controlled trial of proactive telephone counselling on cold-called smokers' cessation rates. Tob Control. 2011;20(1):40–46.CrossRefPubMed Tzelepis F, Paul CL, Wiggers J, Walsh RA, Knight J, Duncan SL, et al. A randomised controlled trial of proactive telephone counselling on cold-called smokers' cessation rates. Tob Control. 2011;20(1):40–46.CrossRefPubMed
42.
go back to reference Stead LF, Hartmann-Boyce J, Perera R, Lancaster T. Telephone counselling for smoking cessation. Cochrane Database Syst Rev. 2013;8, CD002850.PubMed Stead LF, Hartmann-Boyce J, Perera R, Lancaster T. Telephone counselling for smoking cessation. Cochrane Database Syst Rev. 2013;8, CD002850.PubMed
43.
go back to reference Haas JS, Linder JA, Park ER. Proactive tobacco cessation outreach to smokers of low socioeconomic status: a randomized clinical trial. JAMA Intern Med. 2015;175(2):218–226.CrossRefPubMedPubMedCentral Haas JS, Linder JA, Park ER. Proactive tobacco cessation outreach to smokers of low socioeconomic status: a randomized clinical trial. JAMA Intern Med. 2015;175(2):218–226.CrossRefPubMedPubMedCentral
44.
go back to reference Pisinger C, Vestbo J, Borch-Johnsen K, Thomsen T, Jorgensen T. Acceptance of the smoking cessation intervention in a large population-based study: The Inter99 study. Scand J Public Health. 2005;33(2):138–145.CrossRefPubMed Pisinger C, Vestbo J, Borch-Johnsen K, Thomsen T, Jorgensen T. Acceptance of the smoking cessation intervention in a large population-based study: The Inter99 study. Scand J Public Health. 2005;33(2):138–145.CrossRefPubMed
45.
go back to reference Richter KP, Ellerbeck EF. It's time to change the default for tobacco treatment. Addiction. 2015;110(3):381–386.CrossRefPubMed Richter KP, Ellerbeck EF. It's time to change the default for tobacco treatment. Addiction. 2015;110(3):381–386.CrossRefPubMed
46.
go back to reference Brown C. Chaos and Catastrophic Theories: Quantitative Applications in the Social Sciences. London: Sage; 1995.CrossRef Brown C. Chaos and Catastrophic Theories: Quantitative Applications in the Social Sciences. London: Sage; 1995.CrossRef
48.
go back to reference Carpenter MJ, Hughes JR, Gray KM, Wahlquist AE, Saladin ME, Alberg AJ. Nicotine therapy sampling to induce quit attempts among smokers unmotivated to quit: a randomized clinical trial. Arch Intern Med. 2011;171(21):1901–1907.CrossRefPubMedPubMedCentral Carpenter MJ, Hughes JR, Gray KM, Wahlquist AE, Saladin ME, Alberg AJ. Nicotine therapy sampling to induce quit attempts among smokers unmotivated to quit: a randomized clinical trial. Arch Intern Med. 2011;171(21):1901–1907.CrossRefPubMedPubMedCentral
49.
go back to reference Cropsey KL, Hendricks PS, Jardin B, Clark CB, Katiyar N, Willig J, et al. A pilot study of screening, brief intervention, and referral for treatment (SBIRT) in non-treatment seeking smokers with HIV. Addict Behav. 2013;38(10):2541–2546.CrossRefPubMedPubMedCentral Cropsey KL, Hendricks PS, Jardin B, Clark CB, Katiyar N, Willig J, et al. A pilot study of screening, brief intervention, and referral for treatment (SBIRT) in non-treatment seeking smokers with HIV. Addict Behav. 2013;38(10):2541–2546.CrossRefPubMedPubMedCentral
50.
go back to reference Jardin BF, Cropsey KL, Wahlquist AE, Gray KM, Silvestri GA, Cummings KM, et al. Evaluating the effect of access to free medication to quit smoking: a clinical trial testing the role of motivation. Nicotine Tob Res. 2014;16(7):992–999.CrossRefPubMedPubMedCentral Jardin BF, Cropsey KL, Wahlquist AE, Gray KM, Silvestri GA, Cummings KM, et al. Evaluating the effect of access to free medication to quit smoking: a clinical trial testing the role of motivation. Nicotine Tob Res. 2014;16(7):992–999.CrossRefPubMedPubMedCentral
Metadata
Title
Does Motivation Matter? Analysis of a Randomized Trial of Proactive Outreach to VA Smokers
Authors
Elisheva R. Danan, MD, MPH
Anne M. Joseph, MD, MPH
Scott E. Sherman, MD, MPH
Diana J. Burgess, PhD
Siamak Noorbaloochi, PhD
Barbara Clothier, MS
Sandra J. Japuntich, PhD
Brent C. Taylor, PhD
Steven S. Fu, MD, MSCE
Publication date
01-08-2016
Publisher
Springer US
Published in
Journal of General Internal Medicine / Issue 8/2016
Print ISSN: 0884-8734
Electronic ISSN: 1525-1497
DOI
https://doi.org/10.1007/s11606-016-3687-1

Other articles of this Issue 8/2016

Journal of General Internal Medicine 8/2016 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine