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Journal of Gastrointestinal Surgery

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Open Access 01-05-2016 | Original Article

Long-Term Survival After Complications Following Major Abdominal Surgery

Authors: Jennifer Straatman, Miguel A. Cuesta, Elly S. M. de Lange – de Klerk, Donald L. van der Peet

Published in: Journal of Gastrointestinal Surgery | Issue 5/2016

Abstract

Introduction

Postoperative complications have been associated with decreased long-term survival in cardiac, orthopedic, and vascular surgery. For major abdominal surgery research, conflicting evidence is reported in smaller studies. The aim of this study was to assess the effect of complications on long-term survival in major abdominal surgery.

Material and Methods

An observational cohort study was conducted of 861 consecutive patients that underwent major abdominal surgery between January 2009 and March 2014, with prospective assessment of the survival status. The effect of postoperative complications on survival was assessed.

Results

Postoperative complications were associated with decreased survival, even after applying correction for 30-day mortality (p < 0.001). Stratified Cox regression analysis depicted postoperative complications to be an important predictor for survival in upper gastrointestinal and female hepatopancreaticobiliary patients. Correction was applied for age, gender, BMI, ASA classification, radicality, and positive lymph node status.

Conclusion

These results further indicate the importance of prevention and early diagnosis and treatment of complications. Etiological factors are believed to be both sustained levels of inflammatory markers, as well as attenuated immune response in malignancy with subsequent cancer cell seeding. Future research should aim to prevent and early diagnose postoperative complications to prevent morbidity and mortality not only in the early postoperative phase, but also in the long term.

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Title: Long-Term Survival After Complications Following Major Abdominal Surgery
Authors: Jennifer Straatman
Miguel A. Cuesta
Elly S. M. de Lange – de Klerk
Donald L. van der Peet
Publication date: 01-05-2016
Publisher: Springer US
Published in: Journal of Gastrointestinal Surgery / Issue 5/2016
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-016-3084-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Long-Term Survival After Complications Following Major Abdominal Surgery

Abstract

Introduction

Material and Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Material and Methods

Results

Conclusion

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