Skip to main content
Top
Published in: Journal of Gastrointestinal Surgery 9/2015

01-09-2015 | Original Article

Postoperative Ileus—More than Just Prolonged Length of Stay?

Authors: Sarah E. Tevis, Evie H. Carchman, Eugene F. Foley, Bruce A. Harms, Charles P. Heise, Gregory D. Kennedy

Published in: Journal of Gastrointestinal Surgery | Issue 9/2015

Login to get access

Abstract

Purpose

Given that postoperative ileus is common in colectomy patients, we sought to examine the association of ileus with adverse events in this patient population.

Methods

The ACS NSQIP puf file from 2012 to 2013 was queried for non-emergent colectomy cases. Predictors of other poor postoperative outcomes in patients who experienced postoperative ileus were assessed using chi-squared and multivariable regression analyses. Chi-squared analysis was used to assess for additive effects of ileus and other postoperative complications on mortality. p Values <0.05 were considered significant.

Results

We identified 32,392 patients who underwent non-emergent colectomy. Longer length of stay, higher complication, reoperation, readmission, and mortality rates were identified in patients with ileus (p < 0.001 for all). Overall, 59 % of patients with ileus had at least one adverse outcome, compared with 25 % of patients without ileus (p < 0.001). Patients who developed ileus in the absence of other complications had an identical mortality rate to patients without ileus (1 %). Additional complications led to incremental increases in mortality rates.

Conclusions

Patients with ileus and multiple complications are at significantly increased risk for adverse outcomes. Older patients with more comorbidity were found to be at risk for adverse outcomes in addition to ileus, begging the question of whether these patients may benefit from preoperative optimization.
Literature
1.
go back to reference van Bree, S.H., W.A. Bemelman, M.W. Hollmann, A.H. Zwinderman, G. Matteoli, S. El Temna, F.O. The, M.S. Vlug, R.J. Bennink, and G.E. Boeckxstaens, Identification of clinical outcome measures for recovery of gastrointestinal motility in postoperative ileus. Ann Surg, 2014. 259(4): p. 708–14.CrossRefPubMed van Bree, S.H., W.A. Bemelman, M.W. Hollmann, A.H. Zwinderman, G. Matteoli, S. El Temna, F.O. The, M.S. Vlug, R.J. Bennink, and G.E. Boeckxstaens, Identification of clinical outcome measures for recovery of gastrointestinal motility in postoperative ileus. Ann Surg, 2014. 259(4): p. 708–14.CrossRefPubMed
2.
go back to reference Asgeirsson, T., K.I. El-Badawi, A. Mahmood, J. Barletta, M. Luchtefeld, and A.J. Senagore, Postoperative ileus: it costs more than you expect. J Am Coll Surg, 2010. 210(2): p. 228–31.CrossRefPubMed Asgeirsson, T., K.I. El-Badawi, A. Mahmood, J. Barletta, M. Luchtefeld, and A.J. Senagore, Postoperative ileus: it costs more than you expect. J Am Coll Surg, 2010. 210(2): p. 228–31.CrossRefPubMed
3.
go back to reference Chapuis, P.H., L. Bokey, A. Keshava, M.J. Rickard, P. Stewart, C.J. Young, and O.F. Dent, Risk factors for prolonged ileus after resection of colorectal cancer: an observational study of 2400 consecutive patients. Ann Surg, 2013. 257(5): p. 909–15.CrossRefPubMed Chapuis, P.H., L. Bokey, A. Keshava, M.J. Rickard, P. Stewart, C.J. Young, and O.F. Dent, Risk factors for prolonged ileus after resection of colorectal cancer: an observational study of 2400 consecutive patients. Ann Surg, 2013. 257(5): p. 909–15.CrossRefPubMed
4.
go back to reference Kronberg, U., R.P. Kiran, M.S. Soliman, J.P. Hammel, U. Galway, J.C. Coffey, and V.W. Fazio, A characterization of factors determining postoperative ileus after laparoscopic colectomy enables the generation of a novel predictive score. Ann Surg, 2011. 253(1): p. 78–81.CrossRefPubMed Kronberg, U., R.P. Kiran, M.S. Soliman, J.P. Hammel, U. Galway, J.C. Coffey, and V.W. Fazio, A characterization of factors determining postoperative ileus after laparoscopic colectomy enables the generation of a novel predictive score. Ann Surg, 2011. 253(1): p. 78–81.CrossRefPubMed
5.
go back to reference Millan, M., S. Biondo, D. Fraccalvieri, R. Frago, T. Golda, and E. Kreisler, Risk factors for prolonged postoperative ileus after colorectal cancer surgery. World J Surg, 2012. 36(1): p. 179–85.CrossRefPubMed Millan, M., S. Biondo, D. Fraccalvieri, R. Frago, T. Golda, and E. Kreisler, Risk factors for prolonged postoperative ileus after colorectal cancer surgery. World J Surg, 2012. 36(1): p. 179–85.CrossRefPubMed
6.
go back to reference Sindell, S., M.W. Causey, T. Bradley, M. Poss, R. Moonka, and R. Thirlby, Expediting return of bowel function after colorectal surgery. Am J Surg, 2012. 203(5): p. 644–8.CrossRefPubMed Sindell, S., M.W. Causey, T. Bradley, M. Poss, R. Moonka, and R. Thirlby, Expediting return of bowel function after colorectal surgery. Am J Surg, 2012. 203(5): p. 644–8.CrossRefPubMed
7.
go back to reference Lovely, J.K., P.M. Maxson, A.K. Jacob, R.R. Cima, T.T. Horlocker, J.R. Hebl, W.S. Harmsen, M. Huebner, and D.W. Larson, Case-matched series of enhanced versus standard recovery pathway in minimally invasive colorectal surgery. Br J Surg, 2012. 99(1): p. 120–6.CrossRefPubMed Lovely, J.K., P.M. Maxson, A.K. Jacob, R.R. Cima, T.T. Horlocker, J.R. Hebl, W.S. Harmsen, M. Huebner, and D.W. Larson, Case-matched series of enhanced versus standard recovery pathway in minimally invasive colorectal surgery. Br J Surg, 2012. 99(1): p. 120–6.CrossRefPubMed
8.
go back to reference Nygren, J., M. Soop, A. Thorell, J. Hausel, O. Ljungqvist, and E. Group, An enhanced-recovery protocol improves outcome after colorectal resection already during the first year: a single-center experience in 168 consecutive patients. Dis Colon Rectum, 2009. 52(5): p. 978–85.CrossRefPubMed Nygren, J., M. Soop, A. Thorell, J. Hausel, O. Ljungqvist, and E. Group, An enhanced-recovery protocol improves outcome after colorectal resection already during the first year: a single-center experience in 168 consecutive patients. Dis Colon Rectum, 2009. 52(5): p. 978–85.CrossRefPubMed
9.
go back to reference Morris, M.S., L.A. Graham, D.I. Chu, J.A. Cannon, and M.T. Hawn, Oral Antibiotic Bowel Preparation Significantly Reduces Surgical Site Infection Rates and Readmission Rates in Elective Colorectal Surgery. Ann Surg, 2015. Morris, M.S., L.A. Graham, D.I. Chu, J.A. Cannon, and M.T. Hawn, Oral Antibiotic Bowel Preparation Significantly Reduces Surgical Site Infection Rates and Readmission Rates in Elective Colorectal Surgery. Ann Surg, 2015.
10.
go back to reference Toneva, G.D., R.J. Deierhoi, M. Morris, J. Richman, J.A. Cannon, L.K. Altom, and M.T. Hawn, Oral antibiotic bowel preparation reduces length of stay and readmissions after colorectal surgery. J Am Coll Surg, 2013. 216(4): p. 756–62; discussion 762–3.CrossRefPubMed Toneva, G.D., R.J. Deierhoi, M. Morris, J. Richman, J.A. Cannon, L.K. Altom, and M.T. Hawn, Oral antibiotic bowel preparation reduces length of stay and readmissions after colorectal surgery. J Am Coll Surg, 2013. 216(4): p. 756–62; discussion 762–3.CrossRefPubMed
11.
go back to reference Farhat, J.S., V. Velanovich, A.J. Falvo, H.M. Horst, A. Swartz, J.H. Patton, Jr., and I.S. Rubinfeld, Are the frail destined to fail? Frailty index as predictor of surgical morbidity and mortality in the elderly. J Trauma Acute Care Surg, 2012. 72(6): p. 1526–30; discussion 1530–1.CrossRefPubMed Farhat, J.S., V. Velanovich, A.J. Falvo, H.M. Horst, A. Swartz, J.H. Patton, Jr., and I.S. Rubinfeld, Are the frail destined to fail? Frailty index as predictor of surgical morbidity and mortality in the elderly. J Trauma Acute Care Surg, 2012. 72(6): p. 1526–30; discussion 1530–1.CrossRefPubMed
12.
go back to reference Ehlenbach, C.C., S.E. Tevis, G.D. Kennedy, and S.C. Oltmann, Preoperative impairment is associated with a higher postdischarge level of care. J Surg Res, 2015. 193(1): p. 1–6.CrossRefPubMed Ehlenbach, C.C., S.E. Tevis, G.D. Kennedy, and S.C. Oltmann, Preoperative impairment is associated with a higher postdischarge level of care. J Surg Res, 2015. 193(1): p. 1–6.CrossRefPubMed
13.
go back to reference Robinson, T.N., D.S. Wu, L.F. Pointer, C.L. Dunn, and M. Moss, Preoperative cognitive dysfunction is related to adverse postoperative outcomes in the elderly. J Am Coll Surg, 2012. 215(1): p. 12–7; discussion 17–8.PubMedCentralCrossRefPubMed Robinson, T.N., D.S. Wu, L.F. Pointer, C.L. Dunn, and M. Moss, Preoperative cognitive dysfunction is related to adverse postoperative outcomes in the elderly. J Am Coll Surg, 2012. 215(1): p. 12–7; discussion 17–8.PubMedCentralCrossRefPubMed
14.
go back to reference Carli, F. and C. Scheede-Bergdahl, Prehabilitation to enhance perioperative care. Anesthesiol Clin, 2015. 33(1): p. 17–33.CrossRefPubMed Carli, F. and C. Scheede-Bergdahl, Prehabilitation to enhance perioperative care. Anesthesiol Clin, 2015. 33(1): p. 17–33.CrossRefPubMed
15.
go back to reference Li, S., Y. Liu, Q. Peng, L. Xie, J. Wang, and X. Qin, Chewing gum reduces postoperative ileus following abdominal surgery: a meta-analysis of 17 randomized controlled trials. J Gastroenterol Hepatol, 2013. 28(7): p. 1122–32.CrossRefPubMed Li, S., Y. Liu, Q. Peng, L. Xie, J. Wang, and X. Qin, Chewing gum reduces postoperative ileus following abdominal surgery: a meta-analysis of 17 randomized controlled trials. J Gastroenterol Hepatol, 2013. 28(7): p. 1122–32.CrossRefPubMed
16.
go back to reference Muller, S.A., N.N. Rahbari, B.M. Schmied, and M.W. Buchler, Can postoperative coffee perk up recovery time after colon surgery? Expert Rev Gastroenterol Hepatol, 2013. 7(2): p. 91–3.CrossRefPubMed Muller, S.A., N.N. Rahbari, B.M. Schmied, and M.W. Buchler, Can postoperative coffee perk up recovery time after colon surgery? Expert Rev Gastroenterol Hepatol, 2013. 7(2): p. 91–3.CrossRefPubMed
17.
go back to reference Traut, U., L. Brugger, R. Kunz, C. Pauli-Magnus, K. Haug, H.C. Bucher, and M.T. Koller, Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus following abdominal surgery in adults. Cochrane Database Syst Rev, 2008(1): p. CD004930.PubMed Traut, U., L. Brugger, R. Kunz, C. Pauli-Magnus, K. Haug, H.C. Bucher, and M.T. Koller, Systemic prokinetic pharmacologic treatment for postoperative adynamic ileus following abdominal surgery in adults. Cochrane Database Syst Rev, 2008(1): p. CD004930.PubMed
18.
go back to reference Ferraris, V.A., M. Bolanos, J.T. Martin, A. Mahan, and S.P. Saha, Identification of patients with postoperative complications who are at risk for failure to rescue. JAMA Surg, 2014. 149(11): p. 1103–8.CrossRefPubMed Ferraris, V.A., M. Bolanos, J.T. Martin, A. Mahan, and S.P. Saha, Identification of patients with postoperative complications who are at risk for failure to rescue. JAMA Surg, 2014. 149(11): p. 1103–8.CrossRefPubMed
19.
go back to reference Boltz, M.M., C.S. Hollenbeak, G. Ortenzi, and P.W. Dillon, Synergistic implications of multiple postoperative outcomes. Am J Med Qual, 2012. 27(5): p. 383–90.CrossRefPubMed Boltz, M.M., C.S. Hollenbeak, G. Ortenzi, and P.W. Dillon, Synergistic implications of multiple postoperative outcomes. Am J Med Qual, 2012. 27(5): p. 383–90.CrossRefPubMed
Metadata
Title
Postoperative Ileus—More than Just Prolonged Length of Stay?
Authors
Sarah E. Tevis
Evie H. Carchman
Eugene F. Foley
Bruce A. Harms
Charles P. Heise
Gregory D. Kennedy
Publication date
01-09-2015
Publisher
Springer US
Published in
Journal of Gastrointestinal Surgery / Issue 9/2015
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-015-2877-1

Other articles of this Issue 9/2015

Journal of Gastrointestinal Surgery 9/2015 Go to the issue