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01-09-2011 | Case Report

The Novel Triad of Dorsal Agenesis of the Pancreas with Concurrent Pancreatic Ductal Adenocarcinoma and Nonalcoholic Chronic Calcific Pancreatitis: A Case Series and Review of the Literature

Authors: David W. Rittenhouse, Eugene P. Kennedy, Andres A. Mascaro, Jennifer L. Brumbaugh, Louis H. Stein, Laura H. Rosenberger, Patricia K. Sauter, Charles J. Yeo, Harish Lavu

Published in: Journal of Gastrointestinal Surgery | Issue 9/2011

Abstract

Introduction

Dorsal agenesis of the pancreas (DAP) is a rare congenital anomaly, with only 44 cases having been reported in the English literature since 1966.

Materials and Methods

A retrospective review of our IRB-approved pancreatic surgery database was performed from November 2005 to November 2010 searching for cases of DAP.

Discussion

Disorders in the retinoic acid (Raldh) and hedgehog (Hh) signaling pathways, which appear to play a role in the development of DAP, have been implicated in other diseases of the pancreas such as pancreatic ductal adenocarcinoma (PDA) and nonalcoholic chronic calcific pancreatitis (NCCP).

Conclusion

In this report, we describe three cases of DAP in the setting of PDA, two of which include the third component of NCCP. We provide a discussion of the clinical features of this novel triad and address the molecular pathways that relate to these respective diseases.

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Title: The Novel Triad of Dorsal Agenesis of the Pancreas with Concurrent Pancreatic Ductal Adenocarcinoma and Nonalcoholic Chronic Calcific Pancreatitis: A Case Series and Review of the Literature
Authors: David W. Rittenhouse
Eugene P. Kennedy
Andres A. Mascaro
Jennifer L. Brumbaugh
Louis H. Stein
Laura H. Rosenberger
Patricia K. Sauter
Charles J. Yeo
Harish Lavu
Publication date: 01-09-2011
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 9/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-011-1542-6

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The Novel Triad of Dorsal Agenesis of the Pancreas with Concurrent Pancreatic Ductal Adenocarcinoma and Nonalcoholic Chronic Calcific Pancreatitis: A Case Series and Review of the Literature

Abstract

Introduction

Materials and Methods

Discussion

Conclusion

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Abstract

Introduction

Materials and Methods

Discussion

Conclusion

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