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Published in: Journal of Gastrointestinal Surgery 6/2011

01-06-2011 | Original Article

Initial Experience with Transanal Endoscopic Microsurgery: the Need for Understanding the Limitations

Authors: Emily Steinhagen, Gerard Chang, José G. Guillem

Published in: Journal of Gastrointestinal Surgery | Issue 6/2011

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Abstract

Introduction

Transanal endoscopic microsurgery is an alternative to transanal excision or radical surgery for benign and carefully selected malignant rectal tumors. Advantages over transanal excision include better visualization, access to more proximal lesions, higher likelihood of negative margins, and lower recurrence rates. Compared to radical resection, patients experience lower rates of morbidity and mortality but may have higher rates of local recurrence.

Methods

A review of a prospectively maintained database of patients scheduled for transanal endoscopic microsurgery was performed.

Results

Ninety-three patients underwent 96 procedures for 13 carcinoid tumors, 1 submucosal mass, 46 adenomas, 12 in situ adenocarcinomas, and 21 invasive adenocarcinomas. Of these cases, 81.2% was successfully completed. There were nine complications (11.5%). Final pathology demonstrated 33 in situ and invasive adenocarcinomas. The mean follow-up was 25.9 months. The four recurrences (12.1%) occurred in: one tubulovillous adenoma, two in situ carcinomas, and one T2 lesion.

Conclusions

Transanal endoscopic microsurgery is appropriate for benign lesions such as carcinoid tumors and adenomas and can also be curative in carefully selected patients with early-stage invasive rectal cancer. In cases of invasive adenocarcinoma, it should be reserved for low-risk cancers in patients who accept the possible increased risk of recurrence.
Literature
2.
go back to reference Guillem J, Chessin D, Jeong S-Y, Kim W, Fogarty J-M (2005) Contemporary applications of transanal endoscopic microsurgery: technical innovations and limitations. Clinical colorectal cancer 5 (4):268–273PubMedCrossRef Guillem J, Chessin D, Jeong S-Y, Kim W, Fogarty J-M (2005) Contemporary applications of transanal endoscopic microsurgery: technical innovations and limitations. Clinical colorectal cancer 5 (4):268–273PubMedCrossRef
3.
go back to reference Blumberg D, Paty PB, Guillem JG, Picon AI, Minsky BD, Wong WD, Cohen AM (1999) All patients with small intramural rectal cancers are at risk for lymph node metastasis. Diseases of the Colon & Rectum 42 (7):881–885CrossRef Blumberg D, Paty PB, Guillem JG, Picon AI, Minsky BD, Wong WD, Cohen AM (1999) All patients with small intramural rectal cancers are at risk for lymph node metastasis. Diseases of the Colon & Rectum 42 (7):881–885CrossRef
4.
go back to reference Allaix M, Arezzo A, Caldart M, Festa F, Morino M (2009) Transanal endoscopic microsurgery for rectal neoplasms: experience of 300 consecutive cases. Diseases of the Colon & Rectum 52 (11):1831–1836CrossRef Allaix M, Arezzo A, Caldart M, Festa F, Morino M (2009) Transanal endoscopic microsurgery for rectal neoplasms: experience of 300 consecutive cases. Diseases of the Colon & Rectum 52 (11):1831–1836CrossRef
5.
go back to reference Tsai B, Finne C, Nordenstam J, Christoforidis D, Madoff R, Mellgren A (2010) Transanal endoscopic microsurgery resection of rectal tumors: outcomes and recommendations. Diseases of the Colon & Rectum 53 (1):16–23CrossRef Tsai B, Finne C, Nordenstam J, Christoforidis D, Madoff R, Mellgren A (2010) Transanal endoscopic microsurgery resection of rectal tumors: outcomes and recommendations. Diseases of the Colon & Rectum 53 (1):16–23CrossRef
6.
go back to reference de Graaf EJR, Doornebosch P, Tetteroo GWM, Geldof H, Hop WCJ (2009) Transanal endoscopic microsurgery is feasible for adenomas throughout the entire rectum: a prospective study. Diseases of the Colon & Rectum 52 (6):1107–1113CrossRef de Graaf EJR, Doornebosch P, Tetteroo GWM, Geldof H, Hop WCJ (2009) Transanal endoscopic microsurgery is feasible for adenomas throughout the entire rectum: a prospective study. Diseases of the Colon & Rectum 52 (6):1107–1113CrossRef
7.
go back to reference Christoforidis D, Cho H-M, Dixon M, Mellgren A, Madoff R, Finne C (2009) Transanal endoscopic microsurgery versus conventional transanal excision for patients with early rectal cancer. Annals of surgery 249 (5):776–782PubMedCrossRef Christoforidis D, Cho H-M, Dixon M, Mellgren A, Madoff R, Finne C (2009) Transanal endoscopic microsurgery versus conventional transanal excision for patients with early rectal cancer. Annals of surgery 249 (5):776–782PubMedCrossRef
8.
go back to reference Bach SP, Hill J, Monson JR, Simson JN, Lane L, Merrie A, Warren B, Mortensen NJ (2009) A predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer. Br J Surg 96 (3):280–290. doi:10.1002/bjs.6456 PubMedCrossRef Bach SP, Hill J, Monson JR, Simson JN, Lane L, Merrie A, Warren B, Mortensen NJ (2009) A predictive model for local recurrence after transanal endoscopic microsurgery for rectal cancer. Br J Surg 96 (3):280–290. doi:10.​1002/​bjs.​6456 PubMedCrossRef
9.
go back to reference Moore J, Cataldo P, Osler T, Hyman N (2008) Transanal endoscopic microsurgery is more effective than traditional transanal excision for resection of rectal masses. Diseases of the Colon & Rectum 51 (7):1026–1030CrossRef Moore J, Cataldo P, Osler T, Hyman N (2008) Transanal endoscopic microsurgery is more effective than traditional transanal excision for resection of rectal masses. Diseases of the Colon & Rectum 51 (7):1026–1030CrossRef
10.
go back to reference Langer C, Liersch T, Sss M, Siemer A, Markus P, Ghadimi BM, Fzesi L, Becker H (2003) Surgical cure for early rectal carcinoma and large adenoma: transanal endoscopic microsurgery (using ultrasound or electrosurgery) compared to conventional local and radical resection. International Journal of Colorectal Disease 18 (3):222–229PubMed Langer C, Liersch T, Sss M, Siemer A, Markus P, Ghadimi BM, Fzesi L, Becker H (2003) Surgical cure for early rectal carcinoma and large adenoma: transanal endoscopic microsurgery (using ultrasound or electrosurgery) compared to conventional local and radical resection. International Journal of Colorectal Disease 18 (3):222–229PubMed
12.
go back to reference Adam IJ, Mohamdee MO, Martin IG, Scott N, Finan PJ, Johnston D, Dixon MF, Quirke P (1994) Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 344 (8924):707–711PubMedCrossRef Adam IJ, Mohamdee MO, Martin IG, Scott N, Finan PJ, Johnston D, Dixon MF, Quirke P (1994) Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet 344 (8924):707–711PubMedCrossRef
13.
go back to reference Quirke P, Steele R, Monson J, Grieve R, Khanna S, Couture J, O’Callaghan C, Myint AS, Bessell E, Thompson LC, Parmar M, Stephens RJ, Sebag-Montefiore D (2009) Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet 373 (9666):821–828. doi:10.1016/S0140-6736(09)60485-2 PubMedCrossRef Quirke P, Steele R, Monson J, Grieve R, Khanna S, Couture J, O’Callaghan C, Myint AS, Bessell E, Thompson LC, Parmar M, Stephens RJ, Sebag-Montefiore D (2009) Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet 373 (9666):821–828. doi:10.​1016/​S0140-6736(09)60485-2 PubMedCrossRef
14.
go back to reference Brodsky JT, Richard GK, Cohen AM, Minsky BD (1992) Variables correlated with the risk of lymph node metastasis in early rectal cancer. Cancer 69 (2):322–326PubMedCrossRef Brodsky JT, Richard GK, Cohen AM, Minsky BD (1992) Variables correlated with the risk of lymph node metastasis in early rectal cancer. Cancer 69 (2):322–326PubMedCrossRef
15.
go back to reference Nascimbeni R, Burgart L, Nivatvongs S, Larson D (2002) Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Diseases of the Colon & Rectum 45 (2):200–206CrossRef Nascimbeni R, Burgart L, Nivatvongs S, Larson D (2002) Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Diseases of the Colon & Rectum 45 (2):200–206CrossRef
16.
go back to reference De Graaf EJR, Doornebosch PG, Tollenaar RAEM, Kranenbarg EM, de Boer AC, Bekkering FC, van de Velde CJH (2009) Transanal endoscopic microsurgery versus total mesorectal excision of T1 rectal adenocarcinomas with curative intention. European journal of surgical oncology 35 (12):1280–1285PubMedCrossRef De Graaf EJR, Doornebosch PG, Tollenaar RAEM, Kranenbarg EM, de Boer AC, Bekkering FC, van de Velde CJH (2009) Transanal endoscopic microsurgery versus total mesorectal excision of T1 rectal adenocarcinomas with curative intention. European journal of surgical oncology 35 (12):1280–1285PubMedCrossRef
17.
go back to reference Floyd N, Saclarides T (2006) Transanal endoscopic microsurgical resection of pT1 rectal tumors. Diseases of the Colon & Rectum 49 (2):164–168CrossRef Floyd N, Saclarides T (2006) Transanal endoscopic microsurgical resection of pT1 rectal tumors. Diseases of the Colon & Rectum 49 (2):164–168CrossRef
18.
go back to reference Landmann R, Wong WD, Hoepfl J, Shia J, Guillem J, Temple L, Paty P, Weiser M (2007) Limitations of early rectal cancer nodal staging may explain failure after local excision. Diseases of the Colon & Rectum 50 (10):1520–1525CrossRef Landmann R, Wong WD, Hoepfl J, Shia J, Guillem J, Temple L, Paty P, Weiser M (2007) Limitations of early rectal cancer nodal staging may explain failure after local excision. Diseases of the Colon & Rectum 50 (10):1520–1525CrossRef
20.
go back to reference Ganai S, Kanumuri P, Rao R, Alexander A (2006) Local recurrence after transanal endoscopic microsurgery for rectal polyps and early cancers. Annals of Surgical Oncology 13 (4):547–556PubMedCrossRef Ganai S, Kanumuri P, Rao R, Alexander A (2006) Local recurrence after transanal endoscopic microsurgery for rectal polyps and early cancers. Annals of Surgical Oncology 13 (4):547–556PubMedCrossRef
21.
go back to reference Friel CM, Cromwell JW, Marra C, Madoff RD, Rothenberger DA, Garcia-Aguilar J (2002) Salvage radical surgery after failed local excision for early rectal cancer. Dis Colon Rectum 45 (7):875–879PubMedCrossRef Friel CM, Cromwell JW, Marra C, Madoff RD, Rothenberger DA, Garcia-Aguilar J (2002) Salvage radical surgery after failed local excision for early rectal cancer. Dis Colon Rectum 45 (7):875–879PubMedCrossRef
22.
go back to reference Weiser M, Landmann R, Wong WD, Shia J, Guillem J, Temple L, Minsky B, Cohen A, Paty P (2005) Surgical salvage of recurrent rectal cancer after transanal excision. Diseases of the Colon & Rectum 48 (6):1169–1175CrossRef Weiser M, Landmann R, Wong WD, Shia J, Guillem J, Temple L, Minsky B, Cohen A, Paty P (2005) Surgical salvage of recurrent rectal cancer after transanal excision. Diseases of the Colon & Rectum 48 (6):1169–1175CrossRef
23.
go back to reference Kjeldsen BJ, Kronborg O, Fenger C, Jrgensen OD (1997) A prospective randomized study of follow-up after radical surgery for colorectal cancer. British journal of surgery 84 (5):666–669PubMedCrossRef Kjeldsen BJ, Kronborg O, Fenger C, Jrgensen OD (1997) A prospective randomized study of follow-up after radical surgery for colorectal cancer. British journal of surgery 84 (5):666–669PubMedCrossRef
24.
go back to reference Makela JT, Laitinen SO, Kairaluoma MI (1995) Five-year follow-up after radical surgery for colorectal cancer. Results of a prospective randomized trial. Arch Surg 130 (10):1062–1067PubMed Makela JT, Laitinen SO, Kairaluoma MI (1995) Five-year follow-up after radical surgery for colorectal cancer. Results of a prospective randomized trial. Arch Surg 130 (10):1062–1067PubMed
25.
go back to reference Pietra N, Sarli L, Costi R, Ouchemi C, Grattarola M, Peracchia A (1998) Role of follow-up in management of local recurrences of colorectal cancer: a prospective, randomized study. Diseases of the Colon & Rectum 41 (9):1127–1133CrossRef Pietra N, Sarli L, Costi R, Ouchemi C, Grattarola M, Peracchia A (1998) Role of follow-up in management of local recurrences of colorectal cancer: a prospective, randomized study. Diseases of the Colon & Rectum 41 (9):1127–1133CrossRef
26.
go back to reference Secco G, Fardelli R, Gianquinto D, Bonfante P, Baldi E, Ravera G, Derchi L, Ferraris R (2002) Efficacy and cost of risk-adapted follow-up in patients after colorectal cancer surgery: a prospective, randomized and controlled trial. European journal of surgical oncology 28 (4):418–423PubMedCrossRef Secco G, Fardelli R, Gianquinto D, Bonfante P, Baldi E, Ravera G, Derchi L, Ferraris R (2002) Efficacy and cost of risk-adapted follow-up in patients after colorectal cancer surgery: a prospective, randomized and controlled trial. European journal of surgical oncology 28 (4):418–423PubMedCrossRef
27.
go back to reference Rodriguez-Moranta F, Salo J, Arcusa A, Boadas J, Pinol V, Bessa X, Batiste-Alentorn E, Lacy AM, Delgado S, Maurel J, Pique JM, Castells A (2006) Postoperative surveillance in patients with colorectal cancer who have undergone curative resection: a prospective, multicenter, randomized, controlled trial. J Clin Oncol 24 (3):386–393. doi:10.1200/JCO.2005.02.0826 PubMedCrossRef Rodriguez-Moranta F, Salo J, Arcusa A, Boadas J, Pinol V, Bessa X, Batiste-Alentorn E, Lacy AM, Delgado S, Maurel J, Pique JM, Castells A (2006) Postoperative surveillance in patients with colorectal cancer who have undergone curative resection: a prospective, multicenter, randomized, controlled trial. J Clin Oncol 24 (3):386–393. doi:10.​1200/​JCO.​2005.​02.​0826 PubMedCrossRef
Metadata
Title
Initial Experience with Transanal Endoscopic Microsurgery: the Need for Understanding the Limitations
Authors
Emily Steinhagen
Gerard Chang
José G. Guillem
Publication date
01-06-2011
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 6/2011
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-011-1496-8

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