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01-10-2009 | Original Article

Perioperative Selective Decontamination of the Digestive Tract (SDD) in Elective Colorectal Surgery

Authors: Daphne Roos, Lea M. Dijksman, Brigitte M. Sondermeijer, Heleen M. Oudemans-van Straaten, Laurens T. de Wit, Michael F. Gerhards

Published in: Journal of Gastrointestinal Surgery | Issue 10/2009

Abstract

Background

Selective decontamination of the digestive tract (SDD) decreases morbidity and mortality in critically ill patients and morbidity in patients undergoing esophageal resection. This study analyzes the effect of perioperative SDD in patients undergoing elective colorectal surgery on postoperative infections and anastomotic leakage.

Methods

This is a retrospective analysis of prospectively collected data in a 3-year cohort of 162 patients undergoing elective resection of colon and or rectum. Of these patients, 76 (47%) received SDD (polymyxine B sulfate, tobramycin, and amphotericin) perioperatively. The control group consisted of 86 patients who were not treated with SDD. Postoperative complications, hospital stay, and mortality were analyzed.

Results

In the SDD group, there were six patients (7.9%) with infectious complications compared with 17 patients (19.8%) in the control group (p = 0.031). The incidence of the combined endpoint infectious complications and anastomotic leakage was 8 (11%) in the SDD group vs. 22 (26%) in the control group (p = 0.014). Multivariate analysis showed that no-SDD, aged above 60 years and diabetes were independent predictors of postoperative complications.

Conclusion

Perioperative SDD in elective colorectal surgery seems to reduce postoperative surgical complications including infectious complications and anastomotic leakage. Prospective, randomized, placebo-controlled studies are needed to confirm this conclusion.

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Title: Perioperative Selective Decontamination of the Digestive Tract (SDD) in Elective Colorectal Surgery
Authors: Daphne Roos
Lea M. Dijksman
Brigitte M. Sondermeijer
Heleen M. Oudemans-van Straaten
Laurens T. de Wit
Michael F. Gerhards
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: Journal of Gastrointestinal Surgery / Issue 10/2009
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI: https://doi.org/10.1007/s11605-009-0970-z

2024 ASCO Annual Meeting

Springer Medicine

Perioperative Selective Decontamination of the Digestive Tract (SDD) in Elective Colorectal Surgery

Abstract

Background

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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