Skip to main content
Top
Published in: Journal of Gastrointestinal Surgery 9/2009

01-09-2009 | Original Article

A Reduction in Delayed Gastric Emptying by Classic Pancreaticoduodenectomy with an Antecolic Gastrojejunal Anastomosis and a Retrogastric Omental Patch

Authors: Mehrdad Nikfarjam, Eric T. Kimchi, Niraj J. Gusani, Syed M. Shah, Mandeep Sehmbey, Serene Shereef, Kevin F. Staveley-O’Carroll

Published in: Journal of Gastrointestinal Surgery | Issue 9/2009

Login to get access

Abstract

Background

Delayed gastric emptying (DGE) continues to be a major cause of morbidity following pancreaticoduodenectomy (PD). A change in the method of reconstruction following PD was instituted in an attempt to reduce the incidence DGE.

Methods

Patients undergoing PD from January 2002 to December 2008 were reviewed and outcomes determined. Pylorus-preserving pancreaticoduodenectomy (PPPD) with a retrocolic duodenojejunal anastomosis (n = 79) or a classic PD with a retrocolic gastrojejunostomy (n = 36) was performed prior to January 2008. Thereafter, a classic PD with an antecolic gastrojejunal anastomosis and placement of a retrogastric vascular omental patch was undertaken (n = 36).

Results

A statistically significant decrease in DGE was noted in the antecolic group compared to the entire retrocolic group (14% vs 40%; p = 0.004) and compared to patients treated by classic PD with a retrocolic anastomosis alone (14% vs 39%; p = 0.016). On multivariate analysis, the only modifiable factor associated with reduced DGE was the antecolic technique with an omental patch, odds ratio (OR) 0.3 (confidence interval (CI) 0.1–0.8) p = 0.022. Male gender was associated with an increased risk of DGE with OR 2.3 (CI 1.1–4.8) p = 0.026.

Conclusion

A classic PD combined with an antecolic anastomosis and retrogastric vascular omental patch results in a significant reduction in DGE.
Literature
1.
go back to reference Trede M, Saeger HD, Schwall G, et al. Resection of pancreatic cancer—surgical achievements. Langenbecks Arch Surg. 1998;383:121–128.PubMed Trede M, Saeger HD, Schwall G, et al. Resection of pancreatic cancer—surgical achievements. Langenbecks Arch Surg. 1998;383:121–128.PubMed
9.
go back to reference Miedema BW, Sarr MG, van Heerden JA, et al. Complications following pancreaticoduodenectomy. Current management. Arch Surg. 1992;127:945–949. discussion 949–950.PubMed Miedema BW, Sarr MG, van Heerden JA, et al. Complications following pancreaticoduodenectomy. Current management. Arch Surg. 1992;127:945–949. discussion 949–950.PubMed
11.
go back to reference Izbicki JR, Bloechle C, Broering DC, et al. Extended drainage versus resection in surgery for chronic pancreatitis: a prospective randomized trial comparing the longitudinal pancreaticojejunostomy combined with local pancreatic head excision with the pylorus-preserving pancreatoduodenectomy. Ann Surg. 1998;228:771–779. doi:10.1097/00000658-199812000-00008.PubMedCrossRef Izbicki JR, Bloechle C, Broering DC, et al. Extended drainage versus resection in surgery for chronic pancreatitis: a prospective randomized trial comparing the longitudinal pancreaticojejunostomy combined with local pancreatic head excision with the pylorus-preserving pancreatoduodenectomy. Ann Surg. 1998;228:771–779. doi:10.​1097/​00000658-199812000-00008.PubMedCrossRef
12.
15.
16.
go back to reference Hocking MP, Harrison WD, Sninsky CA. Gastric dysrhythmias following pylorus-preserving pancreaticoduodenectomy. Possible mechanism for early delayed gastric emptying. Dig Dis Sci. 1990;35:1226–1230. doi:10.1007/BF01536411.PubMedCrossRef Hocking MP, Harrison WD, Sninsky CA. Gastric dysrhythmias following pylorus-preserving pancreaticoduodenectomy. Possible mechanism for early delayed gastric emptying. Dig Dis Sci. 1990;35:1226–1230. doi:10.​1007/​BF01536411.PubMedCrossRef
18.
go back to reference Liberski SM, Koch KL, Atnip RG, et al. Ischemic gastroparesis: resolution after revascularization. Gastroenterology 1990;99:252–257.PubMed Liberski SM, Koch KL, Atnip RG, et al. Ischemic gastroparesis: resolution after revascularization. Gastroenterology 1990;99:252–257.PubMed
19.
go back to reference Tanaka M, Sarr MG. Role of the duodenum in the control of canine gastrointestinal motility. Gastroenterology 1988;94:622–629.PubMed Tanaka M, Sarr MG. Role of the duodenum in the control of canine gastrointestinal motility. Gastroenterology 1988;94:622–629.PubMed
27.
go back to reference Tait IS. Whipple's resection—proximal pancreaticoduodenectomy (PD). J R Coll Surg Edinb. 2002;47:528–540.PubMed Tait IS. Whipple's resection—proximal pancreaticoduodenectomy (PD). J R Coll Surg Edinb. 2002;47:528–540.PubMed
33.
38.
go back to reference Tanaka A, Ueno T, Oka M, et al. Effect of denervation of the pylorus and transection of the duodenum on acetaminophen absorption in rats; possible mechanism for early delayed gastric emptying after pylorus preserving pancreatoduodenectomy. Tohoku J Exp Med. 2000;192:239–247. doi:10.1620/tjem.192.239.PubMedCrossRef Tanaka A, Ueno T, Oka M, et al. Effect of denervation of the pylorus and transection of the duodenum on acetaminophen absorption in rats; possible mechanism for early delayed gastric emptying after pylorus preserving pancreatoduodenectomy. Tohoku J Exp Med. 2000;192:239–247. doi:10.​1620/​tjem.​192.​239.PubMedCrossRef
40.
go back to reference Ueno T, Tanaka A, Hamanaka Y, et al. A proposal mechanism of early delayed gastric emptying after pylorus preserving pancreatoduodenectomy. Hepatogastroenterology 1995;42:269–274.PubMed Ueno T, Tanaka A, Hamanaka Y, et al. A proposal mechanism of early delayed gastric emptying after pylorus preserving pancreatoduodenectomy. Hepatogastroenterology 1995;42:269–274.PubMed
41.
go back to reference Lin PW, Shan YS, Lin YJ, et al. Pancreaticoduodenectomy for pancreatic head cancer: PPPD versus Whipple procedure. Hepatogastroenterology 2005;52:1601–1604.PubMed Lin PW, Shan YS, Lin YJ, et al. Pancreaticoduodenectomy for pancreatic head cancer: PPPD versus Whipple procedure. Hepatogastroenterology 2005;52:1601–1604.PubMed
46.
go back to reference Han SS, Kim SW, Jang JY, et al. A comparison of the long-term functional outcomes of standard pancreatoduodenectomy and pylorus-preserving pancreatoduodenectomy. Hepatogastroenterology 2007;54:1831–1835.PubMed Han SS, Kim SW, Jang JY, et al. A comparison of the long-term functional outcomes of standard pancreatoduodenectomy and pylorus-preserving pancreatoduodenectomy. Hepatogastroenterology 2007;54:1831–1835.PubMed
47.
go back to reference Warshaw AL, Torchiana DL. Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy. Surg Gynecol Obstet. 1985;160:1–4.PubMed Warshaw AL, Torchiana DL. Delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy. Surg Gynecol Obstet. 1985;160:1–4.PubMed
48.
go back to reference van Berge Henegouwen MI, van Gulik TM, DeWit LT, et al. Delayed gastric emptying after standard pancreaticoduodenectomy versus pylorus-preserving pancreaticoduodenectomy: an analysis of 200 consecutive patients. J Am Coll Surg. 1997;185:373–379. doi:10.1016/S1072-7515(97)00078-1.PubMed van Berge Henegouwen MI, van Gulik TM, DeWit LT, et al. Delayed gastric emptying after standard pancreaticoduodenectomy versus pylorus-preserving pancreaticoduodenectomy: an analysis of 200 consecutive patients. J Am Coll Surg. 1997;185:373–379. doi:10.​1016/​S1072-7515(97)00078-1.PubMed
49.
go back to reference Patel AG, Toyama MT, Kusske AM, et al. Pylorus-preserving Whipple resection for pancreatic cancer. Is it any better? Arch Surg 1995;130:838–842. discussion 842–833.PubMed Patel AG, Toyama MT, Kusske AM, et al. Pylorus-preserving Whipple resection for pancreatic cancer. Is it any better? Arch Surg 1995;130:838–842. discussion 842–833.PubMed
50.
go back to reference Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg. 2002;236:355–366. doi:10.1097/00000658-200209000-00012 discussion 366–358.PubMedCrossRef Yeo CJ, Cameron JL, Lillemoe KD, et al. Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg. 2002;236:355–366. doi:10.​1097/​00000658-200209000-00012 discussion 366–358.PubMedCrossRef
51.
go back to reference Paraskevas KI, Avgerinos C, Manes C, et al. Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy: a review of the literature and critical reappraisal of the implicated pathomechanism. World J Gastroenterol. 2006;12:5951–5958.PubMed Paraskevas KI, Avgerinos C, Manes C, et al. Delayed gastric emptying is associated with pylorus-preserving but not classical Whipple pancreaticoduodenectomy: a review of the literature and critical reappraisal of the implicated pathomechanism. World J Gastroenterol. 2006;12:5951–5958.PubMed
56.
go back to reference Kingsnorth AN, Berg JD, Gray MR. A novel reconstructive technique for pylorus-preserving pancreaticoduodenectomy: avoidance of early postoperative gastric stasis. Ann R Coll Surg Engl. 1993;75:38–42.PubMed Kingsnorth AN, Berg JD, Gray MR. A novel reconstructive technique for pylorus-preserving pancreaticoduodenectomy: avoidance of early postoperative gastric stasis. Ann R Coll Surg Engl. 1993;75:38–42.PubMed
61.
go back to reference Yeo CJ, Cameron JL, Sohn TA, et al. Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short-term outcome. Ann Surg. 1999;229:613–622. doi:10.1097/00000658-199905000-00003 discussion 622–614.PubMedCrossRef Yeo CJ, Cameron JL, Sohn TA, et al. Pancreaticoduodenectomy with or without extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma: comparison of morbidity and mortality and short-term outcome. Ann Surg. 1999;229:613–622. doi:10.​1097/​00000658-199905000-00003 discussion 622–614.PubMedCrossRef
62.
go back to reference Howard JM. Pancreatojejunostomy: leakage is a preventable complication of the Whipple resection. J Am Coll Surg. 1997;184:454–457.PubMed Howard JM. Pancreatojejunostomy: leakage is a preventable complication of the Whipple resection. J Am Coll Surg. 1997;184:454–457.PubMed
Metadata
Title
A Reduction in Delayed Gastric Emptying by Classic Pancreaticoduodenectomy with an Antecolic Gastrojejunal Anastomosis and a Retrogastric Omental Patch
Authors
Mehrdad Nikfarjam
Eric T. Kimchi
Niraj J. Gusani
Syed M. Shah
Mandeep Sehmbey
Serene Shereef
Kevin F. Staveley-O’Carroll
Publication date
01-09-2009
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 9/2009
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-009-0944-1

Other articles of this Issue 9/2009

Journal of Gastrointestinal Surgery 9/2009 Go to the issue