Skip to main content
Top
Published in: Journal of Gastrointestinal Surgery 8/2008

01-08-2008 | SSAT Poster Presentation

Evaluation of Surgical Outcomes and Gallbladder Characteristics in Patients with Biliary Dyskinesia

Authors: M. Shirin Sabbaghian, Barrie S. Rich, Gary D. Rothberger, Jonathan Cohen, Steven Batash, Elissa Kramer, H. Leon Pachter, Stuart G. Marcus, Peter Shamamian

Published in: Journal of Gastrointestinal Surgery | Issue 8/2008

Login to get access

Abstract

Introduction

This study was designed to compare symptomatic outcomes following cholecystectomy in patients with biliary dyskinesia.

Materials and Methods

From 1999 to 2006 at New York University Medical Center, 197 adults underwent hepatobiliary scintigraphy with cholecystokinin administration to evaluate gallbladder ejection fraction (GBEF). Biliary dyskinesia was demonstrated in 120 patients based on decreased GBEF of ≤35%. Forty-four patients underwent cholecystectomy, and data from chart review and telephone questionnaires were available for 42 patients. Patients reported symptomatic improvement whether gallstones were present (25/27, 92.6%) or absent (13/15, 86.7%) prior to cholecystectomy (p = 0.90). The most common pathologic findings were chronic cholecystitis and cholesterolosis, regardless of the presence of gallstones. Additional data from 101 of the 120 patients with decreased GBEF demonstrated 74/101 (73.2%) patients were diagnosed with gastroesophageal reflux disease (GERD), and 59/101 (58.4%) patients were diagnosed with gastritis.

Results

The results of this study suggest that biliary dyskinesia should be considered as part of the spectrum of symptomatic gallbladder disease that can be successfully treated with cholecystectomy and that biliary dyskinesia is associated with GERD and gastritis.
Literature
2.
go back to reference Barron LG, Rubio PA. Importance of accurate preoperative diagnosis and role of advanced laparoscopic cholecystectomy in relieving chronic acalculous cholecystitis. J Laparoendosc Surg 1995;5:357–361. Medline.PubMed Barron LG, Rubio PA. Importance of accurate preoperative diagnosis and role of advanced laparoscopic cholecystectomy in relieving chronic acalculous cholecystitis. J Laparoendosc Surg 1995;5:357–361. Medline.PubMed
3.
go back to reference Krishnamurthy GT, Bobba VR, Kingston E. Radionuclide ejection fraction: a technique for quantitative analysis of motor function of the human gallbladder. Gastroenterology 1981;80:482–490. Medline.PubMed Krishnamurthy GT, Bobba VR, Kingston E. Radionuclide ejection fraction: a technique for quantitative analysis of motor function of the human gallbladder. Gastroenterology 1981;80:482–490. Medline.PubMed
4.
go back to reference Majeski J. Gallbladder ejection fraction: an accurate evaluation of symptomatic acalculous gallbladder disease. Int Surg 2003;88:95–99. Medline.PubMed Majeski J. Gallbladder ejection fraction: an accurate evaluation of symptomatic acalculous gallbladder disease. Int Surg 2003;88:95–99. Medline.PubMed
5.
go back to reference Misra DC Jr, Blossom GB, Fink-Bennett D, Glover JL. Results of surgical therapy for biliary dyskinesia. Arch Surg 1991;126:957–960. Medline.PubMed Misra DC Jr, Blossom GB, Fink-Bennett D, Glover JL. Results of surgical therapy for biliary dyskinesia. Arch Surg 1991;126:957–960. Medline.PubMed
12.
go back to reference Yap L, Wycherley AG, Morphett AD, Toouli J. Acalculous biliary pain: cholecystectomy alleviates symptoms in patients with abnormal cholescintigraphy. Gastroenterology 1991;101:786–793. Medline.PubMed Yap L, Wycherley AG, Morphett AD, Toouli J. Acalculous biliary pain: cholecystectomy alleviates symptoms in patients with abnormal cholescintigraphy. Gastroenterology 1991;101:786–793. Medline.PubMed
13.
go back to reference Cunningham CC, Sehon JK, Johnson LW, Zibari GB. Outcomes of surgical therapy for biliary dyskinesia. J La State Med Soc 2003;155:189–191. Medline.PubMed Cunningham CC, Sehon JK, Johnson LW, Zibari GB. Outcomes of surgical therapy for biliary dyskinesia. J La State Med Soc 2003;155:189–191. Medline.PubMed
15.
go back to reference Young SB, Arregui M, Singh K. HIDA scan ejection fraction does not predict sphincter of Oddi hypertension or clinical outcome in patients with suspected chronic acalculous cholecystitis. Surg Endosc 2006;20:1872–1878. Medline DOI 10.1007/s00464-005-0245-z.PubMedCrossRef Young SB, Arregui M, Singh K. HIDA scan ejection fraction does not predict sphincter of Oddi hypertension or clinical outcome in patients with suspected chronic acalculous cholecystitis. Surg Endosc 2006;20:1872–1878. Medline DOI 10.​1007/​s00464-005-0245-z.PubMedCrossRef
17.
go back to reference Messing B, Bories C, Kunstlinger F, Bernier JJ. Does total parenteral nutrition induce gallbladder sludge formation and lithiasis? Gastroenterology 1983;84:1012–1019. Medline.PubMed Messing B, Bories C, Kunstlinger F, Bernier JJ. Does total parenteral nutrition induce gallbladder sludge formation and lithiasis? Gastroenterology 1983;84:1012–1019. Medline.PubMed
19.
go back to reference Velanovich V. Biliary dyskinesia and biliary crystals: a prospective study. Am Surg 1997;63:69–74. Medline.PubMed Velanovich V. Biliary dyskinesia and biliary crystals: a prospective study. Am Surg 1997;63:69–74. Medline.PubMed
20.
go back to reference Krishnamurthy GT, Bobba VR, McConnell D, Turner F, Mesgarzadeh M, Kingston E. Quantitative biliary dynamics: introduction of a new noninvasive scintigraphic technique. J Nucl Med 1983;24:217–223. Medline.PubMed Krishnamurthy GT, Bobba VR, McConnell D, Turner F, Mesgarzadeh M, Kingston E. Quantitative biliary dynamics: introduction of a new noninvasive scintigraphic technique. J Nucl Med 1983;24:217–223. Medline.PubMed
22.
go back to reference Spechler SJ. Epidemiology and natural history of gastro-oesophageal reflux disease. Digestion 1992;51:24–29. Medline.PubMedCrossRef Spechler SJ. Epidemiology and natural history of gastro-oesophageal reflux disease. Digestion 1992;51:24–29. Medline.PubMedCrossRef
24.
go back to reference Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, Perez-Perez GI et al. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med 1989;321:1562–1566. Medline.PubMed Dooley CP, Cohen H, Fitzgibbons PL, Bauer M, Appleman MD, Perez-Perez GI et al. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med 1989;321:1562–1566. Medline.PubMed
28.
go back to reference Ledeboer M, Masclee AA, Batstra MR, Jansen JB, Lamers CB. Effect of cholecystokinin on lower oesophageal sphincter pressure and transient lower oesophageal sphincter relaxation in humans. Gut 1995;36:39–44. Medline DOI 10.1136/gut.36.1.39.PubMedCrossRef Ledeboer M, Masclee AA, Batstra MR, Jansen JB, Lamers CB. Effect of cholecystokinin on lower oesophageal sphincter pressure and transient lower oesophageal sphincter relaxation in humans. Gut 1995;36:39–44. Medline DOI 10.​1136/​gut.​36.​1.​39.PubMedCrossRef
29.
go back to reference Chowdhury JR, Berkowitz JM, Praissman M, Fara JW. Interaction between octapeptide-cholecystokinin, gastrin and secretin on cat gallbladder in vitro. Am J Physiol 1975;229:1311–1315. Medline.PubMed Chowdhury JR, Berkowitz JM, Praissman M, Fara JW. Interaction between octapeptide-cholecystokinin, gastrin and secretin on cat gallbladder in vitro. Am J Physiol 1975;229:1311–1315. Medline.PubMed
30.
go back to reference Ryan J, Cohen S. Gallbladder pressure-volume response to gastrointestinal hormones. Am J Physiol 1976;230:1461–1465. Medline.PubMed Ryan J, Cohen S. Gallbladder pressure-volume response to gastrointestinal hormones. Am J Physiol 1976;230:1461–1465. Medline.PubMed
31.
go back to reference Stathopoulos P, Zundt B, Spelsberg FW, Kolligs L, Diebold J, Goke B et al. Relation of gallbladder function and Helicobacter pylori infection to gastric mucosa inflammation in patients with symptomatic cholecystolithiasis. Digestion 2006;73:69–74. Medline DOI 10.1159/000092746.PubMedCrossRef Stathopoulos P, Zundt B, Spelsberg FW, Kolligs L, Diebold J, Goke B et al. Relation of gallbladder function and Helicobacter pylori infection to gastric mucosa inflammation in patients with symptomatic cholecystolithiasis. Digestion 2006;73:69–74. Medline DOI 10.​1159/​000092746.PubMedCrossRef
32.
go back to reference Apostolov E, Al-Soud WA, Nilsson I, Kornilovska I, Usenko V, Lyzogubov V et al. Helicobacter pylori and other Helicobacter species in gallbladder and liver of patients with chronic cholecystitis detected by immunological and molecular methods. Scand J Gastroenterol 2005;40:96–102. Medline DOI 10.1080/00365520410009546.PubMedCrossRef Apostolov E, Al-Soud WA, Nilsson I, Kornilovska I, Usenko V, Lyzogubov V et al. Helicobacter pylori and other Helicobacter species in gallbladder and liver of patients with chronic cholecystitis detected by immunological and molecular methods. Scand J Gastroenterol 2005;40:96–102. Medline DOI 10.​1080/​0036552041000954​6.PubMedCrossRef
33.
go back to reference Chen DF, Hu L, Yi P, Liu WW, Fang DC, Cao H. H. pylori exists in the gallbladder mucosa of patients with chronic cholecystitis. World J Gastroenterol 2007;13:1608–1611. Medline.PubMed Chen DF, Hu L, Yi P, Liu WW, Fang DC, Cao H. H. pylori exists in the gallbladder mucosa of patients with chronic cholecystitis. World J Gastroenterol 2007;13:1608–1611. Medline.PubMed
Metadata
Title
Evaluation of Surgical Outcomes and Gallbladder Characteristics in Patients with Biliary Dyskinesia
Authors
M. Shirin Sabbaghian
Barrie S. Rich
Gary D. Rothberger
Jonathan Cohen
Steven Batash
Elissa Kramer
H. Leon Pachter
Stuart G. Marcus
Peter Shamamian
Publication date
01-08-2008
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 8/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-008-0546-3

Other articles of this Issue 8/2008

Journal of Gastrointestinal Surgery 8/2008 Go to the issue