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Journal of Gastrointestinal Surgery
Published in: Journal of Gastrointestinal Surgery 4/2008

01-04-2008 | original article

Defining the Role of Surgery for Primary Gastrointestinal Tract Melanoma

Authors: Michael C. Cheung, Eduardo A. Perez, Manuel A. Molina, Xiaoling Jin, Juan C. Gutierrez, Dido Franceschi, Alan S. Livingstone, Leonidas G. Koniaris

Published in: Journal of Gastrointestinal Surgery | Issue 4/2008

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Abstract

Objective

The objective of the study was to determine the outcomes for primary gastrointestinal melanomas (PGIM).

Material and methods

The Surveillance, Epidemiology, and End Results database (1973–2004) was queried.

Results

Overall, 659 cases of PGIM were identified. The annual incidence of PGIM was approximately 0.47 cases per million in 2000. Overall median survival time was 17 months. Tumors were identified in the oral–nasopharynx (32.8%), anal canal (31.4%), rectum (22.2%), esophagus (5.9%), stomach (2.7%), small bowel (2.3%), gallbladder (1.4%), and large bowel (0.9%). Univariate analysis demonstrated age, tumor location, stage, surgery, and lymph node status were significant predictors of improved survival. MST has not been reached for tumors located in the large bowel, while tumors located in the stomach demonstrated the shortest median survival (5 months). Improvement in MST was observed for those patients undergoing surgical resection. The presence of lymph node involvement conferred a poorer prognosis. Multivariate analysis of the cohort identified that location, advanced tumor stage, failure to undertake surgical resection, positive lymph node status, and age were all independent predictors of poorer outcome.

Conclusion

PGIM occurs most often in the oral–nasopharynx and anal canal. Surgical extirpation is the only identifiable treatment modality that significantly improves survival.
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Metadata
Title
Defining the Role of Surgery for Primary Gastrointestinal Tract Melanoma
Authors
Michael C. Cheung
Eduardo A. Perez
Manuel A. Molina
Xiaoling Jin
Juan C. Gutierrez
Dido Franceschi
Alan S. Livingstone
Leonidas G. Koniaris
Publication date
01-04-2008
Publisher
Springer-Verlag
Published in
Journal of Gastrointestinal Surgery / Issue 4/2008
Print ISSN: 1091-255X
Electronic ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-007-0417-3

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