Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 7/2018

01-07-2018 | Original Article

Magnetic resonance assessment of fetal lung maturity: comparison between signal intensity and volume measurement

Authors: Ryo Ogawa, Tomoyuki Kido, Masashi Nakamura, Teruhito Kido, Teruhito Mochizuki, Takashi Sugiyama

Published in: Japanese Journal of Radiology | Issue 7/2018

Login to get access

Abstract

Purpose

We evaluated the associations between gestational age (GA) and lung-to-liver signal intensity ratio (LLSIR) and fetal lung volume (FLV) using magnetic resonance imaging (MRI). Moreover, we evaluated the reproducibility of these measurements.

Materials and methods

LLSIR and FLV were measured using single-shot fast spin-echo MRI in 88 consecutive fetuses. The Spearman test was used to assess the relationships between (1) LLSIR and GA, and (2) FLV and GA in 81 fetuses without lung abnormalities. Intra- and inter-observer reliabilities were assessed using intra-class correlation coefficients (ICCs).

Results

Overall, GA and LLSIR were significantly correlated (r = 0.62, p < 0.001). However, GA and LLSIR were only significantly correlated during the third trimester (before third trimester: r = 0.39, p = 0.08; during third trimester: r = 0.46, p < 0.001). Overall, GA and FLV were significantly correlated (r = 0.72, p < 0.001). FLV was significantly correlated with GA before (r = 0.86, p < 0.001) and during the third trimester (r = 0.47, p < 0.001). All ICCs were above 0.90.

Conclusions

LLSIR and FLV are useful for the assessment of fetal lung maturity and are highly reproducible. Before the third trimester, FLV is more suitable than LLSIR for the evaluation of fetal lung maturity.
Literature
1.
Oka Y, Rahman M, Sasakura C, Waseda T, Watanabe Y, Fujii R, et al. Prenatal diagnosis of fetal respiratory function: evaluation of fetal lung maturity using lung-to-liver signal intensity ratio at magnetic resonance imaging. Prenat Diagn. 2014;34:1289–94.CrossRefPubMedPubMedCentral
2.
O’Brien WF, Cefalo RC. Clinical applicability of amniotic fluid tests for fetal pulmonic maturity. Am J Obstet Gynecol. 1980;136:135–44.CrossRefPubMed
3.
Rubesova E. Why do we need more data on MR volumetric measurements of the fetal lung? Pediatr Radiol. 2016;46:167–71.CrossRefPubMed
4.
Jaffe TA, Miller CM, Merkle EM. Practice patterns in imaging of the pregnant patient with abdominal pain: a survey of academic centers. AJR Am J Roentgenol. 2007;189:1128–34.CrossRefPubMed
5.
Ray JG, Vermeulen MJ, Bharatha A, Montanera WJ, Park AL. Association between MRI exposure during pregnancy and fetal and childhood outcomes. JAMA. 2016;316:952–61.CrossRefPubMed
6.
Moshiri M, Mannelli L, Richardson ML, Bhargava P, Dubinsky TJ. Fetal lung maturity assessment with MRI fetal lung-to-liver signal-intensity ratio. AJR Am J Roentgenol. 2013;201:1386–90.CrossRefPubMed
7.
Kasprian G, Balassy C, Brugger PC, Prayer D. MRI of normal and pathological fetal lung development. Eur J Radiol. 2006;57:261–70.CrossRefPubMed
8.
Kuwashima S, Nishimura G, Iimura F, Kohno T, Watanabe H, Kohno A, et al. Low-intensity fetal lungs on MRI may suggest the diagnosis of pulmonary hypoplasia. Pediatr Radiol. 2001;31:669–72.CrossRefPubMed
9.
Paek BW, Coakley FV, Lu Y, Filly RA, Lopoo JB, Qayyum A. Congenital diaphragmatic hernia: prenatal evaluation with MR lung volumetry—preliminary experience. Radiology. 2001;220:63–7.CrossRefPubMed
10.
Brewerton LJ, Chari RS, Liang Y, Bhargava R. Fetal lung-to-liver signal intensity ratio at MR imaging: development of a normal scale and possible role in predicting pulmonary hypoplasia in utero. Radiology. 2005;235:1005–10.CrossRefPubMed
11.
van der Vorst JR, van Dam RM, van Stiphout RS, van den Broek MA, Hollander IH, Kessels AG, et al. Virtual liver resection and volumetric analysis of the future liver remnant using open source image processing software. World J Surg. 2010;34:2426–33.CrossRefPubMedPubMedCentral
12.
Ward VL, Nishino M, Hatabu H, Estroff JA, Barnewolt CE, Feldman HA, et al. Fetal lung volume measurements: determination with MR imaging—effect of various factors. Radiology. 2006;240:187–93.CrossRefPubMed
13.
Keller TM, Rake A, Michel SC, Seifert B, Wisser J, Marincek B, et al. MR assessment of fetal lung development using lung volumes and signal intensities. Eur Radiol. 2004;14:984–9.CrossRefPubMed
14.
Osada H, Kaku K, Masuda K, Iitsuka Y, Seki K, Sekiya S. Quantitative and qualitative evaluations of fetal lung with MR imaging. Radiology. 2004;231:887–92.CrossRefPubMed
15.
Mills M, Winter TC, Kennedy AM, Woodward PJ. Determination of fetal lung maturity using magnetic resonance imaging signal intensity measurements. Ultrasound Q. 2014;30:61–7.CrossRefPubMed
16.
Laudy JA, Wladimiroff JW. The fetal lung. 1: developmental aspects. Ultrasound Obstet Gynecol. 2000;16:284–90.CrossRefPubMed
17.
Dubinsky TJ, Moshiri M, Adams Waldorf K, Wilson G, Maki JH, Hippe DS. Increased fetal lung T2 signal is not due to increasing surfactant concentration: an in vitro T2 mapping analysis. Prenat Diagn. 2017;37:211–4.CrossRefPubMedPubMedCentral
18.
Duncan KR, Gowland PA, Moore RJ, Baker PN, Johnson IR. Assessment of fetal lung growth in utero with echo-planar MR imaging. Radiology. 1999;210:197–200.CrossRefPubMed
19.
Deshmukh S, Rubesova E, Barth R. MR assessment of normal fetal lung volumes: a literature review. AJR Am J Roentgenol. 2010;194:W212–7.CrossRefPubMed
20.
Rypens F, Metens T, Rocourt N, Sonigo P, Brunelle F, Quere MP. Fetal lung volume: estimation at MR imaging-initial results. Radiology. 2001;219:236–41.CrossRefPubMed
Metadata
Title
Magnetic resonance assessment of fetal lung maturity: comparison between signal intensity and volume measurement
Authors
Ryo Ogawa
Tomoyuki Kido
Masashi Nakamura
Teruhito Kido
Teruhito Mochizuki
Takashi Sugiyama
Publication date
01-07-2018
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 7/2018
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-018-0745-0

Other articles of this Issue 7/2018

Japanese Journal of Radiology 7/2018 Go to the issue

Original Article

Changes in the ADC of diffusion-weighted MRI with the oscillating gradient spin-echo (OGSE) sequence due to differences in substrate viscosities

Original Article

Simulation study of dosimetric effect in proton beam therapy using concomitant boost technique for unresectable pancreatic cancers

Original Article

Uterine endometrial carcinoma with DNA mismatch repair deficiency: magnetic resonance imaging findings and clinical features

Original Article

Cardiac computed tomography as a viable alternative to echocardiography to detect vegetations and perivalvular complications in patients with infective endocarditis

Original Article

The feasibility of high-pitch acquisition protocol for imaging of the pediatric abdomen by dual-source CT

Original Article

Central venous access port placement by translumbar approach using angio-CT unit in patients with superior vena cava syndrome