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01-06-2013 | Original Article

Effect of lapatinib on hepatic parenchymal enhancement on gadoxetate disodium (EOB)-enhanced MRI scans of the rat liver

Authors: Yuko Nakamura, Yutaka Hirokawa, Shigemi Kitamura, Wataru Yamasaki, Koji Arihiro, Fuminari Tatsugami, Makoto Iida, Hideaki Kakizawa, Shuji Date, Kazuo Awai

Published in: Japanese Journal of Radiology | Issue 6/2013

Abstract

Purpose

The purpose of this study was to investigate the effect of lapatinib treatment on hepatic parenchymal enhancement on Gd-EOB-MRI scans in rat.

Materials and methods

Institutional animal review board approval was received prior to the commencement of all studies. Five rats received a single oral dose of 100 mg/kg/day lapatinib for 7 consecutive days. The controls (n = 5) were given 0.5 % (w/v) aqueous hydroxypropyl methyl cellulose containing 0.1 % (v/v) Tween 80 for 7 days. After the acquisition of gadoxetate disodium-enhanced MR images using 0.025 mmol gadolinium/kg, their livers were subjected to pathologic study to determine the expression level of organic anion-transporting polypeptide 1 (oatp1) and multi-drug resistance-associated protein 2 (mrp2).

Results

Relative enhancement of the liver was similar in both groups. At the hepatobiliary phase, which in rats occurs 3 min after the injection of Gd-EOB, it was 0.90 ± 0.06 in lapatinib-treated rats and 0.84 ± 0.08 in the controls (p = 0.30). There was also no difference in the expression level of oatp1 and mrp2.

Conclusion

In rats, the administration of lapatinib for 7 days had no effect on hepatic parenchymal enhancement on Gd-EOB-MRI scans.

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Title: Effect of lapatinib on hepatic parenchymal enhancement on gadoxetate disodium (EOB)-enhanced MRI scans of the rat liver
Authors: Yuko Nakamura
Yutaka Hirokawa
Shigemi Kitamura
Wataru Yamasaki
Koji Arihiro
Fuminari Tatsugami
Makoto Iida
Hideaki Kakizawa
Shuji Date
Kazuo Awai
Publication date: 01-06-2013
Publisher: Springer Japan
Published in: Japanese Journal of Radiology / Issue 6/2013
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-013-0208-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of lapatinib on hepatic parenchymal enhancement on gadoxetate disodium (EOB)-enhanced MRI scans of the rat liver

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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