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Japanese Journal of Radiology

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01-04-2013 | Original Article

Outcomes of patients with stage IVA esophageal cancer (Japanese classification) treated with definitive chemoradiotherapy

Authors: Akira Anbai, Makoto Koga, Satoru Motoyama, Mario Jin, Hiroyuki Shibata, Manabu Hashimoto

Published in: Japanese Journal of Radiology | Issue 4/2013

Abstract

Purpose

To evaluate treatment outcomes of chemoradiotherapy for patients with stage IVA esophageal cancer and to estimate prognostic factors.

Materials and methods

Patients with stage IVA esophageal cancer treated with chemoradiotherapy between April 2003 and March 2009 were evaluated. Patients received concurrent chemoradiotherapy comprising cisplatin plus 5-fluorouracil and 61.2 Gy of radiotherapy. Therapeutic response, overall survival time, and toxicity were examined and statistical evaluation was performed.

Results

Ninety patients were treated using chemoradiotherapy. Among these, 71 patients (78.9 %) received the complete course of chemoradiotherapy. Seventeen patients (18.9 %) showed complete response, 64 patients (71.1 %) had partial response, 7 patients (7.8 %) experienced no change, and 2 patients (2.2 %) exhibited progressive disease. Mean duration of follow-up was 16.1 months (range 2–88 months). Median overall survival was 12.8 months. Two- and 3-year overall survival rates were 35.1 and 18.6 %, respectively. Severe hematological toxicities included Grade 3 leukopenia in 33 patients (36.7 %). Treatment-related death was estimated to have occurred in 7 patients. Performance status and body weight loss were identified as significant prognostic factors.

Conclusion

Our treatment outcomes appeared similar to those of previous studies that used chemoradiotherapy for advanced esophageal cancer. This treatment is useful for stage IVA esophageal cancer.

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Title: Outcomes of patients with stage IVA esophageal cancer (Japanese classification) treated with definitive chemoradiotherapy
Authors: Akira Anbai
Makoto Koga
Satoru Motoyama
Mario Jin
Hiroyuki Shibata
Manabu Hashimoto
Publication date: 01-04-2013
Publisher: Springer Japan
Published in: Japanese Journal of Radiology / Issue 4/2013
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI: https://doi.org/10.1007/s11604-013-0180-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Outcomes of patients with stage IVA esophageal cancer (Japanese classification) treated with definitive chemoradiotherapy

Abstract

Purpose

Materials and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Materials and methods

Results

Conclusion

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