Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 2/2012

01-02-2012 | Original article

Diffusion-weighted imaging findings of mucinous carcinoma arising in the ano-rectal region: comparison of apparent diffusion coefficient with that of tubular adenocarcinoma

Authors: Katsuhiro Nasu, Yoshifumi Kuroki, Manabu Minami

Published in: Japanese Journal of Radiology | Issue 2/2012

Login to get access

Abstract

Purpose

To determine the diffusion-weighted imaging (DWI) characteristics of ano-rectal mucinous carcinoma. Apparent diffusion coefficient (ADC) and DWI findings for mucinous and tubular adenocarcinomas were retrospectively compared.

Materials and methods

Eight-one consecutive surgically resected ano-rectal adenocarcinomas were evaluated. The patient group consisted of 15 mucinous and 66 tubular adenocarcinomas. The DWI signal intensity (SI) pattern of each tumor was visually classified into one of three groups. Differences in the proportions in each group were statistically compared for the two types of tumor. The ADCs of each tumor, calculated from two different b-factors (0 and 1500 s/mm2) were compared statistically.

Results

Visual evaluation revealed ten mucinous carcinomas as predominantly hypointense lesions, and the remaining five as mixed SI lesions. Sixty-one of 66 tubular adenocarcinomas had hyperintensities; the remaining five had mixed SI. The different proportions in each group were statistically significant. The mean ADC for mucinous carcinomas was 1.49 ± 0.34 × 10−3 mm2/s whereas that for tubular adenocarcinomas was 0.80 ± 0.15 × 10−3 mm2/s. The difference between those figures was statistically significant.

Conclusion

In DWI, mucinous carcinomas had higher ADCs and lower SI than tubular adenocarcinomas. DWI and ADC measurements were useful for differentiating these two tumors.
Literature
1.
Du W, Mah JT, Lee J, Sankila R, Sankaranarayanan R, Chia KS. Incidence and survival of mucinous adenocarcinoma of the colorectum: a population-based study from an Asian country. Dis Colon Rectum. 2004;47:78–85.PubMedCrossRef
2.
Consorti F, Lorenzotti A, Midiri G, Di Paola M. Prognostic significance of mucinous carcinoma of colon and rectum: a prospective case–control study. J Surg Oncol. 2000;73:70–4.PubMedCrossRef
3.
Yang BL, Shao WJ, Sun GD, Chen YQ, Huang JC. Perianal mucinous adenocarcinoma arising from chronic anorectal fistulae: a review from single institution. Int J Colorectal Dis. 2009;24:1001–6.PubMedCrossRef
4.
Green JB, Timmcke AE, Mitchell WT, Hicks TC, Gathright JB, Ray JE. Mucinous carcinoma—just another colon cancer? Dis Colon Rectum. 1993;36:49–54.PubMedCrossRef
5.
Yamamoto S, Mochizuki H, Yamamoto Y, Ohsuka Y, Yokoyama S, Ushitani Y, et al. Assessment of clinicopathologic features of colorectal mucinous adenocarcinoma. Am J Surg. 1993;166:257–61.PubMedCrossRef
6.
Teixeira CR, Tanaka S, Haruma K, Yoshihara M, Sumii K, Kajiyama G, et al. The clinical significance of the histologic subclassification of colorectal carcinoma. Oncology. 1993;50:495–9.PubMedCrossRef
7.
8.
Nasu K, Kuroki Y, Nawano S, Kuroki S, Tsukamoto T, Yamamoto S, et al. Hepatic metastases: diffusion-weighted sensitivity-encoding versus SPIO-enhanced MR imaging. Radiology. 2006;239:122–30.PubMedCrossRef
9.
Kuroki Y, Nasu K, Kuroki S, Murakami K, Hayashi T, Sekiguchi R. Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: analysis of the apparent diffusion coefficient value. Magn Reson Med Sci. 2004;3:79–85.PubMedCrossRef
10.
Shimofusa R, Fujimoto H, Akamata H, Motoori K, Yamamoto S, Ueda T, Ito H. Diffusion-weighted imaging of prostate cancer. J Comput Assist Tomogr. 2005;29:149–53.PubMedCrossRef
11.
Nasu K, Kuroki Y, Tsukamoto T, Nakajima H, Mori K, Minami M. Diffusion-weighted imaging of surgically resected hepatocellular carcinoma: imaging characteristics and relationship among signal intensity, apparent diffusion coefficient, and histopathologic grade. AJR. 2009;193:438–44.PubMedCrossRef
12.
Nasu K, Kuroki Y, Kuroki S, Murakami K, Nawano S, Moriyama N. Diffusion-weighted single shot echo planar imaging of colorectal cancer using a sensitivity-encoding technique. Jpn J Clin Oncol. 2004;34:620–6.PubMedCrossRef
13.
Kim SH, Lee JM, Hong SH, Kim GH, Lee JY, Han JK, et al. Locally advanced rectal cancer: added value of diffusion-weighted MR imaging in the evaluation of tumor response to neoadjuvant chemo- and radiation therapy. Radiology. 2009;253:116–25.PubMedCrossRef
14.
Ko EY, Ha HK, Kim AY, Yoon KH, Yoo CS, Kim HC, et al. CT differentiation of mucinous and nonmucinous colorectal carcinoma. AJR. 2007;188:785–91.PubMedCrossRef
15.
Hussain SM, Outwater EK, Siegelman ES. Mucinous versus nonmucinous rectal carcinomas: differentiation with MR imaging. Radiology. 1999;213:79–85.PubMed
16.
Sugahara T, Korogi Y, Kochi M, Ikushima I, Shigematu Y, Hirai T, et al. Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. JMRI. 1999;9:53–60.PubMedCrossRef
17.
Kang H, O’Connell JB, Maggard MA, Sack J, Ko CY. A 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum. 2005;48:1161–8.PubMedCrossRef
18.
Whiteford MH, Whiteford HM, Yee LF, et al. Usefulness of FDG-PET scan in the assessment of suspected metastatic or recurrent adenocarcinoma of the colon and rectum. Dis Colon Rectum. 2000;43:759–67.PubMedCrossRef
19.
Takenaka D, Ohno Y, Matsumoto K, Aoyama N, Onishi Y, Koyama H, et al. Detection of bone metastases in non-small cell lung cancer patients: comparison of whole-body diffusion-weighted imaging (DWI), whole-body MR imaging without and with DWI, whole-body FDG-PET/CT, and bone scintigraphy. JMRI. 2009;30:298–308.PubMedCrossRef
20.
Burdette JH, Elster AD, Ricci PE. Acute cerebral infarction: quantification of spin-density and T2 shine-through phenomena on diffusion-weighted MR images. Radiology. 1999;212:333–9.PubMed
Metadata
Title
Diffusion-weighted imaging findings of mucinous carcinoma arising in the ano-rectal region: comparison of apparent diffusion coefficient with that of tubular adenocarcinoma
Authors
Katsuhiro Nasu
Yoshifumi Kuroki
Manabu Minami
Publication date
01-02-2012
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 2/2012
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-011-0023-x

Other articles of this Issue 2/2012

Japanese Journal of Radiology 2/2012 Go to the issue

Original article

Distribution of estimated glomerular filtration rate (eGFR) values in patients receiving contrast-enhanced magnetic resonance imaging

Case report

Postmortem computed tomography images of a broken piece of a weapon in the skull

Technical note

Category assessment based on 3D volume data acquired by automated breast ultrasonography

Original article

High-resolution computed tomography findings of influenza virus pneumonia: a comparative study between seasonal and novel (H1N1) influenza virus pneumonia

Original article

Radiographic and CT features of radiation-induced organizing pneumonia syndrome after breast-conserving therapy

Original article

Does concrete composition affect photoneutron production inside radiation therapy bunkers?