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International Journal of Computer Assisted Radiology and Surgery

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01-06-2016 | Original Article

Three-dimensional quantitative assessment of ablation margins based on registration of pre- and post-procedural MRI and distance map

Authors: Soichiro Tani, Servet Tatli, Nobuhiko Hata, Xavier Garcia-Rojas, Olutayo I. Olubiyi, Stuart G. Silverman, Junichi Tokuda

Published in: International Journal of Computer Assisted Radiology and Surgery | Issue 6/2016

Abstract

Purpose

Contrast-enhanced MR images are widely used to confirm the adequacy of ablation margin after liver ablation for early prediction of local recurrence. However, quantitative assessment of the ablation margin by comparing pre- and post-procedural images remains challenging. We developed and tested a novel method for three-dimensional quantitative assessment of ablation margin based on non-rigid image registration and 3D distance map.

Methods

Our method was tested with pre- and post-procedural MR images acquired in 21 patients who underwent image-guided percutaneous liver ablation. The two images were co-registered using non-rigid intensity-based registration. After the tumor and ablation volumes were segmented, target volume coverage, percent of tumor coverage, and Dice similarity coefficient were calculated as metrics representing overall adequacy of ablation. In addition, 3D distance map around the tumor was computed and superimposed on the ablation volume to identify the area with insufficient margins. For patients with local recurrences, the follow-up images were registered to the post-procedural image. Three-dimensional minimum distance between the recurrence and the areas with insufficient margins was quantified.

Results

The percent tumor coverage for all nonrecurrent cases was 100 %. Five cases had tumor recurrences, and the 3D distance map revealed insufficient tumor coverage or a 0-mm margin. It also showed that two recurrences were remote to the insufficient margin.

Conclusions

Non-rigid registration and 3D distance map allow us to quantitatively evaluate the adequacy of the ablation margin after percutaneous liver ablation. The method may be useful to predict local recurrences immediately following ablation procedure.

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Title: Three-dimensional quantitative assessment of ablation margins based on registration of pre- and post-procedural MRI and distance map
Authors: Soichiro Tani
Servet Tatli
Nobuhiko Hata
Xavier Garcia-Rojas
Olutayo I. Olubiyi
Stuart G. Silverman
Junichi Tokuda
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Computer Assisted Radiology and Surgery / Issue 6/2016
Print ISSN: 1861-6410
Electronic ISSN: 1861-6429
DOI: https://doi.org/10.1007/s11548-016-1398-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Three-dimensional quantitative assessment of ablation margins based on registration of pre- and post-procedural MRI and distance map

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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