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La radiologia medica
Published in: La radiologia medica 3/2017

01-03-2017 | URO-GENITAL RADIOLOGY

Incremental value of high b value diffusion-weighted magnetic resonance imaging at 3-T for prediction of extracapsular extension in patients with prostate cancer: preliminary experience

Authors: Ayumu Kido, Tsutomu Tamada, Teruki Sone, Naoki Kanomata, Yoshiyuki Miyaji, Akira Yamamoto, Katsuyoshi Ito

Published in: La radiologia medica | Issue 3/2017

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Abstract

Purpose

To investigate whether high b value diffusion-weighted imaging (DWI) contributes to the improvement of diagnostic ability of extracapsular extension (ECE) in prostate cancer (PC).

Materials and methods

Forty-three patients with PC underwent multiparametric MRI including DWI (b values: 0, 2000 s/mm2) at 3-T. Two radiologists assessed the presence of ECE and the diagnostic certainty degree using conventional diagnostic method by consensus. Tumor apparent diffusion coefficient (ADC, ×10−3 mm2/s) was also measured. Independent predictors of ECE were identified among PSA, tumor ADC, Gleason score, and conventional MRI. ECE in patients with low diagnostic certainty by conventional MRI was further reevaluated using ADC cutoff value, and the results were combined with those of patients with high diagnostic certainty by conventional MRI (MRI + ADC method).

Results

Tumor ADC was an independent predictor of ECE, and the ADC cutoff value was 0.72. The sensitivity, specificity, and accuracy of conventional MRI and MRI + ADC method in the diagnosis of ECE were 44, 92, and 72%, and 78, 96, and 88%, respectively. Among MRI findings leading to the judgement of low diagnostic certainty, broad tumor contact was most common (72% of the patients).

Conclusions

The addition of ADC obtained with high b value DWI at 3-T to conventional MRI improved the diagnostic ability of ECE.
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Metadata
Title
Incremental value of high b value diffusion-weighted magnetic resonance imaging at 3-T for prediction of extracapsular extension in patients with prostate cancer: preliminary experience
Authors
Ayumu Kido
Tsutomu Tamada
Teruki Sone
Naoki Kanomata
Yoshiyuki Miyaji
Akira Yamamoto
Katsuyoshi Ito
Publication date
01-03-2017
Publisher
Springer Milan
Published in
La radiologia medica / Issue 3/2017
Print ISSN: 0033-8362
Electronic ISSN: 1826-6983
DOI
https://doi.org/10.1007/s11547-016-0712-8

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