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International Journal of Mental Health and Addiction

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08-03-2022 | Mood Disorders | Original Article

Association Between Psychiatric Symptoms and Craving in Drug Withdrawal

Authors: Mu Wang, Yanyan Chen, Huazhi Li, Xiaoyu Zhang, Yubing Xu, Zeng-Hui Ding, Zuchang Ma, Yining Sun

Published in: International Journal of Mental Health and Addiction | Issue 5/2023

Abstract

There is an association between drug use and psychological disorders. The correlation between drug craving and psychological symptoms has been studied during drug use and acute withdrawal. However, this correlation has not been researched during non-acute withdrawal. This study recruited 175 females who had long-term drug use history and their abstinent time was at least 30 days. Psychiatric symptoms were tested by Symptoms Checklist-90 (SCL-90) and Visual Analog Scale was utilized to present subjects’ craving intensity. The craving intensity was positively associated with SCL-90 total score and its ten subscales, p < 0.01. SCL-90 total score, somatization, obsessive compulsive, interpersonal sensitivity, depression, anxiety, psychotic symptoms, and additional items were negatively linked to abstinent time, p < 0.05. Moreover, with the increasing abstinent time, the correlation between craving severity and SCL-90 and its subscales was weakening. The craving was positively associated with psychiatric symptoms in non-acute withdrawal women. This association might weaken and the severity of some psychiatric symptoms may ameliorate over time. Women who have drug use disorders would benefit from psychiatric treatment to reduce drug craving and to subsequently decrease relapse rate.

Barta, W. D., Kurth, M. E., Stein, M. D., Tennen, H., Kiene, S. M., & Kiene, S. M. (2009). Craving and self-efficacy in the first five weeks of methadone maintenance therapy: A daily process study. Journal of Studies on Alcohol and Drugs, 70(5), 735–740. https://doi.org/10.15288/jsad.2009.70.735.CrossRefPubMed

Chen, L. -Y., Chen, C. -K., Chen, C. -H., Chang, H. -M., Huang, M. -C., & Xu, K. (2020). Association of craving and depressive symptoms in ketamine-dependent patients undergoing withdrawal treatment. The American Journal on Addictions, 29, 43–50. https://doi.org/10.1111/ajad.12978.CrossRefPubMed

Crichton, N. (2001). Information point: Visual analogue scale. Journal of Clinical Nursing, 10, 697–706.

Derogatis, L. R., Rickels, K., & Rock, A. F. (1976). The SCL-90 and the MMPI: A step in the validation of a new self-report scale. The British Journal of Psychiatry, 128(3), 280–289. https://doi.org/10.1192/bjp.128.3.280CrossRefPubMed

Edlund, M. J., Forman-Hoffman, V. L., Winder, C. R., Heller, D. C., Kroutil, L. A., Lipari, R. N., & Colpe, L. J. (2015). Opioid abuse and depression in adolescents: Results from the National Survey on Drug Use and Health. Drug and Alcohol Dependence, 152, 131–138. https://doi.org/10.1016/j.drugalcdep.2015.04.010CrossRefPubMed

Fatseas, M., Serre, F., Alexandre, J. M., Debrabant, R., Auriacombe, M., & Swendsen, J. (2015). Craving and substance use among patients with alcohol, tobacco, cannabis or heroin addiction: A comparison of substance-specific and person-specific cues. Addiction, 110(6), 1035–1042. https://doi.org/10.1111/add.12882CrossRefPubMed

Fatseas, M., Serre, F., Swendsen, J., & Auriacombe, M. (2018). Effects of anxiety and mood disorders on craving and substance use among patients with substance use disorder: an ecological momentary assessment study. Drug and Alcohol Dependence, S0376871618302011–. https://doi.org/10.1016/j.drugalcdep.2018.03.008

Greenfield, B. L., Venner, K. L., Kelly, J. F., Slaymaker, V., & Bryan, A. D. (2012). The impact of depression on abstinence self-efficacy and substance use outcomes among emerging adults in residential treatment. Psychology of Addictive Behaviors, 26(2), 246–254. https://doi.org/10.1037/a0026917CrossRefPubMedPubMedCentral

Goomany, A., & Dickinson, T. (2015). Prison mental health. Journal of Psychiatric and Mental Health Nursing, 22, 413–422. https://doi.org/10.1111/jpm.12231CrossRefPubMed

Gossop, M., Marsden, J., & Stewart, D. (2006). Remission of psychiatric symptoms among drug misusers after drug dependence treatment. The Journal of Nervous and Mental Disease, 194(11), 826–832. https://doi.org/10.1097/01.nmd.0000244483.17443.0eCrossRefPubMed

Hamidovic, A., Childs, E., Conrad, M., King, A., & de Wit, H. (2010). Stress-induced changes in mood and cortisol release predict mood effects of amphetamine. Drug and Alcohol Dependence, 109, 175–180. https://doi.org/10.1016/j.drugalcdep.2009.12.029CrossRefPubMedPubMedCentral

Heshmati, M., & Russo, S. J. (2015). Anhedonia and the brain reward circuitry in depression. Current Behavioral Neuroscience Reports, 2, 146–153.CrossRefPubMedPubMedCentral

Kampman, K. M., Volpicelli, J. R., McGinnis, D. E., Alterman, A. I., Weinrieb, R. M., D’Angelo, L., & Epperson, L. E. (1998). Reliability and validity of the Cocaine Selective Severity Assessment. Addictive Behaviors, 23, 449–461. https://doi.org/10.1016/S0306-4603(98)00011-2CrossRefPubMed

Kelly, T. M., & Daley, D. C. (2013). Integrated Treatment of Substance Use and Psychiatric Disorders. Social Work in Public Health, 28, 388–406. https://doi.org/10.1080/19371918.2013.774673.CrossRefPubMedPubMedCentral

Kessler, R. C., Nelson, C. B., McGonagle, K. A., Edlund, M. J., Frank, R. G., & Leaf, P. J. (1996). The epidemiology of co-occurring addictive and mental disorders: Implications for prevention and service utilization. American Journal of Orthopsychiatry, 66(1), 17–31. https://doi.org/10.1037/h0080151CrossRefPubMed

Killen, J. D., & Fortmann, S. P. (1997). Craving is associated with smoking relapse: Findings from three prospective studies. Experimental and Clinical Psychopharmacology, 5(2), 137–142. https://doi.org/10.1037/1064-1297.5.2.137CrossRefPubMed

Lee, B., London, E. D., Poldrack, R. A., Farahi, J., Nacca, A., Monterosso, J. R., et al. (2009). Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity. Journal of Neuroscience, 29(47), 14734–14740. https://doi.org/10.1523/JNEUROSCI.3765-09.2009CrossRefPubMed

Loeber, S., Croissant, B., Heinz, A., Mann, K., & Flor, H. (2006). Cue exposure in the treatment of alcohol dependence: Effects on drinking outcome, craving and self-efficacy. British Journal of Clinical Psychology, 45, 515–529. https://doi.org/10.1348/014466505X82586CrossRefPubMed

McCann, U. D., Kuwabara, H., Kumar, A., Palermo, M., Abbey, R., Brasic, J., et al. (2008). Persistent cognitive and dopamine transporter deficits in abstinent methamphetamine users. Synapse (new York, n. y.), 62, 91–100. https://doi.org/10.1002/syn.20471CrossRefPubMed

McMillan, D. E., & Gilmore-Thomas, K. (1996). Stability of opioid craving over time as measured by visual analog scales. Drug and Alcohol Dependence, 40(3), 235–239. https://doi.org/10.1016/0376-8716(96)01218-5CrossRefPubMed

Morgan, C. J., Muetzelfeldt, L., & Curran, H. V. (2010). Consequences of chronic ketamine self-administration upon neurocognitive function and psychological wellbeing: A 1-year longitudinal study. Addiction, 105, 121–133.CrossRefPubMed

Morgan, C. J., Rees, H., & Curran, H. V. (2008). Attentional bias to incentive stimuli in frequent ketamine users. Psychological Medicine, 38, 1331–1340. https://doi.org/10.1017/S0033291707002450CrossRefPubMed

Nakama, H., Chang, L., Cloak, C., Jiang, C., Alicata, D., & Haning, W. (2008). Association between psychiatric symptoms and craving in methamphetamine users. American Journal on Addictions, 17(5), 441–446. https://doi.org/10.1080/10550490802268462CrossRefPubMed

Oliveto, A., Poling, J., Mancino, M. J., Williams, D. K., Thostenson, J., Pruzinsky, R., et al. (2012). Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms. Addiction, 107(1), 131–141. https://doi.org/10.1111/j.1360-0443.2011.03552.xCrossRefPubMed

Oslin, D. W., Cary, M., Slaymaker, V., Colleran, C., & Blow, F. C. (2009). Daily ratings measures of alcohol craving during an inpatient stay define subtypes of alcohol addiction that predict subsequent risk for resumption of drinking. Drug and Alcohol Dependence, 103, 131–136. https://doi.org/10.1111/j.1360-0443.2011.03552.xCrossRefPubMed

Paliwal, P., Hyman, S., & Sinha, R. (2008). Craving predicts time to cocaine relapse: Further validation of the Now and Brief versions of the cocaine craving questionnaire. Drug and Alcohol Dependence, 93(3), 252–259. https://doi.org/10.1016/j.drugalcdep.2007.10.002CrossRefPubMed

Preston, K. L., & Epstein, D. H. (2011). Stress in the daily lives of cocaine and heroin users: Relationship to mood, craving, relapse triggers, and cocaine use. Psychopharmacology (berl), 218, 29–37. https://doi.org/10.1007/s00213-011-2183-xCrossRefPubMed

Ramo, D. E., Myers, M. G., & Brown, S. A. (2010). Self-efficacy mediates the relationship between depression and length of abstinence after treatment among youth but not among adults. Substance Use & Misuse, 45(13), 2301–2322. https://doi.org/10.3109/10826081003710304CrossRef

Rodriguez-Cano, R., Paulus, D. J., Zvolensky, M. J., Lopez-Duran, A., Martinez-Vispo, C., & Becona, E. (2018). Depressive symptoms in the trajectory of craving during smoking cessation treatment: A latent growth curve model. American Journal of Drug and Alcohol Abuse, 44(4), 472–479. https://doi.org/10.1080/00952990.2018.1423687CrossRefPubMed

Sayette, M. A. (2016). The role of craving in substance use disorders: Theoretical and methodological issues. Annual Review of Clinical Psychology, 12(1), 407–433. https://doi.org/10.1146/annurev-clinpsy021815-093351CrossRefPubMed

Sinha, R. (2013). The clinical neurobiology of drug craving. Current Opinion in Neurobiology, 23(4), 649–654. https://doi.org/10.1016/j.conb.2013.05.001CrossRefPubMedPubMedCentral

Sullivan, M. (2018). Depression effects on long-term prescription opioid use, abuse, and addiction. The Clinical Journal of Pain, 34(9), 878–884. https://doi.org/10.1097/AJP.0000000000000603CrossRefPubMed

Tang, Y. Y., Posner, M. I., Rothbart, M. K., & Volkow, N. D. (2015). Circuitry of self-control and its role in reducing addiction. Trends in Cognitive Sciences, 19(8), 439–444. https://doi.org/10.1016/j.tics.2015.06.007CrossRefPubMed

Teesson, M., Hall, W., Lynskey, M., & Degenhardt, L. (2000). Alcohol- and drug-use disorders in Australia: Implications of the National Survey of Mental Health and Wellbeing. Australian & New Zealand Journal of Psychiatry., 34(2), 206–213. https://doi.org/10.1080/j.1440-1614.2000.00715.xCrossRef

Tuchman, E. (2010). Women and addiction: The importance of gender issues in substance abuse research. Journal of Addictive Diseases, 29(2), 127–138. https://doi.org/10.1080/10550881003684582CrossRefPubMed

Volkow, N. D., Wang, G. J., Fowler, J. S., Tomasi, D., & Telang, F. (2010). Addiction: Beyond dopamine reward circuitry. Proceedings of the National Academy of Sciences of the United States of America, 108(37), 15037–15042. https://doi.org/10.1073/pnas.1010654108CrossRef

Volkow, N. D., & Morales, M. (2015). The brain on drugs: From reward to addiction. Cell, 162(4), 712–725. https://doi.org/10.1016/j.cell.2015.07.046CrossRefPubMed

Wang, G., Shi, J., Chen, N., Xu, L., Li, J. L., Li, P., et al. (2013). Effects of length of abstinence on decision-making and craving in methamphetamine abusers. PLoS One, 8(7), e68791. https://doi.org/10.1371/journal.pone.0068791CrossRefPubMedPubMedCentral

Weiss, R. D., Griffin, M. L., & Mirin, S. M. (1992). Drug abuse as self-medication for depression: An empirical study. The American Journal of Drug and Alcohol Abuse, 18(2), 121–129. https://doi.org/10.3109/00952999208992825CrossRefPubMed

Wexler, B. E., Gottschalk, C. H., Fulbright, R. K., Prohovenik, I., Lacadie, C., Rounsaville, B. J., & Gore, J. C. (2001). Functional magnetic resonance imaging of cocaine craving. American Journal of Psychiatry, 158, 86–95. https://doi.org/10.1176/appi.ajp.158.1.86CrossRefPubMed

World Health Organization. (2021). Drugs (psychoactive). https://www.who.int/health-topics/drugs-psychoactive#tab=tab_1. [Accessed 12 Jan 2021]

Yen, C. F., Lin, H. C., Wang, P. W., Ko, C. H., Lee, K. H., Hsu, C. Y., Chung, K. S., Wu, H. C., & Cheng, C. P. (2016). Heroin craving and its correlations with clinical outcome indicators in people with heroin dependence receiving methadone maintenance treatment. Comprehensive Psychiatry, 65, 50–56. https://doi.org/10.1016/j.comppsych.2015.10.001CrossRefPubMed

Zorick, T., Nestor, L., Miotto, K., Sugar, C., Hellemann, G., Scanlon, G., Rawson, R., & London, E. D. (2010). Withdrawal symptoms in abstinent methamphetamine-dependent subjects. Addiction, 105(10), 1809–1818. https://doi.org/10.1111/j.1360-0443.2010.03066.xCrossRefPubMedPubMedCentral

Zweben, J. E., Cohen, J. B., Christian, D., Galloway, G. P., Salinardi, M., Parent, D., & Iguchi, M. (2004). Psychiatric symptoms in methamphetamine users. American Journal on Addictions, 13(2), 181–190. https://doi.org/10.1080/10550490490436055CrossRefPubMed

Title: Association Between Psychiatric Symptoms and Craving in Drug Withdrawal
Authors: Mu Wang
Yanyan Chen
Huazhi Li
Xiaoyu Zhang
Yubing Xu
Zeng-Hui Ding
Zuchang Ma
Yining Sun
Publication date: 08-03-2022
Publisher: Springer US
Keywords: Mood Disorders
Affective Disorder
Anxiety
Published in: International Journal of Mental Health and Addiction / Issue 5/2023
Print ISSN: 1557-1874
Electronic ISSN: 1557-1882
DOI: https://doi.org/10.1007/s11469-022-00783-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association Between Psychiatric Symptoms and Craving in Drug Withdrawal

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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