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Forensic Toxicology
Published in: Forensic Toxicology 1/2016

Open Access 01-01-2016 | Review Article

Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review

Authors: Fabien Bévalot, Nathalie Cartiser, Charline Bottinelli, Laurent Fanton, Jérôme Guitton

Published in: Forensic Toxicology | Issue 1/2016

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Abstract

Vitreous humor (VH) is a gelatinous substance contained in the posterior chamber of the eye, playing a mechanical role in the eyeball. It has been the subject of numerous studies in various forensic applications, primarily for the assessment of postmortem interval and for postmortem chemical analysis. Since most of the xenobiotics present in the bloodstream are detected in VH after crossing the selective blood-retinal barrier, VH is an alternative matrix useful for forensic toxicology. VH analysis offers particular advantages over other biological matrices: it is less prone to postmortem redistribution, is easy to collect, has relatively few interfering compounds for the analytical process, and shows sample stability over time after death. The present study is an overview of VH physiology, drug transport and elimination. Collection, storage, analytical techniques and interpretation of results from qualitative and quantitative points of view are dealt with. The distribution of xenobiotics in VH samples is thus discussed and illustrated by a table reporting the concentrations of 106 drugs from more than 300 case reports. For this purpose, a survey was conducted of publications found in the MEDLINE database from 1969 through April 30, 2015.
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Metadata
Title
Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review
Authors
Fabien Bévalot
Nathalie Cartiser
Charline Bottinelli
Laurent Fanton
Jérôme Guitton
Publication date
01-01-2016
Publisher
Springer Japan
Published in
Forensic Toxicology / Issue 1/2016
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI
https://doi.org/10.1007/s11419-015-0294-5

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