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01-07-2013 | Original Article

[1-(Tetrahydropyran-4-ylmethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone: a new synthetic cannabinoid identified on the drug market

Authors: Dariusz Zuba, Bogna Geppert, Karolina Sekuła, Czesław Żaba

Published in: Forensic Toxicology | Issue 2/2013

Abstract

A new synthetic cannabinoid, [1-(tetrahydropyran-4-ylmethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone, was identified in several resinous samples seized by law enforcement officers in Poland. Its identification was based on liquid chromatography–electrospray ionization–quadrupole time-of-flight–mass spectrometry, gas chromatography–electron ionization–mass spectrometry, one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy, and Fourier-transform infrared spectroscopy. The reported substance was first developed by Abbott Laboratories and patented under the name “A-834,735”. It is a potent agonist of both CB₁ and CB₂ receptors. Although A-834,735 shows moderate selectivity to CB₂ receptor, it exhibits a CB₁ affinity similar to that of ∆⁹-tetrahydrocannabinol. The drug has recently become available in online shops. To our knowledge, this is the first report to disclose a synthetic cannabinoid containing a (tetrahydropyran-4-yl)methyl structure in products seized from the drug market.

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Title: [1-(Tetrahydropyran-4-ylmethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone: a new synthetic cannabinoid identified on the drug market
Authors: Dariusz Zuba
Bogna Geppert
Karolina Sekuła
Czesław Żaba
Publication date: 01-07-2013
Publisher: Springer Japan
Published in: Forensic Toxicology / Issue 2/2013
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-013-0191-8

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[1-(Tetrahydropyran-4-ylmethyl)-1H-indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone: a new synthetic cannabinoid identified on the drug market

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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