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15-03-2022 | Nevi | Original Paper

Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.

Authors: Akifumi Nagatomo, Naoki Inoue, Takuya Konno, Yin Xu, Chinatsu Sakamoto, Mayuko Sone, Aya Shibasaka, Osamu Muraoka, Kiyofumi Ninomiya, Masayuki Yoshikawa, Yoshiaki Manse, Toshio Morikawa

Published in: Journal of Natural Medicines | Issue 3/2022

Abstract

The methanol extract from the leaves of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae), popularly known as mate, maté, or yerba maté, inhibits the intracellular triglyceride accumulation in HepG2 cells and suppresses the plasma triglyceride elevation in olive oil-treated mice. Three new triterpene saponins, termed mateosides I (1), II (2), and III (3), were isolated from the extract along with 29 known compounds. The structures of 1–3 were elucidated based on chemical and spectroscopic evidence. Among the isolates, principal saponin constituents, 2 and matesaponins 1 (7) and 2 (9), potently inhibited the triglyceride accumulation in HepG2 cells simultaneously treated with oleic acid and high glucose. In vivo assay of the methanol extract of I. paraguariensis revealed that 7 and 9 showed anti-hyperlipidemic activities in olive oil-treated mice. These results suggested that the saponin constituents of I. paraguariensis could be valuable bioactive marker for the anti-obesogenic activity.

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Title: Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
Authors: Akifumi Nagatomo
Naoki Inoue
Takuya Konno
Yin Xu
Chinatsu Sakamoto
Mayuko Sone
Aya Shibasaka
Osamu Muraoka
Kiyofumi Ninomiya
Masayuki Yoshikawa
Yoshiaki Manse
Toshio Morikawa
Publication date: 15-03-2022
Publisher: Springer Nature Singapore
Keyword: Nevi
Published in: Journal of Natural Medicines / Issue 3/2022
Print ISSN: 1340-3443
Electronic ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-022-01614-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.

Abstract

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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